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Author
Yamamoto, Haruchika Department of General Thoracic Surgery, Okayama University Hospital
Sugimoto, Seiichiro Department of General Thoracic Surgery, Okayama University Hospital ORCID Kaken ID
Kurosaki, Takeshi Department of Organ Transplant Center, Okayama University Hospital Kaken ID
Miyoshi, Kentaroh Department of Organ Transplant Center, Okayama University Hospital Kaken ID
Otani, Shinji Department of General Thoracic Surgery, Okayama University Hospital
Okazaki, Mikio Department of General Thoracic Surgery, Okayama University Hospital
Yamane, Masaomi Department of General Thoracic Surgery, Okayama University Hospital Kaken ID researchmap
Oto, Takahiro Department of Organ Transplant Center, Okayama University Hospital Kaken ID
Toyooka, Shinichi Department of General Thoracic Surgery, Okayama University Hospital ORCID Kaken ID researchmap
Abstract
Because chronic lung allograft dysfunction (CLAD) develops predominantly on one side after bilateral living-donor lobar lung transplantation (LDLLT), lung perfusion scintigraphy (Q-scinti) was expected to show a perfusion shift to the contralateral unaffected lung with the development of CLAD. Our study examined the potential usefulness of Q-scinti in the diagnosis of CLAD after bilateral LDLLT. We conducted a single-center retrospective cohort study of 58 recipients of bilateral LDLLT. The unilateral shift values on Q-scinti were calculated and compared between the CLAD group (N=27) and the non-CLAD group (N=31) from 5 years before to 5 years after the diagnosis of CLAD. The unilateral shift values in Q-scinti were significantly higher in the CLAD group than in the non-CLAD group from 5 years before the diagnosis of CLAD to 5 years after the diagnosis (P<0.05). The unilateral shift values in Q-scinti were significantly correlated with the percent baseline values of the forced expiratory volume in 1 s (P=0.0037), the total lung capacity (P=0.0028), and the forced vital capacity (P=0.00024) at the diagnosis of CLAD. In patients developing unilateral CLAD after bilateral LDLLT, Q-scinti showed a unilateral perfusion shift to the contralateral unaffected lung. Thus, Q-scinti appears to have the potential to predict unilateral CLAD after bilateral LDLLT.
Published Date
2020-06-29
Publication Title
Scientific Reports
Volume
volume10
Issue
issue1
Publisher
Nature
Start Page
10595
ISSN
2045-2322
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
© The Author(s) 2020
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DOI
Web of Science KeyUT
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isVersionOf https://doi.org/10.1038/s41598-020-67433-4
License
http://creat iveco mmons .org/licen ses/by/4.0/
Funder Name
Ministry of Education, Culture, Sports, Science and Technology
助成番号
19K09305