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Title Alternative
Ameliorative effect of propolis on insulin resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats
Author
Fujiwara, Hiroki
Hosoda, Miho
Hino, Hayato
Hirai, Kazuhiro
Okamoto, Kazuaki
金 鑫
高取 真吾
高木 志真
Abstract
Propolis is known to have abundant bioactive constituents and a variety of biological activities. To investigate the effect of Brazilian propolis on insulin resistance, 10-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a non-insulin-dependent type 2 diabetic model, were treated for 4 weeks with propolis (100 and 300 mg/kg, p.o.) or vehicle (control). Propolis treatment significantly decreased the plasma levels of insulin and insulin resistance index (Homeostasis Model Assessment-Insulin Resistance; HOM-IR), without affecting blood glucose levels and tended to lower systolic blood pressure compared with the control. In isolated and perfused mesenteric vascular beds of OLETF rats, propolis treatment resulted in significant reduction of sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and tended to increase calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS compared with in vehicle-treated OLETF rats. However, propolis treatment did not significantly affect the vasoconstrictor and vasodilator response to noradrenaline, CGRP, acetylcholine, and sodium nitroprusside. These results suggest that propolis could be an effective and functional food to prevent development of insulin resistance.
Keywords
propolis
insulin resistance
Otsuka Long-Evans Tokushima Fatty rat
periarterial nerve function
mesenteric vascular bed
Note
コンテンツの著作権は日本薬学会が有します。
Published Date
2010-06-01
Publication Title
藥學雜誌
Publication Title Alternative
Yakugaku zasshi
Volume
volume130
Issue
issue6
Publisher
日本薬学会
Publisher Alternative
The Pharmaceutical Society of Japan
Start Page
833
End Page
840
ISSN
0031-6903
NCID
AN00284903
Content Type
Journal Article
language
日本語
Copyright Holders
日本薬学会
File Version
publisher
Refereed
True
DOI
PubMed ID
Web of Science KeyUT