Author Tomoda, Takeshi | Kato, Hironari| Miyamoto, Kazuya| Matsumi, Akihiro| Ueta, Eijiro| Fujii, Yuuki| Saragai, Yousuke| Yamazaki, Tatsuhiro| Uchida, Daisuke| Matsumoto, Kazuyuki| Horiguchi, Shigeru| Tsutsumi, Koichiro| Okada, Hiroyuki|
Note Correction to: Surgical Endoscopy https://doi.org/10.1007/s00464-020-07385-y </br>This fulltext is available in Feb. 2021.|
Published Date 2020-02-06
Publication Title Surgical Endoscopy
Publisher Springer
ISSN 09302794
NCID AA10750363
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 32030547
DOI 10.1007/s00464-020-07399-6
Web of Science KeyUT 000515963500002
Related Url isVersionOf https://doi.org/10.1007/s00464-020-07399-6
Author Tomoda, Takeshi| Kato, Hironari| Miyamoto, Kazuya| Matsumi, Akihiro| Ueta, Eijiro| Fujii, Yuuki| Saragai, Yousuke| Yamazaki, Tatsuhiro| chida, Daisuke| atsumoto, Kazuyuki| Horiguchi, Shigeru| Tsutsumi, Koichiro| Okada, Hiroyuki|
Keywords Malignant biliary obstruction Double-balloon enteroscope Endoscopic retrograde cholangiopancreatography Surgically altered anatomy
Note This fulltext is aailable in Jan. 2021.|
Published Date 2020-01-16
Publication Title Surgical Endoscopy
ISSN 09302794
NCID AA10750363
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 31950273
DOI 10.1007/s00464-020-07385-y
Web of Science KeyUT 000507705600001
Related Url isVersionOf https://doi.org/10.1007/s00464-020-07385-y
Title Alternative Efficacy of Helicobacter pylori eradication followed by the administration of a proton pump inhibitor (PPI) or PPI plus a prokinetic in H. pylori-positive patients with dyspepsia
Author 三浦 公| Iwamuro, Masaya| Toyokawa, Tatsuya| Takenaka, Ryuta| Inoue, Masafumi| Ito, Mamoru| Okada, Hiroyuki|
Abstract To investigate whether treatment comprised of Helicobacter pylori eradication followed by the administration of a proton pump inhibitor (PPI) alone and a dual treatment with a PPI plus a prokinetic agent helps relieve symptoms, we treated 26 patients with H. pylori infection and dyspepsia with the sequential treatment and assessed their symptoms. Scores for gastroesophageal reflux disease (GERD) and dyspepsia in a modified F-scale were significantly improved after the eradication of H. pylori, and symptoms were completely relieved in 13 patients. The remaining 13 patients received 4-week treatment with the PPI rabeprazole, and their GERD scores significantly improved after the treatment. The symptoms of five patients completely disappeared ; the other eight patients required dual treatment with a PPI plus the prokinetic acotiamide. Early satiety tended to be relieved after the dual treatment, but the improvement was not significant. Thus, in patients with dyspepsia and an H. pylori infection, the H. pylori should be eradicated first. The administration of a PPI is useful in patients with GERD symptoms, and a PPI+ acotiamide may be beneficial for residual symptoms of early satiety.
Keywords 機能性ディスペプシア (functional dyspepsia) ヘリコバクター・ピロリ (Helicobacter pylori) プロトンポンプ阻害剤 (proton pomp inhibitor) 消化管運動機能改善剤 (acotiamide)
Publication Title Journal of Okayama Medical Association
Published Date 2019-12-02
Volume volume131
Issue issue3
Start Page 139
End Page 143
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.131.139
language 日本語
Copyright Holders Copyright (c) 2019 岡山医学会
File Version publisher
DOI 10.4044/joma.131.139
NAID 130007782646
FullText URL fulltext.pdf
Author Uchida, Daisuke| Kato, Hironari| Matsumoto, Kazuyuki| Ishihara, Yuki| Matsumi, Akihiro| Saragai, Yosuke| Takada, Saimon| Yabe, Shuntaro| Muro, Shinichiro| Tomoda, Takeshi| Horiguchi, Shigeru| Okada, Hiroyuki|
Keywords Endoscopic ultrasound Diagnostic screening program Pancreatic diseases Biliary tract diseases
Published Date 2019-12-18
Publication Title BMC Gastroenterology
Volume volume19
Issue issue1
Publisher BMC
Start Page 220
ISSN 1471-230X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2019
File Version publisher
PubMed ID 31852458
DOI 10.1186/s12876-019-1141-7
Web of Science KeyUT 000510482800002
Related Url isVersionOf https://doi.org/10.1186/s12876-019-1141-7
FullText URL fulltext.pdf
Author Yasutomi, Eriko| Hiraoka, Sakiko| Yamamoto, Shumpei| Oka, Shohei| Hirai, Mami| Yamasaki, Yasushi| Inokuchi, Toshihiro| Kinugasa, Hideaki| Takahara, Masahiro| Harada, Keita| Kato, Jun| Okada, Hiroyuki|
Keywords ulcerative colitis salicylates mesalazine sulfasalazine
Published Date 2019-12-02
Publication Title Journal of Clinical Medicine
Volume volume8
Issue issue12
Publisher MDPI
ISSN 2077-0383
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 by the authors.
File Version publisher
PubMed ID 31810227
DOI 10.3390/jcm8122109
Web of Science KeyUT 000506640400082
Related Url isVersionOf https://doi.org/10.3390/jcm8122109
FullText URL SR9_1_11934.pdf
Author Takahara, Masahiro| Takaki, Akinobu| Hiraoka, Sakiko| Adach, Takuya| Shimomura, Yasuyuki| Matsushita, Hiroshi| Nguyen Tien Thi Thuy| Koike, Kazuko| Ikeda, Airi| Takashima, Shiho| Yamasaki, Yasushi| Inokuchi, Toshihiro| Kinugasa, Hideaki| Sugihara, Yusaku| Harada, Keita| Eikawa, Shingo| Morita, Hidetoshi| Udono, Heiichiro| Okada, Hiroyuki|
Published Date 2019-8-15
Publication Title Scientific Reports
Volume volume9
Publisher Nature Publishing Group
Start Page 11934
ISSN 2045-2322
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2019
File Version Publisher
PubMed ID 31417110
DOI 10.1038/s41598-019-48331-w
Web of Science KeyUT 000480680800048
Related Url isVersionOf https://doi.org/10.1038/s41598-019-48331-w
Author Takada, Saimon| Kato, Hironari| Saragai, Yosuke| Muro, Shinichiro| Uchida, Daisuke| Tomoda, Takeshi| Matsumoto, Kazuyuki| Horiguchi, Shigeru| Tanaka, Noriyuki| Okada, Hiroyuki|
Keywords Contrast-enhanced harmonic endoscopic ultrasound (CH-EUS) Pancreatic neuroendocrine neoplasm (PNEN) Time–intensity curve (TIC) analysis
Note This fulltext will be available in Aug 2020|
Published Date 2019-08-03
Publication Title Journal of Medical Ultrasonics
Volume volume46
Issue issue4
Publisher Springer
Start Page 449
End Page 458
ISSN 1346-4523
NCID AA11563281
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 31377939
DOI 10.1007/s10396-019-00967-x
Web of Science KeyUT 000487923000010
Related Url isVersionOf https://doi.org/10.1007/s10396-019-00967-x
FullText URL CRGM_2019_5742672.pdf
Author Iwamuro, Masaya| Urata, Haruo| Hirata, Shoichiro| Ueki, Toru| Hanabata, Tetsuro| Takeda, Sho| Teraoka, Akira| Okada, Hiroyuki|
Published Date 2019-05-23
Publication Title Case Reports in Gastrointestinal Medicine
Publisher HINDAWI
Start Page 5742672
ISSN 20906528
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders Copyright © 2019 Masaya Iwamuro et al.
File Version publisher
PubMed ID 31240139
DOI 10.1155/2019/5742672
Web of Science KeyUT 000470161500001
Related Url isVersionOf https://doi.org/10.1155/2019/5742672
FullText URL ecancermedicalscience2019_933.pdf
Author Iwamuro, Masaya| Tanaka, Takehiro| Nishida, Kenji| Kanzaki, Hiromitsu| Kawano, Seiji| Kawahara, Yoshiro| Yoshino, Tadashi| Okada, Hiroyuki|
Keywords follicular gastritis gastric neoplasms gastrointestinal endoscope mucosa-associated lymphoid tissue lymphoma nodular gastritis
Published Date 2019-06-03
Publication Title ecancermedicalscience
Volume volume13
Publisher CANCER INTELLIGENCE
Start Page 933
ISSN 1754-6605
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © the authors
File Version publisher
PubMed ID 31281430
DOI 10.3332/ecancer.2019.933
Web of Science KeyUT 000472729000001
Related Url isVersionOf https://doi.org/10.3332/ecancer.2019.933
FullText URL GRP_8159072.pdf
Author Iwamuro, Masaya| Aoyama, Yuki| Suzuki, Seiyuu| Kobayashi, Sayo| Toyokawa, Tatsuya| Moritou, Yuki| Hori, Shinichiro| Matsueda, Kazuhiro| Yoshioka, Masao| Tanaka, Takehiro| Okada, Hiroyuki|
Published Date 2019-09-08
Publication Title Gastroenterology Research and Practice
Publisher Hindawi
Start Page 8159072
ISSN 1687-6121
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders Copyright © 2019 Masaya Iwamuro et al.
File Version publisher
PubMed ID 31582972
DOI 10.1155/2019/8159072
Web of Science KeyUT 000487588000001
Related Url isVersionOf https://doi.org/10.1016/bs.aiip.2019.01.001
FullText URL JGastroenterol_54_11_1019.pdf Table.pdf Figure 1.jpg Figure 2.jpg Figure 3A.tif Figure 3B.tif supplemental figure 1.jpg
Author Matsumoto, Kazuyuki| Ohara, Toshiaki| Fujisawa, Masayoshi| Takaki, Akinobu| Takahara, Masahiro| Tanaka, Noriyuki| Kato, Hironari| Horiguchi, Shigeru| Yoshida, Ryuichi| Umeda, Yuzo| Fushimi, Soichiro| Yagi, Takahito| Matsukawa, Akihiro| Okada, Hiroyuki|
Keywords Immunohistochemistry PD-L1 Pancreatic cancer
Note This fulltext will be available in Apr 2020|
Published Date 2019-04-29
Publication Title Journal of Gastroenterology
Volume volume54
Issue issue11
Start Page 1019
End Page 1028
ISSN 09441174
NCID AA10988015
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 31032528
DOI 10.1007/s00535-019-01586-6
Web of Science KeyUT 000492169400008
Related Url isVersionOf https://doi.org/10.1007/s00535-019-01586-6
FullText URL Gastroenterology156_6_1753.pdf fig.pdf
Author Tomoda, Takeshi| Kato, Hironari| Ueki, Toru| Akimoto, Yutaka| Hata, Hidenori| Fujii, Masakuni| Harada, Ryo| Ogawa, Tsuneyoshi| Wato, Masaki| Takatani, Masahiro| Matsubara, Minoru| Kawai, Yoshinari| Okada, Hiroyuki|
Keywords Drug Inflammation Pancreas Smooth-Muscle Relaxant
Published Date 2019-05-31
Publication Title Gastroenterology
Volume volume156
Issue issue6
Publisher W B SAUNDERS CO-ELSEVIER
Start Page 1753
End Page 1760
ISSN 00165085
NCID AA0065394X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 30772342
DOI 10.1053/j.gastro.2019.01.267
Web of Science KeyUT 10.1053/j.gastro.2019.01.267
Related Url isVersionOf https://doi.org/10.1053/j.gastro.2019.01.267
FullText URL CGH17_6_56.pdf fig.pdf
Author Tomoda, Takeshi| Kato, Hironari| Okada, Hiroyuki|
Published Date 2019-05-31
Publication Title Clinical Gastroenterology and Hepatology
Volume volume17
Issue issue6
Publisher Elsevier Science
Start Page e56
End Page e57
ISSN 15423565
NCID AA11845942
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 by the AGA Institute
File Version author
PubMed ID 29857148
DOI 10.1016/j.cgh.2018.05.032
Web of Science KeyUT 000464657100006
Related Url isVersionOf https://doi.org/10.1016/j.cgh.2018.05.032
FullText URL DLD51_1_168.pdf
Author Iwamuro, Masaya| Urata, Haruo| Tanaka, Takehiro| Okada, Hiroyuki|
Published Date 2019-01-31
Publication Title Digestive and Liver Disease
Volume volume51
Issue issue1
Publisher Elsevier
Start Page 168
ISSN 15908658
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2018 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
File Version author
PubMed ID 30145054
DOI 10.1016/j.dld.2018.07.031
Web of Science KeyUT 000454119300026
Related Url isVersionOf https://doi.org/10.1016/j.dld.2018.07.031
JaLCDOI 10.18926/AMO/55314
FullText URL 71_4_357.pdf
Author Tomoda, Takeshi| Kato, Hironari| Mizukawa, Sho| Muro, Shinichiro| Akimoto, Yutaka| Uchida, Daisuke| Matsumoto, Kazuyuki| Yamamoto, Naoki| Horiguchi, Shigeru| Tsutsumi, Koichiro| Okada, Hiroyuki|
Abstract In the article by Tomoda T et al. entitled “A Multicenter, Prospective, Randomized Controlled Trial Evaluating the Efficacy of Rectal Diclofenac and Sublingual Nitroglycerin as a Combined Prophylactic Treatment for Post-ERCP Pancreatitis”, which appeared in the October 2016 issue, Vol. 70, No. 5, pp405-408, the word “nitroglycerin” should be corrected to “nitrate” throughout the manuscript.
Keywords post-ERCP pancreatitis NSAIDs nitrate
Amo Type Corrected and Republished Article
Published Date 2017-08
Publication Title Acta Medica Okayama
Volume volume71
Issue issue4
Publisher Okayama University Medical School
Start Page 357
End Page 362
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28824193
Related Url replaces http://doi.org/10.18926/AMO/54602
Title Alternative Achalasia treated with per-oral endoscopic myotomy (POEM)
Author Sugihara, Yuusaku| Harada, Keita| Kato, Ryo| Yamauchi, Kenji| Takashima, Shiho| Takei, Daisuke| Inokuchia, Toshihiro| Takahara, Masahiro| Kawano, Seiji| Hiraoka, Sakiko| Tanabe, Shunsuke| Noma, Kazuhiro| Shirakawa, Yasuhiro| Manabe, Noriaki| Inoue, Haruhiro| Okada, Hiroyuki|
Abstract Esophageal achalasia is a disorder of the lower esophageal sphincter muscle. Patients present with dysphagia, chest pain, vomiting, and aspiration. Esophageal achalasia had traditionally been treated with esophageal achalasia balloon dilatation and the Heller-Dor method, but in recent years, the use of per-oral endoscopic myotomy (POEM) has increased. Our patient, a 39-yr-old male, began experiencing dysphagia 4 years prior to his referral to our hospital. Based on the results of esophagogastroduodenoscopy, esophageal radiography and high-resolution manometry, we made the diagnosis of esophageal achalasia (Chicago classification type I) . After informed consent from the patient and his family and approval from our hospital's ethics committee were obtained, we performed a POEM. The patient was discharged on the 4th day post-surgery. At the 1-year post-operative examination, no worsening of symptoms and no relapse were observed. POEM is an excellent treatment method for esophageal achalasia from the perspective of therapeutic effect and prevention of invasion. We recommend that it be considered as the first-choice treatment for achalasia. However, accessibility to the procedure itself is limited due to the few adequately trained operators worldwide. POEM should thus be performed by an expert operator at a high-volume center.
Keywords POEM 食道アカラシア (esophageal achalasia)
Publication Title Journal of Okayama Medical Association
Published Date 2017-08-01
Volume volume129
Issue issue2
Start Page 115
End Page 121
ISSN 0030-1558
Related Url https://doi.org/10.4044/joma.129.115
language 日本語
Copyright Holders Copyright (c) 2017 岡山医学会
File Version publisher
DOI 10.4044/joma.129.115
Title Alternative Adenocarcinoma in the jejunum 20 years after surgery for familial adenomatous polyposis
Author Sugihara, Yuusaku| Kawano, Seiji| Harada, Keita| Takashima, Shiho| Takei, Daisuke| Inokuchi, Toshihiro| Takahara, Masahiro| Hiraoka, Sakiko| Mori, Yoshiko| Kishimoto, Hiroyuki| Nagasaka, Takeshi| Okada, Hiroyuki|
Abstract A 58-year-old Japanese man visited a local clinic for the evaluation of a stomachache. He was diagnosed with intestinal obstruction. His medical history included a proctocolectomy at the age of 38 years, due to familial adenomatous polyposis (FAP). He was referred to our institution, where he underwent a computed tomography examination and endoscopy of the small intestine. The pathological diagnosis was adenocarcinoma. No invasive or metastatic lesions were observed. Therefore, partial resection of the ileum with lymphadenectomy and reconstruction of the ileostomy were performed. Pathological examination revealed that the tumor was type 2, pT3 (SS) , pN1, pPM0, pDM0, pRM0, INFb, ly1, v1, pEX0, PN0. Twenty-nine days after the surgery, the patient was diagnosed with lung metastasis and he underwent lung radiofrequency ablation. We suggest that long-term follow-up is necessary for patients after surgery for FAP, because of the risk of malignant disease developing in other organs.
Keywords 家族性大腸腺腫症 (familial adenomatous polyposis) 小腸癌 (jejunal cancer) 小腸内視鏡検査 (small intestine endoscope)
Publication Title Journal of Okayama Medical Association
Published Date 2017-08-01
Volume volume129
Issue issue2
Start Page 111
End Page 114
ISSN 0030-1558
Related Url https://doi.org/10.4044/joma.129.111
language 日本語
Copyright Holders Copyright (c) 2017 岡山医学会
File Version publisher
DOI 10.4044/joma.129.111
JaLCDOI 10.18926/AMO/55207
FullText URL 71_3_241.pdf
Author Iwamuro, Masaya| Tanaka, Shouichi| Moritou, Yuki| Inaba, Tomoki| Higashi, Reiji| Kusumoto, Chiaki| Yunoki, Naoko| Ishikawa, Shin| Okamoto, Yuko| Kawai, Yoshinari| Kitada, Ken-ichi| Takenaka, Ryuta| Toyokawa, Tatsuya| Okada, Hiroyuki|
Abstract  Most gastric bezoars can be treated with endoscopic fragmentation combined with or without cola dissolution, whereas laparotomy or laparoscopic surgery is generally inevitable for small intestinal bezoars because they cause small bowel obstruction. Therefore, early diagnosis and management of gastric bezoars are necessary to prevent bezoar-induced ileus. To investigate the incidence of overlooked gastric bezoars during the initial esophagogastroduodenoscopy, we retrospectively reviewed the cases of 27 patients diagnosed with gastrointestinal bezoars. The bezoars were diagnosed using esophagogastroduodenoscopy (n=25), abdominal ultrasonography (n=1), and barium follow-through examination (n=1). Bezoars were overlooked in 9/25 patients (36.0%) during the initial endoscopy examination because the bezoars were covered with debris in the stomach. Of the 9 patients, 8 had concomitant gastric ulcers, and the other patient had gastric lymphoma. Although a computed tomography (CT) scan was performed before the second-look endoscopy in 8 of the 9 patients, the bezoars were mistaken as food debris on CT findings and were overlooked in these patients. In conclusion, gastric bezoars may not be discovered during the initial esophagogastroduodenoscopy and CT scan. In cases with debris in the stomach, second-look endoscopy is essential to detect bezoars.
Keywords bezoar gastric ulcer foreign bodies phytobezoar
Amo Type Original Article
Published Date 2017-06
Publication Title Acta Medica Okayama
Volume volume71
Issue issue3
Publisher Okayama University Medical School
Start Page 241
End Page 247
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28655944
JaLCDOI 10.18926/AMO/54977
FullText URL 71_2_97.pdf
Author Iwamuro, Masaya| Kondo, Eisei| Tanaka, Takehiro| Hagiya, Hideharu| Kawano, Seiji| Kawahara, Yoshiro| Otsuka, Fumio| Okada, Hiroyuki|
Abstract We retrospectively analyzed the cases of 14 patients (9 women, 5 men, mean age: 51.6 years) with cytomegalovirus (CMV) involvement in the esophagus, stomach, and/or duodenum diagnosed at a single center, to determine their endoscopic features and clinical backgrounds. Thirteen patients (92.9%) had hematologic disease; the other had rheumatoid arthritis. Of the former, 12 patients underwent allogeneic hematopoietic stem cell transplantation, and 9 of these patients had graft-versus-host disease (GVHD) before undergoing esophagogastroduodenoscopy (EGD). All 14 patients had been taking one or more immunosuppressive agents including cyclosporine (n=10), corticosteroids (n=9), mycophenolic acid (n=6), tacrolimus (n=3), and methotrexate (n=1). Tests for CMV antigenemia were positive in 11 patients (78.6%). EGD examinations revealed esophageal (n=3), gastric (n=9), and duodenal involvement (n=6). Macroscopically, esophageal lesions by CMV infection presented as redness (n=1), erosions (n=1), and ulcers (n=1). Gastric lesions manifested as redness (n=7), erosions (n=3), exfoliated mucosa (n=2), and verrucous erosions (n=1). Mucosal appearances in the duodenum varied: redness (n=2), ulcers (n=2), multiple erosions (n=2), single erosion (n=1), edema (n=1). CMV was detected even in the intact duodenal mucosa (n=1). In conclusion, physicians must recall the relevance of CMV infection when any mucosal alterations exist in the upper gastrointestinal tract of immunosuppressed patients.
Keywords cytomegalovirus duodenum esophagogastroduodenoscopy esophagus stomach
Amo Type Original Article
Published Date 2017-04
Publication Title Acta Medica Okayama
Volume volume71
Issue issue2
Publisher Okayama University Medical School
Start Page 97
End Page 104
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28420890
Title Alternative Changes of colonic mucosa caused by long-term use and discontinuation of anthraquinone
FullText URL 129_23.pdf
Author Iwano, Eiji| Iwamuro, Masaya| 岡田 裕之|
Abstract Anthraquinone, an anthracene derivatives, is widely used as a purgative medicine. The long-term use of anthraquinone is known to cause melanosis coli and elevated lesions in the colon. However, the clinical course of patients who take anthraquinone over a long term and those who discontinue the drug has not been fully investigated. Here we investigated 22 patients who had colonic mucosal changes ( i.e., melanosis coli and elevated lesions) who had been taking anthraquinone for at least one year and discontinued it. We classified the elevated lesions into two subtypes:the small-lesion, which included multiple small nodules that were < 2 mm in dia., and the large-lesion, which included a single or multiple nodules of ≥ 2-mm dia. We used colonoscopy to investigate the changes of colonic lesions between before and after the discontinuation of anthraquinone. The results indicated that the nodules of the small-lesion group were lymphoid follicle hyperplasia. In the large-lesion group, adenoma was most frequently observed ( n=118) , followed by hyperplastic polyp ( n=52) and inflammatory changes with edema ( n=22) . Melanosis coli and elevated lesions were decreased or invisible after the discontinuation of anthraquinone. Our findings thus suggest that the long-term use of anthraquinone may cause some type of elevated lesions due to chronic inflammation. It is recommended that the use of anthraquinone be limited to a short term.
Keywords アントラセン誘導体(anthracene derivatives) アントラキノン(anthraquinone) 大腸黒皮症(melanosis coli) 大腸メラノーシス(pseudomelanosis coli) リンパ濾胞過形成(lymphoid follicle hyperplasia)
Publication Title Journal of Okayama Medical Association
Published Date 2017-04-03
Volume volume129
Issue issue1
Start Page 23
End Page 30
ISSN 0030-1558
language 日本語
Copyright Holders Copyright (c) 2017 岡山医学会
File Version publisher
DOI 10.4044/joma.129.23
NAID 130005632078