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ID 57807
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Sugimoto, Seiichiro Department of General Thoracic Surgery, Okayama University Hospital ORCID Kaken ID
Yamamoto, Haruchika Department of General Thoracic Surgery, Okayama University Hospital
Kurosaki, Takeshi Department of Organ Transplant Center, Okayama University Hospital Kaken ID
Otani, Shinji Department of Organ Transplant Center, Okayama University Hospital Kaken ID
Okazaki, Mikio Department of General Thoracic Surgery, Okayama University Hospital
Yamane, Masaomi Department of General Thoracic Surgery, Okayama University Hospital Kaken ID researchmap
Toyooka, Shinichi Department of General Thoracic Surgery, Okayama University Hospital ORCID Kaken ID publons researchmap
Oto, Takahiro Department of Organ Transplant Center, Okayama University Hospital Kaken ID publons
Abstract
PURPOSE:
The differences in chronic lung allograft dysfunction (CLAD) between living-donor lobar lung transplantation (LDLLT) and cadaveric lung transplantation (CLT) remain unclear. We conducted this study to compare the impact of CLAD on the outcomes after LDLLT vs. CLT.
METHODS:
We conducted a retrospective review of the data of 97 recipients of bilateral lung transplantation, including 51 recipients of LDLLT and 46 recipients of CLT.
RESULTS:
The CLAD-free survival and overall survival after LDLLT were similar to those after CLT. CLAD and restrictive allograft syndrome (RAS), but not bronchiolitis obliterans syndrome (BOS), developed significantly later after LDLLT than after CLT (p = 0.015 and p = 0.035). Consequently, patients with CLAD and RAS, but not those with BOS, after LDLLT had a significantly better overall survival than those after CLT (p = 0.037 and p = 0.0006). Furthermore, after the diagnosis of CLAD, the survival of patients with RAS after LDLLT tended to be better than that after CLT (p = 0.083).
CONCLUSION:
CLAD, especially RAS, appears to develop later after LDLLT than after CLT and seems to have a lower impact on the overall survival after LDLLT than that after CLT.
Keywords
Bronchiolitis obliterans syndrome
Chronic lung allograft dysfunction
Living-donor
Lung transplantation
Rejection
Restrictive allograft syndrome
Published Date
2019-02-21
Publication Title
Surgery Today
Volume
volume49
Issue
issue8
Publisher
Springer
Start Page
686
End Page
693
ISSN
0941-1291
NCID
AA10824685
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
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author
PubMed ID
DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.1007/s00595-019-01782-0
License
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
Citation
Sugimoto, S., Yamamoto, H., Kurosaki, T. et al. Impact of chronic lung allograft dysfunction, especially restrictive allograft syndrome, on the survival after living-donor lobar lung transplantation compared with cadaveric lung transplantation in adults: a single-center experience. Surg Today 49, 686–693 (2019) doi:10.1007/s00595-019-01782-0