JaLCDOI 10.18926/AMO/30979
FullText URL fulltext.pdf
Author Imatoh, Takuya| Miyazaki, Motonobu| Momose, Yoshito| Uryu, Yoko| Tanihara, Shinichi| Une, Hiroshi| Doi, Hiroyuki|
Abstract <p>Leptin is a hormone which is predominantly secreted by adipose tissue. Recent studies have shown that leptin increases arterial blood pressure. Although data from available animal studies clearly indicate an association between leptin and hypertension, results of human studies have been less definitive. We conducted a case-control study to examine the association between serum leptin levels and hypertension in 111 hypertensive subjects and 222 male controls, using conditional logistic regression analyses. Mean serum leptin levels were found to be marginally higher in the case subjects than in the control subjects (3.3 ng/ml versus 3.0 ng/ml), however, conditional logistic regression analysis revealed that subjects in the highest quartile had a significantly increased risk of hypertension compared with those in the lowest quartile, even after adjusting for drinking status and diabetes mellitus (adjusted OR, 2.11;95% CI, 1.01-4.39). Our findings suggest that leptin plays an important role in the development of hypertension.</p>
Keywords epidemiological study hyperleptinemia hypertension leptin
Amo Type Original Article
Published Date 2008-06
Publication Title Acta Medica Okayama
Volume volume62
Issue issue3
Publisher Okayama University Medical School
Start Page 169
End Page 174
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 18596833
Web of Science KeyUT 000257130300004
JaLCDOI 10.18926/AMO/30959
FullText URL fulltext.pdf
Author Fukuoka, Etsuko| Hirokawa, Kumi| Kawakami, Norito| Tsuchiya, Masao| Haratani, Takashi| Kobayashi, Fumio| Araki, Shunichi| Doi, Hiroyuki|
Abstract <p>The purpose of the present study was to assess the association between job strain and smoking cessation among Japanese male employees. In 1997, a baseline questionnaire was given to 2,625 (2,113 males and 512 females) employees of an electronics firm in Gifu Prefecture, Japan. The self-administered questionnaire was a set of questions on smoking habits and consisted of items on socio-demographic variables and smoking habits, including the Japanese version of the Job Content Questionnaire (JCQ). The JCQ consists of scales of job control, job demand, supervisory support, coworker support, job insecurity, physical demands, and isometric load. A total of 733 male smokers were then followed for 2 years, with 446 completing a follow-up questionnaire in 1999 (follow-up rate, 61%). Logistic regression analyses were performed to examine associations between job strain and smoking cessation. Among the 446 participants, 38 had quit smoking. After adjusting for age ((odds ratio: OR) = 0.38, 95% (contidence interval: CI) = 0.15-0.94), men with a high level of physical demands at baseline showed a lower smoking cessation rate at follow-up than did those with a low level. However, when adjustments were made for age and other socio-demographic variables, the odds ratio of smoking cessation showed marginal significance (OR = 0.45, 95% CI = 0.16-1.29). There was no significant association between other job strain variables and smoking cessation at the 2-year follow-up. No significant association was found between job strain and change in the number of smoked cigarettes per day. The present study did not support the hypothesis that higher levels of job stressors are associated with a lower rate of smoking cessation among men.</p>
Keywords job strain smoking worksite support physical demands prospective cohort study
Amo Type Original Article
Published Date 2008-04
Publication Title Acta Medica Okayama
Volume volume62
Issue issue2
Publisher Okayama University Medical School
Start Page 83
End Page 91
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 18464883
Web of Science KeyUT 000255297600004
JaLCDOI 10.18926/AMO/30938
FullText URL fulltext.pdf
Author Babazono, Akira| Kitajima, Hiroyuki| Nishimaki, Shigeru| Nakamura, Tomohiko| Shiga, Seigo| Hayakawa, Masahiro| Tanaka, Tahei| Sato, Kazuo| Nakayama, Hideki| Ibara, Satoshi| Une, Hiroshi| Doi, Hiroyuki|
Abstract <p>We evaluated the infection risks in the neonatal intensive care unit (NICU) using data of NICU infection surveillance data. The subjects were 871 NICU babies, consisting of 465 boys and 406 girls, who were cared for between June 2002 and January 2003 in 7 medical institutions that employed NICU infection surveillance. Infections were defined according to the National Nosocomial Infection Surveillance (NNIS) System. Of the 58 babies with nosocomial infections, 15 had methicillin-resistant Staphylococcus aureus (MRSA) infection. Multiple logistic regression analysis demonstrated that the odds ratio for nosocomial infections was significantly related to gender, birth weight and the insertion of a central venous catheter (CVC). When the birth weight group of more than 1, 500g was regarded as the reference, the odds ratio was 2.35 in the birth weight group of 1,000-1,499g and 8.82 in the birth weight group of less than 1,000g. The odds ratio of the CVC () for nosocomial infection was 2.27. However, other devices including artificial ventilation, umbilical artery catheter, umbilical venous catheter, and urinary catheter were not significant risk factors. The incidence of MRSA infection rapidly increased from 0.3% in the birth weight group of more than 1,500g to 2.1% in the birth weight group of 1,000-1,499g, and to 11.1% in the birth weight group of less than 1,000g. When the birth weight group of more than 1,500g was regarded as the reference, multiple logistic regression analysis demonstrated that the odds ratio was 7.25 in the birth weight group of 1,000-1,499g and 42.88 in the birth weight group of less than 1,000g. These odds ratios were significantly higher than that in the reference group. However, the application of devices did not cause any significant differences in the odds ratio for MRSA infection.</p>
Keywords risk factors nosocomial infection neonatal intensive care unit JANIS
Amo Type Original Article
Published Date 2008-08
Publication Title Acta Medica Okayama
Volume volume62
Issue issue4
Publisher Okayama University Medical School
Start Page 261
End Page 268
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 18766209
Web of Science KeyUT 000258680900006
Title Alternative New antimalarial endoperoxides for drug-resistant Plasmodium falciparumn : The current situation
FullText URL 127_231.pdf
Author Kim, Hye-Sook| Katamoto, Akane| Sato, Akira| Wataya, Yusuke| Doi, Hiroyuki|
Keywords 薬剤耐性マラリア ACT療法(artemisinin-based combination therapy) 新薬開発 環状過酸化物 標的分子
Publication Title 岡山医学会雑誌
Published Date 2015-12-01
Volume volume127
Issue issue3
Start Page 231
End Page 235
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.127.231
language 日本語
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.231
NAID 130005116817
FullText URL fulltext.pdf
Author Liu, Yangyang| Mitsuhashi, Toshiharu| Yamakawa, Michiyo| Sasai, Megumi| Tsuda, Toshihide| Doi, Hiroyuki| Hamada, Jun|
Keywords Elderly Disability Body mass index Long-term care insurance Unhealthy behaviors
Published Date 2019-11-29
Publication Title PeerJ
Volume volume7
Publisher PeerJ
Start Page e8146
ISSN 2167-8359
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 Liu et al.
File Version publisher
PubMed ID 31803538
DOI 10.7717/peerj.8146
Web of Science KeyUT 000499696500006
Related Url isVersionOf https://doi.org/10.7717/peerj.8146