このエントリーをはてなブックマークに追加
ID 32891
JaLCDOI
FullText URL
Author
Yuasa, Ichiro
Hirai, Ryuji
Ota, Tetsuya
Murakami, Masakazu
Naito, Minoru
Doihara, Hiroyoshi Kaken ID researchmap
Date, Hiroshi
Shimizu, Nobuyoshi
Abstract

Resection is the only curative treatment for liver metastasis of colorectal cancers. Despite the supreme regenerative potential of the liver, major hepatectomy sometimes leads to liver failure, and the limitation of resectable liver volumes makes advanced tumors inoperable. This study was attempted to promote liver regeneration using hepatocyte growth factor (HGF) gene transfection by venous-administered adenovirus and to improve the survival of rats after massive hepatectomy. The adenovirus that encodes HGF was administered to rats before 85%-hepatectomy. The administration of HGF gene improved the survival of rats after massive hepatectomy, while the administration of control adenovirus deteriorated their survival. Gene transfection of HGF showed up-regulation of serum HGF, stimulation of hepatocellular proliferation and rapid liver regeneration. Moreover, HGF administration reduced apoptosis of hepatocytes. The administration of HGF gene prevented liver dysfunction after major hepatectomy and may be a new assist for surgery.

Keywords
gene therapy
hepatectomy
HGF
adenoviral vector
Amo Type
Original Article
Published Date
2007-04
Publication Title
Acta Medica Okayama
Volume
volume61
Issue
issue2
Publisher
Okayama University Medical School
Start Page
81
End Page
88
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT