Author Tone, Atsuhito| Shikata, Kenichi| Makino, Hirofumi|
Published Date 2007-05-01
Publication Title 岡山医学会雑誌
Volume volume119
Issue issue1
Content Type Journal Article
Author Sasaki, Motofumi| Shikata, Kenichi| Makino, Hirofumi|
Published Date 2008-01-04
Publication Title 岡山医学会雑誌
Volume volume119
Issue issue3
Content Type Journal Article
Author Kataoka, Hitomi| Shikata, Kenichi| Sasaki, Motofumi| Makino, Hirofumi|
Published Date 2008-08-01
Publication Title 岡山医学会雑誌
Volume volume120
Issue issue2
Content Type Journal Article
Author 岡田 震一| 四方 賢一| 槇野 博史|
Published Date 2005-05-20
Publication Title 岡山医学会雑誌
Volume volume117
Issue issue1
Content Type Journal Article
Author Shikata, Kenichi|
Published Date 2011-12-01
Publication Title 岡山医学会雑誌
Volume volume123
Issue issue3
Content Type Journal Article
Author Nagase, Ryo| Kajitani, Nobuo| Shikata, Kenichi| Ogawa, Daisuke| Kodera, Ryo| Okada, Shinichi| Kido, Yuichi| Makino, Hirofumi|
Published Date 2012-10
Publication Title Clinical and Experimental Nephrology
Volume volume16
Issue issue5
Content Type Journal Article
JaLCDOI 10.18926/AMO/52143
FullText URL 68_1_43.pdf
Author Miyatake, Nobuyuki| Shikata, Kenichi| Makino, Hirofumi| Numata, Takeyuki|
Abstract The link between lifestyle modification and changes in both proteinuria and estimated glomerular filtration rates (eGFRs) was evaluated in Japanese subjects with proteinuria who were not taking medications. We used data from 51 men (35.8±10.0 years) and 74 women (38.0±11.0 years) with proteinuria at baseline and a 1-year follow up. eGFR was defined by a new equation developed specifically for Japanese subjects. Subjects were given advice for dietary and lifestyle improvement at the initial appointment. At the 1-year follow up, eGFR was increased in both sexes, but not at significant levels. (men:p=0.7709, women:p=0.2180). Proteinuria was also improved in many subjects. A decrease in proteinuria may be associated with improving eGFR in Japanese.
Keywords proteinuria estimated glomerular filtration rate (eGFR) lifestyle modification
Amo Type Short Communication
Published Date 2014-02
Publication Title Acta Medica Okayama
Volume volume68
Issue issue1
Publisher Okayama University Medical School
Start Page 43
End Page 46
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 24553488
Web of Science KeyUT 000331592800007
JaLCDOI 10.18926/AMO/47261
FullText URL 65_6_363.pdf
Author Miyatake, Nobuyuki| Shikata, Kenichi| Makino, Hirofumi| Numata, Takeyuki|
Abstract The link between changes in a subject's metabolic syndrome components and his estimated glomerular filtration rate (eGFR) was evaluated in healthy Japanese men. We used data from 120 Japanese men (45.5±8.4 years) with a 1-year follow up. eGFR was defined by a new equation developed for Japan. There were no significant differences in eGFR between men with and without metabolic syndrome components at baseline. Subjects were given advice for dietary and lifestyle improvement. At the 1-year follow up, almost all metabolic syndrome components were significantly improved. However, eGFR was significantly decreased. The changes in eGFR were weakly correlated with abdominal circumference (r=-0.232, p=0.0106). A decrease in abdominal circumference may be associated with improving eGFR in Japanese men.
Keywords abdominal circumference estimated glomerular filtration rate (eGFR) metabolic syndrome lifestyle modification
Amo Type Original Article
Published Date 2011-12
Publication Title Acta Medica Okayama
Volume volume65
Issue issue6
Publisher Okayama University Medical School
Start Page 363
End Page 367
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2011 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 22189476
Web of Science KeyUT 000298516900002
JaLCDOI 10.18926/AMO/32856
FullText URL fulltext.pdf
Author Sumiyoshi, Kazuko| Kawata, Chieko| Shikata, Kenichi| Makino, Hirofumi|
Abstract <p>The aim of this study was to clarify the factors influencing the dietary behavior of patients with diabetic nephropathy. One hundred twenty-two patients with type 2 diabetes were recruited from the outpatients of Okayama University Hospital in Okayama, Japan. We performed a cross-sectional study using a questionnaire including 206 items among 18 categories as follows:background factors, coping behavior (coping scale), degree of uncertainty in illness (uncertainty scale), and dietary behavior. The data were analyzed by correlation analysis, t-test, one-way analysis of variance, Pearson correlation analysis, and multiple regression analysis. We found that those patients with microalbuminuria alone tended to recognize more mild about their kidney status than those with macroalbuminuria and chronic renal failure. We also found that common factors influencing the dietary behavior of diabetic patients with and without nephropathy are as follows:1. coping with the problem (beta0.342, p0.01);2. anxiety about prognosis (beta0.344, p0.01);3. sex (beta0.234, p0.05);4. uncertainty regarding treatment (beta0.377, p0.01);5. negative coping (beta0.354, p0.01);and 6. employment status (beta0.367, p0.01). Coping and uncertainty in illness had a significant relation to positive support and lack of support. To maintain appropriate dietary behavior in diabetic patients, medical staff need to determine what the social supports are important for the patient, and also to ensure good communication among healthcare personnel as well as positive support for patients and families.</p>
Keywords diabetic nephropathy dietary behavior coping uncertainty in illness social support
Amo Type Original Article
Published Date 2010-02
Publication Title Acta Medica Okayama
Volume volume64
Issue issue1
Publisher Okayama University Medical School
Start Page 39
End Page 47
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 20200583
Web of Science KeyUT 000274868300006
JaLCDOI 10.18926/AMO/40013
FullText URL fulltext.pdf
Author Miyatake, Nobuyuki| Shikata, Kenichi| Makino, Hirofumi| Numata, Takeyuki|
Abstract We investigated the link between renal function as evaluated by estimated glomerular filtration rate (eGFR) and metabolic syndrome in Japanese. A total of 11,711 Japanese subjects, aged 20-79 years, were recruited in a cross-sectional clinical investigation. From this group, we further investigated the data on 1,576 subjects. eGFR was calculated using serum creatinine (Cr), age and sex. The diagnosis of metabolic syndrome was based on the Japanese criteria. In the first analysis, 288 men (7.8%) and 498 women (6.2%) were diagnosed with reduced eGFR (<60ml/min). eGFR was not correlated with anthropometric, body composition parameters in either sex. In the second analysis, in subjects without medications, 132 men (20.8%) and 15 women (1.6%) were diagnosed with metabolic syndrome. eGFR was lower in men with abdominal obesity and in women with hypertension was than in those without. Among Japanese not taking medications, lower eGFR may be a characteristic of men with abdominal obesity and of women with hypertension.
Keywords metabolic syndrome estimated glomerular filtration rate (eGFR) abdominal circumference
Amo Type Original Article
Published Date 2010-06
Publication Title Acta Medica Okayama
Volume volume64
Issue issue3
Publisher Okayama University Medical School
Start Page 203
End Page 208
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 20596132
Web of Sience KeyUT 000279094300007
JaLCDOI 10.18926/AMO/40510
FullText URL 64_5_339.pdf
Author Miyatake, Nobuyuki| Shikata, Kenichi| Makino, Hirofumi| Numata, Takeyuki|
Abstract The link between changes in a subject's metabolic syndrome components and her estimated glomerular filtration rate (eGFR) was evaluated in healthy Japanese women. We used data for 53 Japanese women (46.0±10.9 years) with a 1-year follow up. eGFR was defined by a new equation developed for Japan. There were no significant relationships between eGFR and clinical parameters at baseline. Subjects were given advice for dietary and lifestyle improvement. At the 1-year follow up, eGFR was significantly increased. In addition, changes in eGFR were weakly correlated with systolic blood pressure(r=-0.306, p=0.0260). A decrease in systolic blood pressure may be associated with improving eGFR in Japanese women.
Keywords systolic blood pressure estimated glomerular filtration rate (eGFR) metabolic syndrome lifestyle modification
Amo Type Short Communication
Published Date 2010-10
Publication Title Acta Medica Okayama
Volume volume64
Issue issue5
Publisher Okayama University Medical School
Start Page 339
End Page 343
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2010 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 20975768
Web of Science KeyUT 000283563300010
JaLCDOI 10.18926/AMO/31126
FullText URL fulltext.pdf
Author Morioka, Shigeru| Makino, Hirofumi| Shikata, Kenichi| Ota, Zensuke|
Abstract <p>To investigate the role of vitronectin in the progression of diabetic nephropathy, plasma concentrations of vitronectin were measured by enzyme-linked immunosorbent assay in patients with diabetes mellitus and compared with normal control subjects. In diabetic patients with normoalbuminuria and microalbuminuria, plasma concentrations of vitronectin were significantly higher than those of control subjects. Plasma concentrations of vitronectin in diabetic patients with chronic renal failure were significantly lower than those with normal renal function. There was a significant positive correlation between plasma concentration of vitronectin and blood platelet counts. In the early stage of diabetic nephropathy, vitronectin may be increased caused by synthesis from activated platelets. With progression of diabetic nephropathy, plasma vitronectin may be decreased because of accumulation in sclerotic glomeruli and arteriosclerotic lesions. In conclusion, the plasma concentration of vitronectin appears to be an important marker for the progression of diabetic nephropathy.</p>
Keywords vitronectin(S-protein) diabetic nephropathy hypertension chronic renal failure enzyme-linked immunosorbent assay (ELISA)
Amo Type Article
Published Date 1994-06
Publication Title Acta Medica Okayama
Volume volume48
Issue issue3
Publisher Okayama University Medical School
Start Page 137
End Page 142
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 7524268
Web of Science KeyUT A1994NV04300004
JaLCDOI 10.18926/AMO/31556
FullText URL fulltext.pdf
Author Ota, Kosuke| Ota, Zensuke| Shikata, Kenichi| Makino, Hirofumi|
Abstract <p>In order to clarify the mechanism of proteinuria in diabetic nephropathy, ultrastructural changes of the glomerular basement membrane (GBM) in patients with diabetic nephropathy were examined by electron microscopy using our newly devised &#34;tissue negative staining method&#34;. The normal human GBM showed a fine meshwork structure consisting of fibrils forming the small pores. The diameter of these pores was slightly smaller than that of human albumin molecules. The GBM in patients with diabetic nephropathy showed irregular thickening. At higher magnification, hitherto unknown cavities and tunnel structures, which were not seen in normal controls, were observed in the thickened GBM. In some portions, these cavities presented a honeycomb-like appearance. The diameters of the cavities and tunnels were far larger than the dimensions of albumin molecules. These enlarged structures are believed to allow serum protein molecules to pass through the GBM from the capillary lumen to the urinary space. These results suggest that the cause of massive proteinuria in diabetic nephropathy is the disruption of the size barrier of the GBM.</p>
Keywords glomerular basement membrane diabetic nephropathy tissue negative staining nephrotic syndrome ultrastructure
Amo Type Article
Published Date 1993-08
Publication Title Acta Medica Okayama
Volume volume47
Issue issue4
Publisher Okayama University Medical School
Start Page 267
End Page 272
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 7692703
Web of Science KeyUT A1993LV73800008
JaLCDOI 10.18926/AMO/32632
FullText URL fulltext.pdf
Author Ota, Zensuke| Shikata, Kenichi| Ota, Kosuke|
Abstract <p>We developed a &#34;tissue negative staining method&#34; to observe the molecular-level ultrastructure in situ in any portion of the ultrathin sections routinely prepared for electron microscopy. This method was used in electron microscopy of the glomerular basement membranes (GBM). The GBM in patients with nephrotic syndrome was discovered to possess a tunnel structure, designated as &#34;nephrotic tunnel&#34;, with lumen large enough to allow free passage of protein molecules. This tunnel seemed to be involved in the etiology of nephrotic syndrome. This new method appears to be applicable to a variety of purposes in biological studies.</p>
Keywords mechanism proteinuria nephrotic syndrome electron microscopy negative staining
Amo Type Article
Published Date 1992-12
Publication Title Acta Medica Okayama
Volume volume46
Issue issue6
Publisher Okayama University Medical School
Start Page 483
End Page 487
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1485544
Web of Science KeyUT A1992KE49600012
JaLCDOI 10.18926/AMO/30431
FullText URL fulltext.pdf
Author Yamasaki, Yasushi| Makino, Hirofumi| Hironaka, Kazue| Hayashi, Yoshikazu| Shikata, Kenichi| Ota, Zensuke|
Abstract <p>We demonstrated the ultrastructure of rat glomerular basement membrane (GBM) by ultra-high resolution scanning electron microscopy. GBM prepared by sonication methods and conductive-staining could be observed without metal coating at magnifications as high as 400,000 times. The GBM showed an irregular meshwork structure composed of various strands and pores. The width of the strands ranged from 6 to 15 nm, and the diameter of pores ranged from 6 to 50 nm. The present study confirmed our molecular sieve theory of the basement membrane.</p>
Keywords glomerular basement membrance ultrastructure ultra-high resolution scanning electron microscopy conductive staining
Amo Type Article
Published Date 1990-12
Publication Title Acta Medica Okayama
Volume volume44
Issue issue6
Publisher Okayama University Medical School
Start Page 333
End Page 335
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 2075832
Web of Science KeyUT A1990EP70700009
JaLCDOI 10.18926/AMO/30866
FullText URL fulltext.pdf
Author Ota, Zensuke| Kumagai, Isao| Shikata, Kenichi| Makino, Hirofumi|
Abstract <p>Sprague-Dawley rats, 6 with aminonucleoside nephrosis and 6 controls, were intravenously injected with human liver ferritin isolated from post mortem liver, and their 24-h urine samples were examined for human ferritin by immunoradiometric assay. In rats with aminonucleoside nephrosis, the amount of excreted ferritin in urine was forty times greater than in control rats. Much more monomeric ferritin was excreted than that of polymeric ferritin. We are the first to have utilized human liver ferritin as a tracer to measure a minor amount of ferritin by a commercially available kit. Our present study seems to indicate a critical role for glomerular basement membrane as a size barrier.</p>
Keywords glomerular permeabillity size barrier human liver ferritin immunoradiometricassay
Amo Type Article
Published Date 1989-12
Publication Title Acta Medica Okayama
Volume volume43
Issue issue6
Publisher Okayama University Medical School
Start Page 363
End Page 365
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 2624144
Web of Sience KeyUT A1989CG27400008
JaLCDOI 10.18926/54461
Title Alternative Mid-West Japan Clinical Study Consortium
FullText URL 128_121.pdf
Author Shikata, Kenichi|
Keywords 中央西日本臨床研究コンソーシアム 岡山大学病院 ARO 臨床研究 治験
Publication Title Journal of Okayama Medical Association
Published Date 2016-08-01
Volume volume128
Issue issue2
Start Page 121
End Page 123
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.128.121
language 日本語
Copyright Holders Copyright (c) 2016 岡山医学会
File Version publisher
DOI 10.4044/joma.128.121
NAID 130005262529
Author 肥田 和之| 和田 淳| 江口 潤| Zhang Hong| 馬場 雅子| 清田 綾| 橋本 泉| 岡田 達夫| 安原 章浩| 中司 敦子| 赤木 滋| 四方 賢一| 宝来 真志| 二見 淳一郎| 渡辺 英二郎| 松木 泰| 平松 隆司| 槇野 博史| Yashpal S. Kanwar|
Published Date 2007-01-04
Publication Title 岡山医学会雑誌
Volume volume118
Issue issue3
Content Type Journal Article
JaLCDOI 10.18926/AMO/45272
FullText URL 65_2_129.pdf
Author Toyota, Noriko| Ogawa, Daisuke| Ishii, Keita| Hirata, Kyoji| Wada, Jun| Shikata, Kenichi| Makino, Hirofumi|
Abstract A 62-year-old woman with a history of poorly controlled type 2 diabetes mellitus was admitted to our hospital with a 3-week history of mild fever, vomiting, and anorexia. Abdominal computed tomography (CT) showed bilateral hydronephrosis and gas accumulation in the urinary bladder wall and left ureter. Laboratory tests showed leukocytosis and elevated C-reactive protein level. Urine culture showed heavy growth of Escherichia coli. The final diagnosis was emphysematous cystitis. The patient was treated with systemic antibiotics and drainage using a urethral catheter. The clinical and radiographic findings resolved rapidly, and she was discharged from the hospital on day 28. Emphysematous cystitis is a relatively rare urinary tract infection associated with gas formation, and has the potential for a serious outcome if untreated. Early detection by imaging studies such as CT is important in providing prompt treatment and favorable clinical outcome.
Keywords computed tomography diabetes mellitus emphysematous cystitis
Amo Type Case Report
Published Date 2011-04
Publication Title Acta Medica Okayama
Volume volume65
Issue issue2
Publisher Okayama University Medical School
Start Page 129
End Page 133
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2011 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 21519371
Web of Science KeyUT 000289818800009