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ID 31126
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Author
Morioka, Shigeru
Makino, Hirofumi
Ota, Zensuke
Abstract

To investigate the role of vitronectin in the progression of diabetic nephropathy, plasma concentrations of vitronectin were measured by enzyme-linked immunosorbent assay in patients with diabetes mellitus and compared with normal control subjects. In diabetic patients with normoalbuminuria and microalbuminuria, plasma concentrations of vitronectin were significantly higher than those of control subjects. Plasma concentrations of vitronectin in diabetic patients with chronic renal failure were significantly lower than those with normal renal function. There was a significant positive correlation between plasma concentration of vitronectin and blood platelet counts. In the early stage of diabetic nephropathy, vitronectin may be increased caused by synthesis from activated platelets. With progression of diabetic nephropathy, plasma vitronectin may be decreased because of accumulation in sclerotic glomeruli and arteriosclerotic lesions. In conclusion, the plasma concentration of vitronectin appears to be an important marker for the progression of diabetic nephropathy.

Keywords
vitronectin(S-protein)
diabetic nephropathy
hypertension
chronic renal failure
enzyme-linked immunosorbent assay (ELISA)
Amo Type
Article
Published Date
1994-06
Publication Title
Acta Medica Okayama
Volume
volume48
Issue
issue3
Publisher
Okayama University Medical School
Start Page
137
End Page
142
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT