このエントリーをはてなブックマークに追加
ID 31574
JaLCDOI
FullText URL
Author
Imajo, Kenji
Tada, Shinya
Tsubota, Teruhiko
Kimura, Ikuro
Abstract
The activity of pulmonary lymphocytes was evaluated by the detection of interleukin-2 (IL-2) receptor alpha mRNA expression in lung cancer patients associated with diffuse interstitial shadow on roentgenograms of their lungs. Reverse transcription coupled with the polymerase chain reaction was used to detect mRNA expression. In 5 of 6 patients, IL-2R alpha mRNA expression was increased in pulmonary lymphocytes compared with 4 normal controls. The expression in this mRNA in peripheral blood lymphocytes was almost undetectable in either normal controls or these patients. These results suggest that pulmonary lymphocytes in patients with lung cancer associated with diffuse interstitial shadows are activated and may promote the inflammatory process generating pulmonary fibrosis.
Keywords
pulmonary fibrosis
lung cancer
pulmonary lymphocytes
IL-2R α mRNA
RT-PCR
Amo Type
Article
Published Date
1993-04
Publication Title
Acta Medica Okayama
Volume
volume47
Issue
issue2
Publisher
Okayama University Medical School
Start Page
73
End Page
78
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
Copyright© 1999 Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/5957