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ID 52858
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Author
Iwatani, Kayoko
Miyata-Takata, Tomoko
Iwaki, Noriko
Cui, Wei
Sawada-Kitamura, Seiko
Sonobe, Hiroshi
Tamura, Maiko
Saito, Katsuhiko
Miyatani, Katsuya
Yamasaki, Rie
Yamadori, Ichiro
Terasaki, Yasushi
Nakamura, Naoya
Abstract
Cases of low-grade B-cell lymphoma presenting primarily in the bone marrow are rare, and its clinicopathology remains unclear. We retrospectively examined patients with low-grade B-cell lymphoma presenting primarily in the bone marrow. Fourteen patients met the inclusion criteria, including 5 with lymphoplasmacytic lymphoma (LPL), 3 with chronic lymphocytic leukemia/small lymphocytic lymphoma, 2 with follicular lymphoma (FL), and 4 with low-grade B-cell lymphoma not otherwise specified (LGBCL-NOS). The median age was 69.5 years (range, 42-89 years), and a slight male predominance was noted (9 men and 5 women, 1.8: 1). Immunohistochemically, all cases were positive for CD20. One case was positive for CD138. Both cases of FL were positive for CD10 and B-cell lymphoma 2 (BCL-2), and immunoglobulin heavy locus (IgH)/B-cell lymphoma 2 rearrangement was observed by fluorescence in situ hybridization. The myeloid differentiation primary response gene (88) leucine to proline mutation was observed in 3 of 5 LPL, 1 of 2 FL, and 2 of 4 LGBCL-NOS patients. Paraproteinemia was observed in 10 patients; IgM and IgG paraproteinemia were observed in 6 and 3 patients, respectively. In this patient series, 3 patients had died at a median follow-up of 36.5 months; the cause of death of 1 LPL patient was malignant lymphoma itself. Thus, low-grade B-cell lymphoma presenting primarily in the bone marrow has various subtypes, and approximately one-third of the patients had LGBCL-NOS. The immunophenotypic features and myeloid differentiation primary response gene (88) leucine to proline mutation data of LGBCL-NOS suggested that some cases present with characteristics similar to those of LPL or marginal zone lymphoma.
Keywords
Low-grade B cell lymphoma
Bone marrow
LGBCL-NOS
MYD88
Published Date
2014-07
Publication Title
Human Pathology
Volume
volume45
Issue
issue7
Start Page
1379
End Page
1387
ISSN
0046-8177
Content Type
Journal Article
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/52829
language
英語
Copyright Holders
(C) 2014 Elsevier Inc. All rights reserved.
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Refereed
True
DOI
Web of Sience KeyUT