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ID 32031
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Author
Aoki, Sogawa Chiharu
Miyazaki, Ikuko Kaken ID researchmap
Nakanishi, Tohru
Furuta, Hiroaki
Ogawa, Noriko
Abstract

The metallothionein (MT) family is a class of low molecular, intracellular, and cysteine-rich proteins with a high affinity for metals. Although the first of these proteins was discovered nearly 40 years ago, their functional significance remains obscure. Four major isoforms (MT-I, MT-II, MT-III, and MT-IV) have been identified in mammals. MT-I and MT-II are ubiquitously expressed in various organs including the brain, while expression of MT-III and MT-IV is restricted in specific organs. MT-III was detected predominantly in the brain, and characterized as a central nervous system-specific isomer. The role of MTs in the central nervous system has become an intense focus of scientific research. An isomer of MTs, MT-III, of particular interest, was originally discovered as a growth inhibitory factor, and has been found to be markedly reduced in the brain of patients with Alzheimer's disease and several other neurodegenerative diseases. MT-III fulfills unique biological roles in homeostasis of the central nervous system and in the etiology of neuropathological disorders.

Keywords
neuroprotectin
metal transport
localization
gene expression
neurodegenerative disease
Amo Type
Review
Published Date
2001-02
Publication Title
Acta Medica Okayama
Volume
volume55
Issue
issue1
Publisher
Okayama University Medical School
Start Page
1
End Page
9
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT