JaLCDOI 10.18926/AMO/32031
FullText URL fulltext.pdf
Author Aoki, Sogawa Chiharu| Asanuma, Masato| Sogawa, Norio| Miyazaki, Ikuko| Nakanishi, Tohru| Furuta, Hiroaki| Ogawa, Noriko|
Abstract <p>The metallothionein (MT) family is a class of low molecular, intracellular, and cysteine-rich proteins with a high affinity for metals. Although the first of these proteins was discovered nearly 40 years ago, their functional significance remains obscure. Four major isoforms (MT-I, MT-II, MT-III, and MT-IV) have been identified in mammals. MT-I and MT-II are ubiquitously expressed in various organs including the brain, while expression of MT-III and MT-IV is restricted in specific organs. MT-III was detected predominantly in the brain, and characterized as a central nervous system-specific isomer. The role of MTs in the central nervous system has become an intense focus of scientific research. An isomer of MTs, MT-III, of particular interest, was originally discovered as a growth inhibitory factor, and has been found to be markedly reduced in the brain of patients with Alzheimer's disease and several other neurodegenerative diseases. MT-III fulfills unique biological roles in homeostasis of the central nervous system and in the etiology of neuropathological disorders.</p>
Keywords neuroprotectin metal transport localization gene expression neurodegenerative disease
Amo Type Review
Published Date 2001-02
Publication Title Acta Medica Okayama
Volume volume55
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 9
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 11246971
Web of Science KeyUT 000167249900001
Author 十川 紀夫|
Published Date 1991-03-28
Publication Title
Content Type Thesis or Dissertation