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ID 53635
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Author
Sato, Takamaro
Matsunaga, Kazuyuki
Kudo, Chieko
Maeda, Hiroshi
Abstract
[Purpose] We recently reported frequent detection of antibiotic-resistant bacteria on the oral mucosa during the period of hematopoietic cell transplantation (HCT) and suggested an association between oral mucositis and antibiotic-resistant bacterial infection. Methicillin-resistant Staphylococcus spp. were frequently detected, and the oral cavity may be a reservoir of the gene mediating methicillin resistance, mecA. Here, we examined the frequency of mecA carriers in patients undergoing HCT. [Methods] Fifty-nine patients (male (M) = 37, female (F) = 22, 47.3 ± 11.0 years) receiving HCT were enrolled in this study. Buccal swab samples were obtained four times from day −7 to day +20 (once/week), and mecA was detected by PCR. Fifty-two subjects without systemic disease, who completed dental treatment, especially periodontal treatment (M = 21, F = 31, 55.4 ± 14.2 years), were also enrolled as controls and checked for mecA on the oral mucosa. [Results] Seventy-six percent (45/59) of the HCT patients carried mecA at least once in the study period (days −7 to +20), while no control subjects had mecA. The frequency of mecA carriers was 19.2 % from days −7 to −1, while it was significantly increased on days +7 to +13 and +14 to +20, with frequencies of 60.9 and 63.2 %, respectively (P < 0.01, ANOVA). [Conclusions] mecA was detected in oral mucosa of patients undergoing HCT. The high detection frequency of staphylococci resistant to penicillin and beta-lactams in our recent report was supported.
Keywords
Hematopoietic cell transplantation
Oral mucosa
Bacteria
mecA
Antibiotic-resistant
Note
The final publication is available at Springer via http://dx.doi.org/10.1007/s00520-014-2151-1
Published Date
2014-06
Publication Title
Supportive Care in Cancer
Volume
volume22
Issue
issue6
Publisher
Springer Berlin Heidelberg
Start Page
1679
End Page
1683
ISSN
0941-4355
NCID
AA10996793
Content Type
Journal Article
Official Url
http://link.springer.com/journal/520
language
英語
Copyright Holders
Springer-Verlag Berlin Heidelberg
File Version
author
Refereed
True
DOI
PubMed ID
Web of Sience KeyUT