Author Fu, Shanqi| Kuwahara, Miho| Uchida, Yoko| Kondo, Sei| Hayashi, Daichi| Shimomura, Yuji| Takagaki, Asami| Nishida, Takashi| Maruyama, Yusuke| Ikegame, Mika| Hattori, Atsuhiko| Kubota, Satoshi| Hattori, Takako|
Note This fulltext will be available in Mar 2020|
Published Date 2019-03-01
Publication Title Journal of Endocrinology
Volume volume241
Issue issue2
Publisher BIOSCIENTIFICA
Start Page 161
End Page 173
ISSN 0022-0795
NCID AA00697140
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 30889551
DOI 10.1530/JOE-19-0022
Web of Science KeyUT 000468623300006
Related Url isVersionOf https://doi.org/10.1530/JOE-19-0022
FullText URL Mod_Rheumatol_26_6_940.pdf fig.pdf tbl.jpg fig_all.zip
Author Hara, Chikako| Kubota, Satoshi| Nishida, Takashi| Hiasa, Miki| Hattori, Takako| Aoyama, Eriko| Moriyama, Yoshinori| Kamioka, Hiroshi| Takigawa, Masaharu|
Keywords CCN family Cartilage Megakaryocyte Platelet Regeneration
Note This is an Accepted Manuscript of an article published by Taylor & Francis Group| This fulltext availavle in Nov 2017|
Published Date 2016-11
Publication Title Modern Rheumatology
Volume volume26
Issue issue6
Publisher Taylor & Francis
Start Page 940
End Page 949
ISSN 1439-7595
NCID AA1157187X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
PubMed ID 26915735
DOI 10.3109/14397595.2016.1155255
Web of Science KeyUT 000393121500022
Related Url isVersionOf https://doi.org/10.3109/14397595.2016.1155255
Author Hara, Emilio Satoshi| Ono, Mitsuaki| Eguchi, Takanori| Kubota, Satoshi| Hai, Thanh Pham| Sonoyama, Wataru| Tajima, Shoji| Takigawa, Masaharu| Stuart K., Calderwood| Kuboki, Takuo|
Published Date 2013-12-27
Publication Title PLOS ONE
Volume volume8
Issue issue12
Content Type Journal Article
Author Maeda-Uematsu, Aya| Kubota, Satoshi| Kawaki, Harumi| Kawata, Kazumi| Miyake, Yoshiaki| Hattori, Takako| Nishida, Takashi| Moritani, Norifumi| Lyons, Karen M.| Iida, Seiji| Takigawa, Masaharu|
Published Date 2014-05
Publication Title Journal of Cellular Biochemistry
Volume volume115
Issue issue5
Content Type Journal Article
Author Kikuchi, Takeshi| Kubota, Satoshi| Asaumi, Koji| Kawaki, Harumi| Nishida, Takashi| Kawata, Kazumi| Mitani, Shigeru| Tabata, Yasuhiko| Ozaki, Toshifumi| Takigawa, Masaharu|
Published Date 2008-06
Publication Title Tissue Engineering Part A
Volume volume14
Issue issue6
Content Type Journal Article
Author Miyake, Yoshiaki| Furumatsu, Takayuki| Kubota, Satoshi| Kawata, Kazumi| Ozaki, Toshifumi| Takigawa, Masaharu|
Published Date 2011-06-03
Publication Title Biochemical and Biophysical Research Communications
Volume volume409
Issue issue2
Content Type Journal Article
Author Matsumoto, Yohsuke| Motoki, Takahiro| Kubota, Satoshi| Takigawa, Masaharu| Tsubouchi, Hirohito| Gohda, Eiichi|
Published Date 2008-02-01
Publication Title Biochemical and Biophysical Research Communications
Volume volume366
Issue issue1
Content Type Journal Article
Author Moritani, Norifumi H| Kubota, Satoshi| Sugahara, Toshio| Takigawa, Masaharu|
Published Date 2005-04-15
Publication Title Cell Communication and Signaling
Volume volume3
Issue issue1
Content Type Journal Article
Author Asano, Masahiro| Kubota, Satoshi| Nakanishi, Tohru| Nishida, Takashi| Yamaai, Tomoichiro| Yosimichi, Gen| Ohyama, Kazumi| Sugimoto, Tomosada| Murayama, Yoji| Takigawa, Masaharu|
Published Date 2005-10-05
Publication Title Cell Communication and Signaling
Volume volume3
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/30956
FullText URL fulltext.pdf
Author Doi, Hideyuki| Nishida, Keiichiro| Yorimitsu, Masanori| Komiyama, Takamitsu| Kadota, Yasutaka| Tetsunaga, Tomonori| Yoshida, Aki| Kubota, Satoshi| Takigawa, Masaharu| Ozaki, Toshifumi|
Abstract <p>Mechanical stress plays a key role in the pathogenesis of cartilage destruction seen in osteoarthritis (OA). We investigated the effect of cyclic tensile stress (CTS) on the anabolic and catabolic gene expression of rat cultured normal chondrocytes using the Flexercell strain unit. The effects of interleukin (IL)-4, a chondroprotective cytokine, on the changes in gene expression induced by CTS were also investigated. CTS (7% elongation at 0.5 Hz) for 24 h did not affect the expression of aggrecan and type II collagen, whereas CTS significantly upregulated matrix metalloproteinase (MMP)-13 and cathepsin B mRNA expression by chondrocytes. IL-1beta expression was also signifi cantly upregulated by CTS up to 12 h. The upregulation of MMP-13 was observed at 3 h, which was earlier than that of IL-1beta. Furthermore, pre-treatment with IL-4 (10 ng/ml) suppressed both MMP-13 and cathepsin B induction by mechanical stress, as well as CTS-induced IL-1beta expression. Our results suggest that IL-4 might have a therapeutic value in the treatment of OA by downregulation of mechanical stress-induced MMP-13 and cathepsin B expression by chondrocytes.</p>
Keywords IL-4 MMP cathepsin B mechanical stress aggrecanase
Amo Type Original Article
Published Date 2008-04
Publication Title Acta Medica Okayama
Volume volume62
Issue issue2
Publisher Okayama University Medical School
Start Page 119
End Page 126
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 18464888
Web of Sience KeyUT 000255297600008