FullText URL fulltext.pdf
Author Ogura, Soichiro| Nakamura, Kazufumi| Morita, Hiroshi| Toh, Norihisa| Nakagawa, Koji| Yoshida, Masashi| Watanabe, Atsuyuki| Nishii, Nobuhiro| Miyoshi, Toru| Ito, Hiroshi|
Keywords Electrocardiography Fragmented QRS Hospitalization Hypertrophic cardiomyopathy Ventricular arrhythmia.
Published Date 2020-02-25
Publication Title Circulation Journal
Volume volume84
Issue issue3
Publisher The Japanese Circulation Society
Start Page 487
ISSN 1346-9843
NCID AA11591968
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 THE JAPANESE CIRCULATION SOCIETY
File Version publisher
PubMed ID 32037379
DOI 10.1253/circj.CJ-19-0968
Web of Science KeyUT 000516606400021
Related Url isVersionOf https://doi.org/10.1253/circj.CJ-19-0968
FullText URL fulltext.pdf
Author Nakamura, Kazufumi| Akagi, Satoshi| Ejiri, Kentaro| Yoshida, Masashi| Miyoshi, Toru| Toh, Norihisa| Nakagawa, Koji| Takaya, Yoichi| Matsubara, Hiromi| Ito, Hiroshi|
Keywords pulmonary arterial hypertension prostaglandin I-2 nitric oxide endothelin
Published Date 2019-11-23
Publication Title International Journal of Molecular Sciences
Volume volume20
Issue issue23
Publisher MDPI
Start Page 5885
ISSN 1422-0067
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 by the authors.
File Version publisher
PubMed ID 31771203
DOI 10.3390/ijms20235885
Web of Science KeyUT 000504428300067
Related Url isVersionOf https://doi.org/10.3390/ijms20235885
FullText URL fulltext.pdf
Author Ejiri Kentaro| Akagi, Satoshi| Nakamura, Kazufumi| Amioka, Naofumi| Ichikawa, Keishi| Yagi, Takahito| Ito, Hiroshi|
Keywords Rendu-Osler-Weber syndrome arteriovenous malformation pulmonary haemorrhage
Published Date 2019-12-18
Publication Title Pulmonary Circulation
Volume volume9
Issue issue4
Publisher SAGE Publications Inc
ISSN 2045-8932
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2019.
File Version publisher
PubMed ID 31903186
DOI 10.1177/2045894019896677
Web of Science KeyUT 000503484500001
Related Url isVersionOf https://doi.org/10.1177/2045894019896677
FullText URL HR42_5_752.pdf
Author Nakamura, Kazufumi| Miyoshi, Toru|
Published Date 2019-02-14
Publication Title Hypertension Research
Volume volume42
Issue issue425
Publisher Nature Publishing Group
Start Page 752
End Page 753
ISSN 0916-9636
NCID AA10847079
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 30765877
DOI 10.1038/s41440-019-0225-7
Web of Sience KeyUT 000467043700021
Related Url isVersionOf https://doi.org/10.1038/s41440-019-0225-7
JaLCDOI 10.18926/AMO/54600
FullText URL 70_5_397.pdf
Author Akagi, Satoshi| Nakamura, Kazufumi| Akagi, Teiji| Nakagawa, Koji| Takaya, Yoichi| Sarashina, Toshihiro| Ejiri, Kentaro| Ito, Hiroshi|
Abstract A treatment strategy for patients with pulmonary hypertension (PH) and atrial septal defect (ASD) remains unclear. This study was designed to evaluate the effects of initial repair of ASD followed by treatment with PH-specific drugs in patients with PH and ASD. Eligible patients receive transcatheter ASD closure followed by treatment with bosentan and sildenafil. Right heart catheterization is performed at baseline and at 12, 24 and 48 weeks. The primary endpoint is change in pulmonary artery pressure and pulmonary vascular resistance from baseline to follow-up. This study should provide valuable information to establish a therapeutic strategy for PH and ASD.
Keywords pulmonary hypertension atrial septal defect repair and treat transcatheter closure
Amo Type Clinical Study Protocols
Published Date 2016-10
Publication Title Acta Medica Okayama
Volume volume70
Issue issue5
Publisher Okayama University Medical School
Start Page 397
End Page 400
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27777434
Web of Science KeyUT 000388098700011
JaLCDOI 10.18926/AMO/53519
FullText URL 69_3_129.pdf
Author Akagi, Satoshi| Nakamura, Kazufumi| Matsubara, Hiromi| Ogawa, Aiko| Sarashina, Toshihiro| Ejiri, Kentaro| Ito, Hiroshi|
Abstract Pulmonary arterial hypertension (PAH) is characterized by elevation of pulmonary artery pressure caused by pulmonary vasoconstriction and vascular remodeling, which leads to right heart failure and death. Epoprostenol (prostaglandin I2) has a potent short-acting vasodilator property, and intravenous continuous epoprostenol is therefore used for treatment of PAH. Here we review evidence for the usefulness of intravenous continuous epoprostenol therapy in patients with PAH. Epoprostenol therapy is effective in idiopathic PAH patients and in patients with PAH associated with connective tissue disease, portal hypertension or congenital heart diseases, but it is not effective in patients with pulmonary veno-occlusive disease or pulmonary capillary hemangiomatosis. High-dose epoprostenol therapy markedly improved hemodynamics in some patients with PAH, possibly due to reverse remodeling of pulmonary arteries. This therapy has several side effects and complications such as headache, hypotension and catheter-related infections. Intravenous continuous epoprostenol is an effective treatment, but there are still some problems to be resolved.
Keywords pulmonary arterial hypertension epoprostenol high-dose complications side effects
Amo Type Review
Published Date 2015-06
Publication Title Acta Medica Okayama
Volume volume69
Issue issue3
Publisher Okayama University Medical School
Start Page 129
End Page 136
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26101188
Web of Science KeyUT 000356903000001
Author Tokioka, Koji| Kusano, Kengo F.| Morita, Hiroshi| Miura, Daiji| Nishii, Nobuhiro| Nagase, Satoshi| Nakamura, Kazufumi| Kohno, Kunihisa| Ito, Hiroshi| Ohe, Tohru|
Published Date 2014-05-27
Publication Title Journal of the American College of Cardiology
Volume volume63
Issue issue20
Content Type Journal Article
Author Dan, Kazuhiro| Miyoshi, Toru| Ueeda, Masayuki| Ohtsuka, Hiroaki| Ugawa, Satoko| Ohnishi, Nobuhiko| Takaishi, Atsushi| Nakamura, Kazufumi| Kusano, Kengo| Ito, Hiroshi|
Published Date 2012-09
Publication Title Circulation Journal
Volume volume76
Issue issue9
Content Type Journal Article
Author Kitagawa, Masashi| Sugiyama, Hitoshi| Morinaga, Hiroshi| Inoue, Tatsuyuki| Takiue, Keiichi| Ogawa, Ayu| Yamanari, Toshio| Kikumoto, Yoko| Uchida, Haruhito Adam| Kitamura, Shinji| Maeshima, Yohei| Nakamura, Kazufumi| Ito, Hiroshi| Makino, Hirofumi|
Published Date 2013-02-19
Publication Title PLoS ONE
Volume volume8
Issue issue2
Content Type Journal Article
Author Wada, Tadashi| Nakahama, Makoto| Toda, Hironobu| Watanabe, Atsuyuki| Hashimoto, Katsushi| Terasaka, Ritsuko| Nakamura, Kazufumi| Yamada, Nobuyuki| Ito, Hiroshi|
Published Date 2013
Publication Title ISRN Cardiology
Volume volume2013
Content Type Journal Article
Author Nosaka, Kazumasa| Nakamura, Kazufumi| Kusano, Kengo| Toh, Norihisa| Tada, Takeshi| Miyoshi, Toru| Doi, Masayuki| Kohno, Kunihisa| Morita, Hiroshi| Ito, Hiroshi|
Published Date 2013-08
Publication Title Congestive Heart Failure
Volume volume19
Issue issue4
Content Type Journal Article
Author Nakamura, Kazufumi| Ito, Hiroshi|
Published Date 2012-04-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue1
Content Type Journal Article
Author 小川 愛子| 中村 一文| 松原 広己| 藤尾 栄起| 池田 哲也| 宮地 克維| 三浦 大志| 三浦 綾| 永瀬 聡| 草野 研吾| 伊達 洋至| 大江 透|
Published Date 2007-01-04
Publication Title 岡山医学会雑誌
Volume volume118
Issue issue3
Content Type Journal Article
Author Kobayashi, Makoto| Nakamura, Kazufumi| Kusano, Kengo Fukushima| Nakamura, Yoichi| Ohta-Ogo, Keiko| Nagase, Satoshi| Sakuragi, Satoru| Ohe, Tohru|
Published Date 2008-06-22
Publication Title International Journal of Cardiology
Volume volume126
Issue issue3
Content Type Journal Article
JaLCDOI 10.18926/AMO/32121
FullText URL fulltext.pdf
Author Hisamatsu, Kenichi| Kusano, Kengo Fukushima| Morita, Hiroshi| Takenaka, Shiho| Nagase, Satoshi| Nakamura, Kazufumi| Emori, Tetsuro| Matsubara, Hiromi| Ohe, Tohru|
Abstract <p>We attempted to determine the usefulness of body surface mapping (BSM) for differentiating patients with Brugada syndrome (BS) from patients with asymptomatic Brugada syndrome (ABS). Electrocardiograms (ECG) and BSM were recorded in 7 patients with BS and 35 patients with ABS. Following the administration of Ic antiarrhythmic drugs, BSM was recorded in 5 patients with BS and 16 patients with ABS. The maximum amplitudes at J0, J20, J40 and J60 were compared between the 2 groups, as were 3-dimensional maps. The maximum amplitudes at J0, J20 and J60 under control conditions were larger in patients with BS than in patients with ABS (P < 0.05). A three-dimensional map of the ST segments under control conditions in patients with BS showed a higher peak of ST elevation in the median precordium compared to that for patients with ABS. Increases in ST elevation at J20, J40 and J60 following drug administration were greater in patients with BS than in patients with ABS (P < 0.05). Evaluation of the change in amplitude of the ST segment at E5 caused by Ic drug administration was also useful for differentiating between the 2 groups. In conclusion, BSM was useful for differentiating patients with BS from those with ABS.</p>
Keywords body surface map Brugada syndrome asymptomatic Brugada syndrome Ic antiarrhythmic drugs
Amo Type Article
Published Date 2004-02
Publication Title Acta Medica Okayama
Volume volume58
Issue issue1
Publisher Okayama University Medical School
Start Page 29
End Page 35
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 15157009
Web of Sience KeyUT 000189271100005
JaLCDOI 10.18926/AMO/31982
FullText URL fulltext.pdf
Author Yumoto, Akihisa| Kusano, Kengo Fukushima| Nakamura, Kazufumi| Hashimoto, Katsushi| Aoki, Motokuni| Morishita, Ryuichi| Kaneda, Yasufumi| Ohe, Tohru|
Abstract <p>It was recently reported that gene therapy using hepatocyte growth factor (HGF) has the potential to preserve cardiac function after myocardial ischemia. We speculated that this HGF gene therapy could also prevent ventricular arrhythmia. To investigate this possibility, we examined the antiarrhythmic effect of HGF gene therapy in rat acute and old myocardial infarction models. Myocardial ischemia was induced by ligation of the left descending coronary artery. Hemagglutinating virus of Japan (HVJ)-coated liposome containing HGF genes were injected directly into the myocardium fourteen days before programmed pacing. Ventricular fibrillation (VF)was induced by programmed pacing. The VF duration was reduced and the VF threshold increased after HGF gene therapy ( p&#60; 0.01). Histological analyses revealed that the number of vessels in the ischemic border zone was greatly increased after HGF gene injection. These findings revealed that HGF gene therapy has an anti-arrhythmic effect after myocardial ischemia.</p>
Keywords ventricular arrhythmia HGF (hepatocyte growth factor) ischemia HVJ (hemagglutinating virus of Japan)
Amo Type Article
Published Date 2005-06
Publication Title Acta Medica Okayama
Volume volume59
Issue issue3
Publisher Okayama University Medical School
Start Page 73
End Page 78
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 16049559
Web of Sience KeyUT 000230039100001
Author 中村 一文| 草野 研吾| 垣下 幹夫| 三浦 綾| 久松 研一| 西井 伸洋| 伴場 主一| 渡邊 敦之| 藤尾 栄起| 宮地 克維| 永瀬 聡| 森田 宏| 斎藤 博則| 江森 哲郎| 浅沼 幹人| 宮崎 正博| 中村 陽一| 松原 広己| 伏見 和郎| 豊國 伸哉| 大江 透|
Published Date 2004-05-31
Publication Title 岡山医学会雑誌
Volume volume116
Issue issue1
Content Type Journal Article
Author 武田 昌也| 大塚 文男| 中村 一文| 稲垣 兼一| 鈴木 二郎| 三浦 大志| 藤尾 栄起| 松原 広己| 伊達 洋至| 大江 透| 槇野 博史|
Published Date 2006-05-01
Publication Title 岡山医学会雑誌
Volume volume118
Issue issue1
Content Type Journal Article
Author Watanabe, Atsuyuki| Kusano Fukushima, Kengo| Morita, Hiroshi| Miura, Daiji| Sumida, Wakako| Hiramatsu, Shigeki| Banba, Kimikazu| Nishii, Nobuhiro| Nagase, Satoshi| Nakamura, Kazufumi| Sakuragi, Satoru| Ohe, Tohru|
Published Date 2008-05-01
Publication Title 岡山医学会雑誌
Volume volume120
Issue issue1
Content Type Journal Article
Author 中村 一文|
Published Date 1998-09-30
Publication Title
Content Type Thesis or Dissertation