JaLCDOI 10.18926/AMO/30733
FullText URL fulltext.pdf
Author Noguchi, Hirofumi| Matsumoto, Shinichi| Matsushita, Masayuki| Kobayashi, Naoya| Tanaka, Koichi| Matsui, Hideki| Tanaka, Noriaki|
Abstract The development by the Edmonton group of a sirolimus-based, steroid-free, low-tacrolimus regimen is a significant breakthrough that allows the rate of insulin independence after islet transplantation to increase from 13% to 80% at 1 year ; however, the rate is reduced to 50% at 3 years, attributed to prolonged tacrolimus exposure. Recently, immunosuppression agents such as cyclosporine, mycophenolate mofetil, and the novel agent FTY 720 have been used instead of tacrolimus. Lymphocytedepleting antibodies such as anti-thymocyte globulin, alemtuzumab, and hOKT3gamma 1 (ala, ala) have been launched, and a costimulatory blockade of anti-CD40 monoclonal antibodies and CTLA4-Ig will be attempted in the near future. Moreover, the potential of a novel immunosuppressing peptide could now be realized using new technology called the protein transduction system. In this review, we show some of the most recent contributions to the advancement of knowledge in this field.
Keywords islet transplantation steroid-free Edmonton protocol protein transduction syst
Amo Type Review
Published Date 2006-04
Publication Title Acta Medica Okayama
Volume volume60
Issue issue2
Publisher Okayama University Medical School
Start Page 71
End Page 76
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 16680182
Web of Science KeyUT 000237001900001
JaLCDOI 10.18926/AMO/30708
FullText URL fulltext.pdf
Author Kuramitsu, Makoto| Matsui, Hideki| Tokuda, Masaaki| Hatase, Osamu|
Abstract <p>Two factors from normal rat liver cytoplasm inhibited the proliferation of cultured L-929 fibroblasts. One was arginase, the other was a small molecular weight inhibitor stable to trypsin and heat treatment. The small molecular weight inhibitor inhibited the protein and DNA synthesis of L-cells. Inhibition of DNA synthesis was thought to be secondary to the inhibition of protein synthesis.</p>
Keywords cell proliferation growth factor inhibiting factor rat liver cytosol L-cells
Amo Type Article
Published Date 1982-02
Publication Title Acta Medica Okayama
Volume volume36
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 10
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 7064729
Web of Science KeyUT A1982NE20000001
JaLCDOI 10.18926/AMO/30465
FullText URL fulltext.pdf
Author Nakamura, Mitsuo| Itano, Toshifumi| Yamaguchi, Fuminori| Mizobuchi, Masayuki| Tokuda, Masaaki| Matsui, Hideki| Etoh, Siji| Hosokawa, Kiyoshi| Ohmoto, Takashi| Hatase, Osamu|
Abstract <p>Peptides and proteins in the extracellular space in the central nervous system were investigated in vivo using an intracerebral microdialysis probe. The molecular cut-off of the hollow fiber which was used for the probe was approximately 100 kDa. We examined recovery rates of several compounds in vitro. The recovery rates of proteins and peptides were between 7-28%, with the exceptions of substance P and insulin-like growth factor I. The recovery rates of monoamines and their metabolites were 22-40%. In in vivo studies, two major proteins with apparent molecular weights of 62 kDa and 12 kDa, and several minor proteins (28 kDa, 43 kDa, 52 kDa and 70 kDa) were detected by SDS-polyacrylamide gel electrophoresis in the dialysate from a probe implanted in the striatum of anesthetized rats. These results suggest that the newly developed, intracerebral microdialysis probe might be useful for investigating the dynamic changes of peptides and proteins in the central nervous system.</p>
Keywords protein peptide microdialysis extracellular space probe
Amo Type Article
Published Date 1990-02
Publication Title Acta Medica Okayama
Volume volume44
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 8
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 2330841
Web of Science KeyUT A1990CT06800001
Author Matsui, Hideki|
Published Date 2009-12-01
Publication Title 岡山医学会雑誌
Volume volume121
Issue issue3
Content Type Journal Article
Title Alternative A CACNB4 mutation showing altered Ca(v)2.1 function in a patient with Dravet syndrome
FullText URL 121_149.pdf
Author Ohmori, Iori| Ouchida, Mamoru| Mimaki, Nobuyoshi| Nishiki, Teiichi| Tomizawa, Kazuhito| Matsui, Hideki|
Keywords てんかん Dravet 症候群 CACNB4遺伝子 SCN1A 遺伝子
Publication Title 岡山医学会雑誌
Published Date 2009-12-01
Volume volume121
Issue issue3
Start Page 149
End Page 156
ISSN 0030-1558
language 日本語
Copyright Holders 岡山医学会
File Version publisher
DOI 10.4044/joma.121.149
NAID 120002308814
Author Kuramitsu, Makoto| Itano, Toshifumi| Matsui, Hideki| Tokuda, Masaaki| Hatase, Osamu| Murakami, Tetsuhide| Nisida, Isamu| Hayashi, Hideo|
Published Date 1979-04-30
Publication Title 岡山医学会雑誌
Volume volume91
Issue issue3-4
Content Type Journal Article
Author Matsui, Hideki|
Published Date 1982-04-30
Publication Title 岡山医学会雑誌
Volume volume94
Issue issue3-4
Content Type Journal Article
Author 野口 洋文| 松下 正之| Kobayashi, Naoya| Susan Bonner-Weir| 松井 秀樹| 田中 紀章| 田中 紘一| 松本 慎一|
Published Date 2005-09-01
Publication Title 岡山医学会雑誌
Volume volume117
Issue issue2
Content Type Journal Article
FullText URL 118_205.pdf
Author 道上 宏之| 富澤 一仁| 魏 范研| 松下 正之| 陸 雲飛| 市川 智継| 田宮 隆| 松井 秀樹| 伊達 勲|
Keywords プロテインセラピー 悪性脳腫瘍 p 53 エンドソーム 蛋白導入ドメイン
Publication Title 岡山医学会雑誌
Published Date 2007-01-04
Volume volume118
Issue issue3
Start Page 205
End Page 208
ISSN 00301558
language 日本語
Copyright Holders Copyright© 岡山医学会
File Version publisher
DOI 10.4044/joma1947.118.3_205
NAID 10018454083
Title Alternative Novel protein transduction method for cerebral arteries using 11R
FullText URL 120_129.pdf
Author Ogawa, Tomoyuki| Ono, Shigeki| Ichikawa, Tomotsugu| Arimitsu, Seiji| Onoda, Keisuke| Tokunaga, Koji| Sugiu, Kenji| Tomizawa, Kazuhito| Matsui, Hideki| Date, Isao|
Keywords cerebral vasospasm 11R protein transduction method
Publication Title 岡山医学会雑誌
Published Date 2008-08-01
Volume volume120
Issue issue2
Start Page 129
End Page 133
ISSN 00301558
language 日本語
Copyright Holders 岡山医学会
File Version publisher
DOI 10.4044/joma.120.129
NAID 120002310545
Author 魏 范研| 長嶋 一昭| 大島 登志男| 佐伯 恭範| 陸 雲飛| 松下 正之| 山田 祐一郎| 御子柴 克彦| 清野 裕| 松井 秀樹| 富澤 一仁|
Published Date 2007-05-01
Publication Title 岡山医学会雑誌
Volume volume119
Issue issue1
Content Type Journal Article
Author 松井 秀樹|
Published Date 1982-03-31
Publication Title
Content Type Thesis or Dissertation