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Hiroi, Kazumasa Department of Anesthesiology and Resuscitology, Okayama University Hospital
Matsusaki, Takashi Department of Anesthesiology and Resuscitology, Okayama University Hospital Kaken ID
Kaku, Ryuji Department of Anesthesiology and Resuscitology, Okayama University Hospital Kaken ID publons
Umeda, Yuzo Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID researchmap
Yagi, Takahito Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID publons researchmap
Morimatsu, Hiroshi Department of Anesthesiology and Resuscitology, Okayama University Hospital ORCID Kaken ID publons researchmap
Abstract
Background and aims: Postoperative hypoalbuminemia, especially following liver transplantation, can lead to adverse multisystem effects and even death. We investigated the relationship between postoperative albumin levels and organ failure (assessed using Sequential Organ Failure Assessment [SOFA] scores).
Methods: Sixty liver transplant recipients admitted to the intensive care unit (ICU) from 2012 to 2015 were retrospectively divided into 2 groups: lower albumin (LA) (n=28) and higher albumin (HA) (n=32), using whether serum albumin level fell below 3.0 g/dL during the first postoperative week as the stratifying factor. The SOFA scores (primary endpoint) and associated complications (ascites amount, rejection, re-intubation, abdominal re-operation, thrombosis), additional treatment (dialysis, pleural effusion drainage), and duration of ICU stay (secondary endpoints) of the 2 groups were compared.
Results: Average serum albumin levels were significantly different between HA and LA groups (3.6 [3.4-3.8] vs 3.1 [2.9-3.3], respectively, P<.05), although the amounts of albumin infused in the 2 groups during the first postoperative week were not different (HA vs LA: 42 [30-71] vs 40 [30-58], respectively, P=.37). Mean daily SOFA scores were not significantly different between the HA and LA groups (8.3 [6.6-9.0] vs 7.2 [6.3-8.6], P=.73), although the HA group had lower mean cardiovascular SOFA sub-scores than the LA group (0.1 [0-0.4] vs 0.4 [0-1.3], P=.032). There were no significant differences between the groups with regard to complication rates and duration of ICU and hospital stays.
Conclusions: Serum albumin level might not influence cumulative organ function, but it decreases the amount of hemodynamic support required in liver transplant recipients.
Published Date
2019-10-31
Publication Title
Transplantation Proceedings
Volume
volume51
Issue
issue8
Publisher
Elsevier
Start Page
2750
End Page
2754
ISSN
00411345
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
© 2019 The Authors. Published by Elsevier Inc.
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Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.1016/j.transproceed.2019.01.199
License
http://creativecommons.org/licenses/by-nc-nd/4.0/
Citation
Hiroi K, Matsusaki T, Kaku R, Umeda Y, Yagi T, Morimatsu H. Postoperative Course of Serum Albumin Levels and Organ Dysfunction After Liver Transplantation. Transplant Proc. 2019;51(8):2750‐2754. doi:10.1016/j.transproceed.2019.01.199
Open Access (Publisher)
OA
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Non-OpenArchive