Author Kamiya, K| Aoyama, Y| Shirafuji, Y| Hamada, T| Morizane, S| Fujii, K| Hisata, K| Iwatsuki, K|
Published Date 2012-08
Publication Title British Journal of Dermatology
Volume volume167
Issue issue2
Content Type Journal Article
JaLCDOI 10.18926/AMO/32089
FullText URL fulltext.pdf
Author Iwatsuki, Keiji| Yamamoto, Takenobu| Tsuji, Kazuhide| Suzuki, Daisuke| Fujii, Kazuyasu| Matsuura, Hironori| Oono, Takashi|
Abstract <p>Epstein-Barr virus (EBV), or human herpesvirus 4 (HHV-4), infects the vast majority of adults worldwide, and establishes both nonproductive (latent) and productive (lytic) infections. Host immune responses directed against both the lytic and latent cycle-associated EBV antigens induce a diversity of clinical symptoms in patients with chronic active EBV infections who usually contain an oligoclonal pool of EBV-infected lymphocyte subsets in their blood. Episomal EBV genes in the latent infection utilize an array of evasion strategies from host immune responses: the minimized expression of EBV antigens targeted by host cytotoxic T lymphocytes (CTLs), the down-regulation of cell adhesion molecule expression, and the release of virokines to inhibit the host CTLs. The oncogenic role of latent EBV infection is not yet fully understood, but latent membrane proteins (LMPs) expressed during the latency cycle have essential biological properties leading to cellular gene expression and immortalization, and EBV-encoded gene products such as viral interleukin-10 (vIL-10) and bcl-2 homologue function to survive the EBV-infected cells. The subsequent oncogenic DNA damage may lead to the development of neoplasms. EBV-associated NK/T cell lymphoproliferative disorders are prevalent in Asia, but quite rare in Western countries. The genetic immunological background, therefore, is closely linked to the development of EBV-associated neoplasms.</p>
Keywords latent infection hydroa vacciniforme mosquito allergy chronic active EB virus infection hemophagocytic syndrome
Amo Type Article
Published Date 2004-08
Publication Title Acta Medica Okayama
Volume volume58
Issue issue4
Publisher Okayama University Medical School
Start Page 169
End Page 180
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 15551754
Web of Science KeyUT 000223559700001
Author Fujii, Kazuyasu|
Published Date 2005-03-25
Publication Title
Content Type Thesis or Dissertation