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Chen, Xinyu Department of Nuclear Medicine, University Hospital of Würzburg
Kudo, Takashi Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Lapa, Constantin Department of Nuclear Medicine, University Hospital of Würzburg
Buck, Andreas Department of Nuclear Medicine, University Hospital of Würzburg
Higuchi, Takahiro Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University ORCID Kaken ID publons researchmap
Abstract
The norepinephrine transporter (NET) is a major target for the evaluation of the cardiac sympathetic nerve system in patients with heart failure and Parkinson's disease. It is also used in the therapeutic applications against certain types of neuroendocrine tumors, as exemplified by the clinically used 123/131I-MIBG as theranostic single-photon emission computed tomography (SPECT) agent. With the development of more advanced positron emission tomography (PET) technology, more radiotracers targeting NET have been reported, with superior temporal and spatial resolutions, along with the possibility of functional and kinetic analysis. More recently, fluorine-18-labelled NET tracers have drawn increasing attentions from researchers, due to their longer radiological half-life relative to carbon-11 (110 min vs. 20 min), reduced dependence on on-site cyclotrons, and flexibility in the design of novel tracer structures. In the heart, certain NET tracers provide integral diagnostic information on sympathetic innervation and the nerve status. In the central nervous system, such radiotracers can reveal NET distribution and density in pathological conditions. Most radiotracers targeting cardiac NET-function for the cardiac application consistent of derivatives of either norepinephrine or MIBG with its benzylguanidine core structure, e.g. 11C-HED and 18F-LMI1195. In contrast, all NET tracers used in central nervous system applications are derived from clinically used antidepressants. Lastly, possible applications of NET as selective tracers over organic cation transporters (OCTs) in the kidneys and other organs controlled by sympathetic nervous system will also be discussed.
Keywords
Norepinephrine transporter
Benzylguanidine
Phenethylguanidine
Antidepressant
Organic cation transporter
Published Date
2020-04-09
Publication Title
Journal of Neural Transmission
Volume
volume127
Issue
issue6
Publisher
Springer
Start Page
851
End Page
873
ISSN
0300-9564
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
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isVersionOf https://doi.org/10.1007/s00702-020-02180-4
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http://creativecommons.org/licenses/by/4.0/