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ID 58756
Author
Isoshima, Daichi Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Yamashiro, Keisuke Okayama University Hospital ORCID Kaken ID publons
Matsunaga, Kazuyuki Okayama University Hospital
Taniguchi, Makoto Oral Microbiome Center, Taniguchi Dental Clinic
Matsubara, Takehiro Okayama University Hospital
Tomida, Shuta Okayama University Hospital Kaken ID researchmap
Ota, Shinzo Department of Neurology, Brain Attack Center Ota Memorial Hospital
Sato, Michiyoshi Department of Neurology, Brain Attack Center Ota Memorial Hospital
Shimoe, Yutaka Department of Neurology, Brain Attack Center Ota Memorial Hospital
Kohriyama, Tatsuo Department of Neurology, Brain Attack Center Ota Memorial Hospital
Arias, Zulema Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Omori, Kazuhiro Okayama University Hospital ORCID Kaken ID publons researchmap
Yamamoto, Tadashi Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Takashiba, Shogo Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences ORCID Kaken ID publons researchmap
Abstract
There is no conclusive evidence regarding a causal relationship between periodontitis and atherosclerosis. In this study, we examined the microbiome in the oral cavity and atheromatous plaques from atherosclerosis patients with or without periodontitis to investigate the role of oral bacteria in the formation of atheromatous plaques. We chose four patients with and without periodontitis, who had undergone carotid endarterectomy. Bacterial samples were extracted from the tongue surface, from periodontal pocket (during the oral examination), and from the atheromatous plaques (APs). We investigated the general and oral conditions from each patient and performed next-generation sequencing (NGS) analysis for all bacterial samples. There were no significant differences between both groups concerning general conditions. However, the microbiome patterns of the gingival pocket showed differences depending on the absence or presence of periodontitis, while those of the tongue surface were relatively similar. The microbiome pattern of the atheromatous plaques was entirely different from that on the tongue surface and gingival pocket, and oral bacteria were seldom detected. However, the microbiome pattern in atheromatous plaques was different in the presence or absence of periodontitis. These results suggested that oral bacteria did not affect the formation of atheromatous plaques directly.
Keywords
Microbiome
Atherosclerosis
Periodontitis
Next-generating sequencing
Oral bacteria
Note
This fulltext is available in May 2021.
Published Date
2020-05-19
Publication Title
Odontology
Publisher
Springer
ISSN
16181247
NCID
AA11580928
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
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author
PubMed ID
DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.1007/s10266-020-00524-w