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Author
Yumoto, Yasuhiro Radioisotope Centre, Okayama University
Yagi, Takahito Department of Gastroenterological Surgery, Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kakenhi
Sato, Shuhei Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Nouso, Kazuhiro Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kobayashi, Yoshiyuki Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Ohmoto, Masaki Department of Saiseikai Imabari Hospital
Yumoto, Eiichiro Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Nagaya, Isao Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Nakatsukasa, Harushige Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Abstract
BACKGROUND:
Assessment of hepatic functional reserve is important in hepatic resection. The aim of this study was to evaluate the role of hepatic asialoglycoprotein receptor (ASGP-R) analysis in the preoperative estimation of remnant liver function in liver surgery.
METHODS:
One hundred and one patients undergoing hepatic resection for liver tumours were studied. Seventeen patients had preoperative percutaneous transhepatic portal vein embolization (PTPE). Function of the hepatic remnant was estimated before surgery using radioactivity in fusion images of both liver single-photon emission computed tomography and computed tomography scans using (99m)Tc-labelled diethylene triamine penta-acetate-galactosyl-human serum albumin.
RESULTS:
All three patients with an ASGP-R concentration below 400 nmol/l and preoperative total amount of receptor in the future remnant liver (R0-remnant) of less than 53.0 nmol per liver died. Two patients with chronic hepatitis and R0-remnant values between 53.0 and 65.0 nmol per liver and a receptor concentration lower than 600 nmol/l developed liver dysfunction. The incidence of liver failure decreased inversely with increasing R0-remnant value.
CONCLUSION:
A combination of receptor concentration and the amount of hepatic receptor in the future liver remnant as detected on fusion images is useful in evaluating the risk of postoperative liver failure.
Keywords
hepatocellular carcinoma
hepatic resection
remnant hepatic function
fusion image of SPECT and X-ray CT
Note
"This is the peer reviewed version of the following article: Preoperative estimation of remnant hepatic function using fusion images obtained by Tc-99m-labelled galactosyl-human serum albumin liver scintigraphy and computed tomography, which has been published in final form at https://doi.org/10.1002/bjs.7025. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."
Published Date
2010-04-22
Publication Title
British Journal of Surgery
Volume
volume97
Issue
issue6
Publisher
Wiley
Start Page
934
End Page
944
ISSN
0007-1323
NCID
AA00575132
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
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isVersionOf https://doi.org/10.1002/bjs.7025