Author 岡山大学温泉研究所|
Published Date 1959-01
Publication Title 岡山大学温泉研究所報告
Volume volume24
Content Type Others
JaLCDOI 10.18926/40256
Title Alternative A Case of Gastric Polip
FullText URL 024_096_103.pdf
Author Matsumoto, Kinshi| Wakutani, Tohaku| Izumi, Tomokuni|
Abstract We examine patients seeking for spa treatment about erythrocyte sedimentation rate, Takata's reaction, blood picture, gastric juice, urinalysis and so on on their admittion and then repeat these tests once weekly to investigate the reaction of bathing in radioactive hot spring. A 65-year-old patient showed achylia gastrica every time in the test, but he complained no gastric symptom. On x-ray examination we found gastric polyp and verified this on operation.
Publication Title 岡山大学温泉研究所報告
Published Date 1959-01
Volume volume24
Start Page 96
End Page 103
ISSN 0369-7142
language 日本語
File Version publisher
NAID 40017532365
JaLCDOI 10.18926/40252
Title Alternative Studies on Paper-analysis in the Field of Balneology. (II) 1. A New Method for the Determination of Cobalt in Blood. 2. Effects of Radioactive Thermal Bathing and Internal Use of Vitriol Water upon Cobalt Levels in Blood.
FullText URL 024_029_053.pdf
Author Ishibashi, Maruo|
Abstract 1. A new method for the determination of cobalt in blood. The author proposed a new method for the determination of cobalt in blood by means of paper-chromatography. The procedure is follows. In a Kjeldahl colben, 5 m!. of blood is taken, and turned into wet ash with 3 ml. of HNO(3), 0.5 ml. of H(2)SO(4) and 1.5 ml. of HClO(4) and the ash aqueus solution is then neutralized with ammonium hydroxid, the neutralization being indicated by the development of color of 0.1% of p-nitrophenol (one drop) added to the solution. After addition of 2 ml. of 40% ammonium citrate, 0.5 ml. of 20% Na(2)S(2)O(3), 3~5 drops of H(2)O(2) and 1 ml. of o-nitrosoresorcine monomethyl ether (hereafter N.R.M.E.), the mixture is left for at least 15 minutes and the aqueus solution is taken in a stoppered test tube (inside diameter: 1.3 cm., hight: 16.5 cm.). The mixture is shaken with 2 ml. of carbon tetrachloride. Carbon tetrachloride is shaken with 5 ml. of 20% Na(2)CO(3) solution. Then the excess of N.R.M.E. is removed and carbon tetrachloride is concentrated on water bath to 0.3~0.5 ml. and all CCl(4) is used for a determination sample. The sample is placed on the paper (Toyo-filter paper No. 50 or 51A) in a thin line at a distance of 3 cm. from the edge, and the spot is developed with a mixture of 20 ml. of CCl(4) and 1 ml. of 90% ethylalcohoI. After development for 30~40 min., an orange-colored linear spot appears at a distance of 9~10 em. from the origin point. Spot intensity is measured at 460 mμ with Natsume's densitometer and quantitative estimation is made comparing with the standard graph. 2. Effects of radioactive thermal spring bathing and internal use of vitriol water upon cobalt levels in blood. As the author's method above-mentioned is able to determine the cobalt level in a small amount of blood, it is very convenient in investigating cobalt metabolism in the field of balneology. The author examined the changes of cobalt levels in blood after radioactive thermal bathing as well as after internal use of acid vitriol water. a. By the author's method cobalt in normal human blood was 0.4~3.6γ/100ml. in man (average: 1.6±0.4γ/100ml.) and 0.2~2.2γ/100ml. in woman (average: 0.7±0.3γ/100ml.). b. The cobalt levels in blood were measured by the author's method before and 5, 30, 60 minutes after the radioactive thermal single bathing, and before and 1, 2, 3, 4 weeks after a series of radioactive thermal baths (Rn-content: 10~30 Mache, 42~3°C., for 10 minutes). The cobalt levels in the blood of healthy subjects showed no significant change after the thermal single bathing, but those of patients with rheumatoid arthritis showed a slight increase on 3rd or 7th day and a fall on 2nd week of a series of radioactive thermal baths and then tended to return to the initial levels during the 3rd and 4th weeks of spa treatment. c. Thirty ml. of Yanahara mineral water (an acid vitriol water, pH: 2.2) was diluted with plain water to 200 ml. (Co(++)content: ca.3γ) and administered to healthy fasting subjects orally. Blood samples were taken from the cubital vein before and 1, 3, 6 hours after the intake of the vitriol water. The cobalt levels in the blood showed an increase of 14% of the initial levels at 1 and 3 hours and a decrease of 22% at 6 hours after the drinking of Yanahara mineral water.
Publication Title 岡山大学温泉研究所報告
Published Date 1959-01
Volume volume24
Start Page 29
End Page 53
ISSN 0369-7142
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/40250
language 日本語
File Version publisher
NAID 40017532366
JaLCDOI 10.18926/40253
Title Alternative Studies on Paper-analysis in the Field of Balneology. (3) The Changes of the Serum Protein Fractions and Lipoprotein Fractions Following the Bathing in Radioactive Hot Spring
FullText URL 024_054_079.pdf
Author Ishibashi, Maruo|
Abstract I. Some fundamental conditions and procedures on filter-paper electrophoresis were investigated. The electrophoretic apparatus of Natsume Seisakusho and Toyo No. 51 filter-paper were used. Electrophoresis was carried out under the current of 0.25 mA/cm. in 300 Volt during 5 hours, using veronal buffer pH 8.6 (μ=0.05). In measuring of serum protein fractions, the adequate volume of the materials loaded is in the range of 0.005~0.01 ml. and in the case of lipoprotein, 0.02 ml. of serum is used. Paper-strip was stained with bromophenol blue or sudan black B, then making it transparent with heat-solved paraffin and photometered by Nataume's densitometer. The reproducibility of the above-mentioned method with a confidence of 99% was as follows: Serum protein fractions Albumin 53.4±1.8% α(1)-Globulin 3.3±0.3 α(2)-Globulin 6.0±0.5 β-Globulin 12.2±0.7 γ-Globulin 25.1±1.1 Serum lipoprotein fractions α 20.6±2.6% β+γ 79.4±2.6 II. Changes in serum protein fractions and lipoprotein fractions following the radioactive hot spring bathing were as follows: 1). In rabbits, the albumin-fraction of serum protein increased after a series of baths in radioactive hot spring, and the β- and γ-globulin-fractions decreased. 2). By cholesterol-feeding, the albumin-fraction of serum protein of rabbits decreased and the β- and γ-globulin-fractions increased significantly but when a series of baths was carried out in cholesterol-fed rabbits the decrease in the albumin-fraction was slighter than the former. 3). α-globulin-fraction of serum lipoprotein increased after single bathing in radioactive hot spring and (β+γ) -globulin-fractions showed an inverse change, but the changes of lipoprotein-fractions following a series of baths were not remarkable. 4). By cholesterol-feeding, the ratio of lipoprotein-fractions (β+γ/α) increased, but the ratio tended to decrease following a series of baths in radioactive hot spring.
Publication Title 岡山大学温泉研究所報告
Published Date 1959-01
Volume volume24
Start Page 54
End Page 79
ISSN 0369-7142
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/40250
language 日本語
File Version publisher
NAID 40017532366
JaLCDOI 10.18926/40251
Title Alternative Clinical and Experimental Studies of Therapeutic Effects of Radioactive Thermal Bath on Peripheric Disorders of Circulation Part 4 Therapeutic Effects of Radioactive Thermal Bath on Blood pressure
FullText URL 024_001_028.pdf
Author Matsumoto, Kinshi|
Abstract 1) The effects of a single bath in the radioactive hot spring on the blood pressure and the pulse rate. The author observed the changes of the blood pressure and the pulse rate of subjects bathing for 20 minutes, 39°± 1°C, in temperature, in the radioactive hot spring in Misasa. It may be summerized as follows (Table 2, Fig. 1). a. In the hypertensive group (maximal blood pressure······181 mm. Hg. and over), the maximal blood pressure had decreased immediately after bathing, and remained at this level even 2 hours after bathing. The minimal blood pressure reacted in the same manner as the maximal blood pressure. b. The moderate hypertensive group (maximal blood pressure······180-161 mm. Hg.). In a few instances, the maximal blood pressure had increased immediately after bathing, but decreased within 30-90 minutes after bathing. Changes in the minimal blood pressure were not so remarkable. c. In the normal group (maximal blood pressure······160~101 mm. Hg.), the maximal blood pressure had lowered within 30-90 minutes after the radioactive hot spring bathing. The minimal blood pressure showed no significant changes. b. The pulse rate had increased immediately after bathing in all groups, but within 30 minntes had returned to the initial rate and there were no further changes for 2 hours (Table 2, Fig. 2). 2) The effects of a radioactive vapour bath on the blood pressure and the pulse rate. After a bathing in vapour bath (10~15 minutes), the maximal and the minimal blood pressure showed mild decrease for 2 hours. The changes of the pulse rate and the pulse amplitude were not so remarkable (Table 3, Fig. 3). 3) The effects of a series of baths in the radioactive spring on the blood pressure. The author observed the changes in the blood pressure of the subjects bathed 2 or 3 times daily in the radioactive hot spring in Misasa, at a temperature of 42~43°C., 5~10 minutes. The blood pressure of subjects was measured once a day (at 7 a.m.) for the first week, and subsequently once weekly for two additional weeks. Subjects with an initial maximal blood pressure over 160 mm. Hg. showed a fall on the second day of the spa treatment followed by a temporary rise on the 3rd or 4th day, after which the pressure fell to the 2nd day level again, and then remained fairly constant to the end of the observation period. Subjects with an initial blood pressure under 159 mm. Hg. also showed a fall in the course of the spa treatment, but the degree of the fall was slighter than that of the former (Table 4, Fig. 4). This tendency was also observed on the out-patients (Table 5, Fig. 5). The changes of the blood pressure and pulse rate of subjects after a bath for 20 minutes, in water 39±1°C. in temperature, on the first day of the spa therapy were compared with those occuring on the 6th or 7th day, and it was observed that the patterns of the changes in blood pressure following bathing on the two days were significantly different (i.e. on the latter, so called "the initial blood pressure increase following the bathing" was not observed) (Table 6,7,8, Fig.6,7,8,9,). 4) The remote investigation on the spa visitors with hypertension and/or arteriosclerosis. The author investigated the course of patients with hypertension and/or arteriosclerosis who received the spa treatment at Misasa after returned to home. The incidence of subjects who answered as being good was 86%, and it was observed the fall of the maximal and the minimal blood pressure, especially the fall was remakable in subjects who stayed at spa about 4 weeks (Table 10, 11, 12, 13, 14, 15, Fig. 10). 5) The incidence of hypertension among the residents in the spa resort and those residing in other places. The author measured the blood presssre of the out-patients of his institute over 41 years of age from June, 1956 to May, 1957. The incidence of patients with the maximal blood pressure over 160 mm. Hg. was 16.4% in spa resort, and 25.7% in places where there are no hot springs. Using x(2)-test, the difference between the two was recognised as being significant (Table 16, 18). 6) Comparison of the mortality rate of patients with hypertension between residents in the spa resort and those residing in other places. The author examined the mortality rate of persons with hypertension in the area under the jurisdiction of the Kurayoshi Sanitary Institute, Tottori prefecture, from 1954 to 1956. The rate of mortality in the spa resort was 17.5% as compared to 21.4% in other places (Table17).
Publication Title 岡山大学温泉研究所報告
Published Date 1959-01
Volume volume24
Start Page 1
End Page 28
ISSN 0369-7142
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/40250
language 日本語
File Version publisher
NAID 40017532368
Author Institute for Thermal Spring Research, Okayama University|
Published Date 1959-01
Publication Title 岡山大学温泉研究所報告
Volume volume24
Content Type Others
JaLCDOI 10.18926/40254
Title Alternative General Survey of the Spa Treatment at Misasa Spa, Tottori Prefecture
FullText URL pitsr_024_080_086.pdf
Author Wakutani, Tohaku| Matsumoto, Kinshi| Yamamoto, Yasuhisa|
Abstract Misasa Hot Spring is one of the most famous radioactiye hot springs in Japan. A general survey of the spa treatment at Misasa Spa was carried out in Feburary, 1957. The informations we have gathered may be summarized as follows: 1). The number of the spa visitors seeking for curative treatment was almost equally divided between men and women and the majority of the spa visitors was over 50 years old. 2). 65% of the spa visitors came to this hot spring with the specific purpose of balneotherapy. 19.3% came for rest, 13.3% for the purpose of after-care. 3). Those who visited Misasa Spa for the first time were 44.7%, the rest being those who visited this spa over 2 times. 18.3% of them had consultation with or were under the direction of a physician. 4). The length of time they stay at this spa for curative treatment: 41.6% of the spa visitors stay for 8~14 days, 17.9% of them 15~20 days and 31% of them over three weeks. 5). About 74% of the spa visitors bathe 3 to 5 times a day for curative treatment, and 82% of them drink hot spring water. 6). Symptoms of bathing reaction such as generalised fatigue, constipation, loss of appetite, joint pain, abdominal pain and so on were observed in 50% of the spa visitors.
Publication Title 岡山大学温泉研究所報告
Published Date 1959-01
Volume volume24
Start Page 80
End Page 86
ISSN 0369-7142
language 日本語
File Version publisher
NAID 120002462890
JaLCDOI 10.18926/40255
Title Alternative A Case of Agammaglobulinemia
FullText URL 024_087_095.pdf
Author Matsumoto, Kinshi| Wakutani, Tohaku|
Abstract A case of agammaglobulinemia, probably of the secondary type, is reported in adult female (45-year-old) with tumor of the mediastinum. The authors described the bibliographical consideration and arose the attention of agammaglobulinemia. Reports on agammaglobulinemia may increase in practise if electrophoresis of the serum protein-fraction is used as a routine examination method.
Publication Title 岡山大学温泉研究所報告
Published Date 1959-01
Volume volume24
Start Page 87
End Page 95
ISSN 0369-7142
language 日本語
File Version publisher
NAID 40017532364