JaLCDOI 10.18926/40322
Title Alternative THE CLINICAL STUDIES OF RHEUMATOID ARTHRITIS (I)
FullText URL 016_035_048.pdf
Author Morinaga, Hiroshi|
Abstract The value of spa treatment of rheumatic disease is an established feature of medical management based on experiences for many centuries. The author has been practising the balneotherapy of rheumatic diseases at Misasa Spa for several years, and has found this therapy efficacious in many cases in relieving the anemia that accompanies rheumatoid arthritis. For this reason, the author is investigating the metabolism of iron in rheumatic anemia, which is expected to occur in the course of the spa treatment. In this report, the results of clinical examinations of 24 patients with rheumatoid arthritis, of the type (2. 2. 2.) Polyarthritis systemica chronica (in Prof. Kodama's classification of arthritis), are described. I. Some observations of anemia in rheumatoid arthritis 1. The peripheral blood The number of erythrocytes is 266×10(4)~455×10(4)/c. mm. (average: (381±32)×10(4)/c. mm.), Hb-content : 55~90% (average : 76±5.8%), and the color index is about 1.0. The anemia of rheumatic disease treated is mostly normochromic. The white blood count is between 3240 and 13300/c. mm. (average: 6421±955/c. mm. ), and the number of the leucocytes in 80% of the cases ranges within the normal limits. Eosinophilia is observed in 15% of the cases. 2. Anemia-producing substance in the serum of rheumatoid arthritis When serum from rheumatoid arthritis patients was injected into rabbits, the number of erythrocytes and the hemoglobin -content of the rabbits was found to decrease markedly for 2~6hours after the injection. But no such effect was observed when the serum of healthy subjects was injected. From this, the author presumes the presence of an anemia-producing substance in the serum of rheumatoid arthritis. The nature of this substance in now under investigation. II. Clinical-biochemical studies 3. Gastric acidity of rheumatic patients Of 7 cases examined, anacidity of gastric juice was observed in 2 cases, subacidity in other 2 cases and normacidity in the remaining 3 cases. Thus, a decrease in the gastric acidity was found to occur in 57% of the cases. 4. Takata-serum-test and sedimentation rate It is said that the sedimentation rate and the Weltmann-reaction are very sensitive indicators of the extent of the activity of rheumatic disease. The Takata-serum-test was applied in 18 cases and was found to give positive results in 10 cases (55%). The sedimentation rate was found to increase in 17 of 20 cases (85%). 5. Blood uric acid As is well known, the concentration of uric acid is abnormally high in the blood of patients with gout; while, according to the literature, the blood uric acid levels of patients with rheumatoid arthritis range within the normal limits. The author, using the method of Benedict, obtained the following results for blood uric acid in 14 normal subjects in fasting state: Range - 2.30~3.47mg./dl. , 5% rejection limit -- 1.97~3.68mg./dl. In 5 of 7 cases of rheumatoid arthritis, the blood uric acid levels were shown to be above the upper limit of the normal range, but the concentrations of blood uric acid of non-rheumatic joint diseases and neuralgias were mostly within the normal range. 6. Blood sugar The fasting blood sugar levels of rheumatoid patients ranged from 82 to 1l0mg./dl. (average : 100mg./dl.), higher than the levels of healthy subjects (78~108mg./dl., average : 90mg./dl.). The intravenously injected glucose load test was applied to 8 rheumatoid patients. A solution of 40 ml. of 20% glucose was injected into a fasting subject for 2 minutes. Blood samples were taken before the injection, 3 minutes after the injection, and at each subsequent 10 minute-interval for 70 minutes. The glucose tolerance curves in 5 of these cases were found to be out of the normal range. It is to be noticed that the average blood sugar for rheumatoid arthritis is similar to the curve for liver disease. 7. Serum alkaline phosphatase activity and serum phosphorus The method of Taussky-Shorr was used for the determination of the level of alkaline phosphatase activity and inorganic phosphate in the serum. The alkaline phosphatase activity of 11 normal individuals ranged from 1.4 to 6.4 Shinowara-Jones-Rheinhart units/dl. (5% rejection limit), while in 4 of 8 cases of rheumatoid arthritis, it was of abnormally high levels. The concentration of inorganic phosphate in the serum of 12 normal subjects ranged from 2.9 to 5.0mg. /dl. (5% rejection limit), while in 3 cases of rheumatoid patients, it showed higher levels than normal. 8. Total cholesterol in serum The total cholesterol in the serum of fasting normal individuals was measured by Bloor's method, and the concentration was found to range from 124 to 188mg./dl. (rejection limit of 5% level of significance), and the total cholesterol in the serum of rheumatoid arthritis to be abnormally high in concentration in 6 of 7 cases. The liver function was evaluated by the Takata-serum-test, the test of fasting blood sugar levels, the glucose load test, and the test of serum alkaline phosphatase activity; and from this the hepatic dysfunction was found to occur in rheumatoid arthritis patients in about 50% of the cases examined. Disturbances in the protein, fat, and carbohydrate metabolism were also found to occur. The above-mentioned findings indicate that rheumatoid arthritis is not only a disease of the joints, but also a general and systemic illness. Attention must accordingly be given to the general condition of the patient in the treatment of rheumatic disease.
Publication Title 岡山大学温泉研究所報告
Published Date 1956-01
Volume volume16
Start Page 35
End Page 48
ISSN 0369-7142
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/40318
language 日本語
File Version publisher
NAID 40017532470
JaLCDOI 10.18926/40321
Title Alternative SEASONAL VARIATION OF GASTRIC ACIDITY
FullText URL pitsr_016_031_034.pdf
Author Morinaga, Hiroshi|
Abstract Since, in Japan situated in the temperate zone, climatic change through the four seasons of a year is regular, it is expected that there the physiological reactions of the human body may vary regularly in accordance with the climatic change. In fact, we experience that the attacks of diseases and their conditions are in close connection with the changes of the seasons. The author investigated the effect of the seasons upon the human gastric acidity, by means of the coffein-test, in 580 cases with gastrointestinal disorders, at the Misasa Branch Hospital of Okayama University, Misasa Spa in Tottori Prefecture, in 1946~1946. Hyperacidity was verified in 194 (33%) of 580 cases, normacidity in 134 (23%), anacidity in 138 (24%) and hypacidity in 114 (20%). The percentage of hyperacidity increases in winter (41%), decreases in spring (32%) and in summer (28%), and increases again in autumn (34%). The cases of anacidity decrease in winter and spring, but increase in summer. In chi-square test, the season and the acidity of gastric juice were taken as factors of variation. The chi-square was computed with the result: Pr {X(3)=14.013<16.919} =5%, so it cannot be asserted that the seasonal changes effect the acidity of gastric juice. But if Comparison is made between summer and winter with respect to the anacidity-hypacidity vs. the hyperacidity, the author: obtains Pr {X(2)=6.06> 5.412} =2%. It is thus verified that the cases of hyperacidity predominate over those of anacidity-hypacidity in winter, while the relation is reverse in summer. As was mentioned above, the tendency is obvious that the acidity of gastric juice decreases in summer and increases in winter. It was found that there is a regular seasonal variation in gastric acidity.
Publication Title 岡山大学温泉研究所報告
Published Date 1956-01
Volume volume16
Start Page 31
End Page 34
ISSN 0369-7142
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/40318
language 日本語
File Version publisher
NAID 120002462901
JaLCDOI 10.18926/40320
Title Alternative ANEMIA-PRODUCING SUBSTANCE IN RHEUMATOID ARTHRITIS
FullText URL pitsr_016_019_030.pdf
Author Kishida, Senzo|
Abstract The anemia that usually accompanies rheumatoid arthritis has been thought to be caused by an infection of unknown etiology. The author found from his experiment that a temporary anemia is caused in rabbits by the injection of the serum of patients with rheumatoid arthritis into them, but no such effect by the injection of the serum of healthy subjects. The author presumes the existance of an anemia-producing substance in the serum of the rheumatoid arthritis. The nature of this substance is now under investigation.
Publication Title 岡山大学温泉研究所報告
Published Date 1956-01
Volume volume16
Start Page 19
End Page 30
ISSN 0369-7142
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/40318
language 日本語
File Version publisher
NAID 120002462900
JaLCDOI 10.18926/40319
Title Alternative REPORT OF THE CHEMICAL ANALYSIS OF MISASA HOT SPRINGS, TOTTORI PREFECTURE
FullText URL 016_001_018.pdf
Author Oshima, Yoshio| Mifune, Masaaki| Yamada, Naoharu| Ueyama, Akiko|
Abstract The water samples of 55 springs of Misasa were analysed in the years 1950~1951. The temperatures of the waters ranged from 44° to 85° C. Radon content ranged from 34.1 to 2360×10(-10) curies per liter. pH 6.2~7.5. Evaporation residue: 534~1940 mg/kg. K(+) :10.4~47.3mg/kg. Na(+) : 140.4~574mg/kg. Ca(2+) : 7.56~49.06mg/kg. Mg(2+) : 0.11~15.3mg/kg.. Fe(2+) : 0.10~0.67mg/kg. Cl(-) : 138~854mg/kg. SO(4)(2-) : 29.2~187mg/kg. HCO(3)(-) : 74.8~370mg/kg. HBO(2)(-) : 1.80~19.6mg/kg. S(2)O(3)(2-) : o.62~3.69mg/kg. Radon sources seem to exist at shallow places under the ground and the radon in the thermal wacer is supposed to have been derive partly from the ground water which also contains considerable amount of radon. A close linear correlation (r=0.751) was proved between the sulfate and the chloride ion contents.
Publication Title 岡山大学温泉研究所報告
Published Date 1956-01
Volume volume16
Start Page 1
End Page 18
ISSN 0369-7142
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/40318
language 日本語
File Version publisher
NAID 40017532473
Author 岡山大学温泉研究所|
Published Date 1956-01
Publication Title 岡山大学温泉研究所報告
Volume volume16
Content Type Others
Author 岡山大学温泉研究所|
Published Date 1956-01
Publication Title 岡山大学温泉研究所報告
Volume volume16
Content Type Others