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ID 52429
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Proton Magnetic Resonance Spectroscopy in Patients with Migration Disorders
Author
Asano, Takashi
Oka, Eiji
Kawahara, Michiko
Sakae, Katsumi
Hiraki, Norio
Ohtahara, Shunsuke
Abstract
Proton Magnetic Resonance Spectroscopy (1H-MRS) can be used to detect cerebral metabolites including N-acetylaspartate (NAA),creatine (Cr) and choline (Ch). Hence,clinical applications of this method for neuropediatric diseases can be expected. However,regarding neuronal migration disorders,there have been only a few reported studies. We therefore examined the lH-MRS in six patients with migration disorders,ages ranged from 8months to 28years 10months with a mean of 10years 10months. Investigation was performed using Magnetom H15 (Siemens) with a repetition time of 1500 msec and an echo time of 270msec. The ratio of NAA/Cr,Ch/Cr were examined. The volume of interest with the size of 2 × 2 × 2 ~ 3 × 3 × 5cm3 was chosen in the area including lesions,and a contralateral area without lesions was also investigated. Results were as follows. 1) The ratio of NAA/Cr was low in the area with lesions in all 6cases; 1.41,1.95,2.27 and 1.71 in cases with heterotopic gray matter,0.99 in one case with polymicrogyria,an d 1.30 in one case with hemimegalencephaly,contrasted with a contralataral area without lesions: 1.89, 2.89,2.87,2.55,3.26,2.03,respectively. 2) The ratio of Ch/Cr showed no consistent difference between the area including lesions and contralataral area without lesions. Our findings of a decreased NAA/Cr ratio can be inferred to reflect the decreased numbers of neuronal cell population,or reduced metabolism in the lesions.
Keywords
MR spectroscopy
migration disorder
heterotopic gray matter
polymicrogyria
hemimegalencephaly
Published Date
1999
Publication Title
岡山大学教育学部研究集録
Publication Title Alternative
Bulletin of Faculty of Education, Okayama University
Volume
volume110
Issue
issue1
Publisher
岡山大学教育学部
Publisher Alternative
Faculty of Education, Okayama University
Start Page
29
End Page
34
ISSN
0471-4008
NCID
AN00032875
Content Type
Departmental Bulletin Paper
language
日本語
File Version
publisher
Refereed
False
Eprints Journal Name
bgeou