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ID 53003
FullText URL
Author
Tomotsuka, Naoto
Kaku, Ryuji Kaken ID
Obata, Norihiko
Matsuoka, Yoshikazu Kaken ID researchmap
Kanzaki, Hirotaka
Taniguchi, Arata
Muto, Noriko
Omiya, Hiroki
Itano, Yoshitaro
Sato, Tadasu
Ichikawa, Hiroyuki
Mizobuchi, Satoshi
Abstract
Metastatic bone cancer causes severe pain, but current treatments often provide insufficient pain relief. One of the reasons is that mechanisms underlying bone cancer pain are not solved completely. Our previous studies have shown that brain-derived neurotrophic factor (BDNF), known as a member of the neurotrophic family, is an important molecule in the pathological pain state in some pain models. We hypothesized that expression changes of BDNF may be one of the factors related to bone cancer pain; in this study, we investigated changes of BDNF expression in dorsal root ganglia in a rat bone cancer pain model. As we expected, BDNF mRNA (messenger ribonucleic acid) and protein were significantly increased in L3 dorsal root ganglia after intra-tibial inoculation of MRMT-1 rat breast cancer cells. Among the eleven splice-variants of BDNF mRNA, exon 1–9 variant increased predominantly. Interestingly, the up-regulation of BDNF is localized in small neurons (mostly nociceptive neurons) but not in medium or large neurons (non-nociceptive neurons). Further, expression of nerve growth factor (NGF), which is known as a specific promoter of BDNF exon 1–9 variant, was significantly increased in tibial bone marrow. Our findings suggest that BDNF is a key molecule in bone cancer pain, and NGF-BDNF cascade possibly develops bone cancer pain.
Keywords
BDNF
bone cancer pain
chronic pain
nerve growth factor
Published Date
2014-07-11
Publication Title
Journal of Pain Research
Volume
volume7
Start Page
415
End Page
423
Content Type
Journal Article
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/52959
language
英語
Copyright Holders
This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php
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Refereed
True
DOI