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ID 53064
FullText URL
Author
Kobayashi, Satoru
Kobayashi, Naoya
Fujiwara, Toshiyoshi ORCID Kakenhi
Abstract
Background/Aims: PuraMatrix is a synthetic material consisting of 16-amino acid peptides that self-assemble into nanofibers, previously used as a scaffold for functional cell cultures. We conducted a clinical study to determine the safety and sealing properties of PuraMatrix in post-operative lymphorrhea following pelvic surgery in humans. Methodology: A total of 20 patients who underwent rectal cancer resection were analyzed. The study group (n = 10) consisted of patients who received PuraMatrix, matched with a control group (n = 10) of patients operated on conventionally. Results: During the 2 to 3 month follow-up period, there were no abnormal findings or adverse events in any the patients who received PuraMatrix. We found that the patients who received PuraMatrix had significantly reduced post-operative drainage volumes compared with the patients in the control group. Conclusions: PuraMatrix is a safe and effective bio-compatible sealing material for the management of post-operative peritoneal effusion following pelvic surgery.
Keywords
Peritoneal effusion
Nanofiber polypeptide
Lymphorrhea
Pelvic surgery
Published Date
2014-03
Publication Title
Hepato-Gastroenterology
Volume
volume61
Issue
issue130
Start Page
349
End Page
353
ISSN
0172-6390
Content Type
Journal Article
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/51449
language
英語
File Version
author
Refereed
True
Web of Sience KeyUT