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ID 11836
Eprint ID
11836
FullText URL
Thumnail K003341.pdf 301 KB
Title Alternative
口腔癌における染色体2q21-37部位の微調欠失マッピング
Author
Cengiz, Beyhan
Abstract
We analysed the loss of heterozygosity (LOH) of long arm of chromosome 2 by using 16 polymorphic microsatellite markers in 39 matched oral normal and cancer tissues, and defined the deletional mapping of the region with putative tumor suppressor genes. LOH was detected at least one location in 33 of 39 (85%) tumor tissues. Frequent deletions were detected at the locations of microsatellite markers, D2S2304 (35%), D2S111 (40%), D2S155 (35%), D2S1327 (29%), D2S164 (29%), D2S125 (68%) and D2S140 (32%). Three preferentially deleted regions at 2q21-24, 2q33-35 and 2q37.3 were observed. Several candidate tumor suppressor genes in these regions such as LRP1B, CASP8, CASP10, BARD1, ILKAP, PPP1R7, and ING5, are located. Further molecular analysis of each gene should be performed to clarify their roles in oral carcinogenesis.
Keywords
Oral cancer
2q
2q21-24
2q33-35
2q37.3
Loss of heterozygosity
ING5
CASP8
Note
http://dx.doi.org/10.1016/j.oraloncology.2006.03.004
Published Date
2007-03-23
Publication Title
Content Type
Thesis or Dissertation
Grant Number
甲第3341号
Granted Date
2007-03-23
Thesis Type
博士(学術)
Grantor
岡山大学
Official Url
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16857411&dopt=Abstract
language
日本語
File Version
none
Refereed
Unknown