ID | 11700 |
Eprint ID | 11700
|
FullText URL | |
Title Alternative | ヒスタミンN-メチル基転移酵素阻害薬,アモジアキンのP. acnes-LPS誘発性肝炎におよぼす効果
|
Author |
Yokoyama, Akira
|
Abstract | We examined whether treatment with amodiaquine, a potent inhibitor of histamine N-methyltransferase protects mice from Propionibacterium acnes (P. acnes)-primed and lipopolysaccharide (LPS)-induced hepatitis. The subcutaneous injection of amodiaquine (2 and 5 mg/kg) significantly increased the histamine levels in the liver in comparison to saline treated mice. Pretreatment with amodiaquine also improved the survival rate of the hepatitis mice, and this improvement was partially associated with the decrease in serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Amodiaquine partially suppressed increases of tumor necrosis factor (TNF)-alpha in the serum and TNF-alpha mRNA expression in the liver, whereas the expression of interleukin (IL)-18, interferon (IFN)-gamma and IL-12 in the liver was not changed by amodiaquine treatment. In conclusion, the present findings suggested that the elevation of endogenous histamine by amodiaquine may thus play a protective role through the regulation of TNF-alpha production in endotoxin-induced hepatic injury mice.
|
Keywords | Amodiaquine
Propionibacterium acnes
Lipopolysaccharide
Hepatitis
|
Note | http://dx.doi.org/10.1016/j.ejphar.2006.11.033
|
Published Date | 2007-03-23
|
Publication Title | |
Content Type |
Thesis or Dissertation
|
Grant Number | 甲第3308号
|
Granted Date | 2007-03-23
|
Thesis Type |
Doctor of Philosophy in Medical Science
|
Grantor | 岡山大学
|
Official Url | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17222819&dopt=Abstract
|
language |
Japanese
|
File Version | none
|
Refereed |
Unknown
|