このエントリーをはてなブックマークに追加
ID 2198
Eprint ID
2198
FullText URL
Thumnail K001945.pdf 161 KB
Title Alternative
実験的高血圧モデルにおける陰茎血管の構造変化について
Author
岡部 浩典
Abstract
In hypertension, small arteries in a variety of vascular beds undergo structural changes that increase resistance. To assess whether there are differential structural changes in the penis that accompany hypertension, we began with determining structurally-based vascular resistance properties in penile and hindlimb vascular beds of adult spontaneously hypertensive rats (SHR) and Sprague-Dawley (SD) rats. In anesthetized SHR, the penile and hindlimb vasculature were isolated and perfused, maximum dilation was induced, and a flow-pressure assessment and alpha 1-adrenoceptor agonist concentration-response curves were generated. Both the baseline and maximum constrictor responses were similar in the two beds of each strain, and overall the maximum structurally-based vascular resistance in SHR was higher than in SD rats. Our data suggests that the penile vasculature is not protected from the structural changes that take place in the other vascular beds in hypertension. There does not appear to be an underlying functional control mechanism that protects the penile vasculature from structural changes that may have a negative impact on penile blood flow.
Keywords
erectile dysfunction
hypertension
structural change
penile vasculature
spontaneously hypertensive rats
Note
掲載順位 73 ; http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10404281&dopt=Abstract
Published Date
1999-03-31
Publication Title
Content Type
Thesis or Dissertation
Grant Number
甲第1945号
Granted Date
1999-03-31
Thesis Type
博士(医学)
Grantor
岡山大学
Official Url
http://www.nature.com/ijir/journal/v11/n3/pdf/3900394a.pdf
language
日本語
File Version
none
Refereed
Unknown