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ID 16149
Eprint ID
16149
FullText URL
Thumnail 97_289.pdf 660 KB
Title Alternative
Induction Chemotherapy for Acute Leukemia Part 2. Clinical Evaluation of the Streptococcal Preparation, OK-432, in Induction Chemotherapy for Acute Nonlymphocytic Leukemia (ANLL)
Author
Yorimitsu, Seiichi
Abstract
In this study NCMP (neocarzinostatin, cytosine arabinoside, 6-mercaptopurine and prednisolone) two-step regimen with OK-432 was applied, to patients with ANLL in order to evaluate the clinical effects of the streptococcal preparation, OK-432. A total of 33 cases were randomized into two groups. Group A and group B were treated with NCMP two-step and NCMP two-step with OK-432, respectively. Group A consisted of 19 patients (16 AML and 3 AMoL) and group B consisted of 14 patients (13 AML and one AMMoL). All patients were previously untreated. The complete remission (CR) rate was 66.7% in group A and 64.3% in group B. However, patients in group B attained M(1) marrow and CR earlier than those in group A. Cytoreduction in peripheral blood and bone marrow was more rapidly obtained in group B than in group A. Normal hematopoiesis recovered more rapidly in group B than in group A. Cellular immunity (PPD) in group B tended to be maintained more than in group A. The CR rate in relapsed cases was higher in group B than in group A (44% vs 14%). Fever related to OK-432 was recognized in group B, but it was tolerable. OK-432 showed no prophylactic effects on infection. The simultaneous combination of OK-432 with chemotherapeutic agents might be expected to rapidly reduce leukemic cells, accelerate recovery of normal hematopoiesis and maintain cellular immunity during induction chemotherapy for ANLL.
Keywords
急性白血病寛解導入療法
造血能賦活剤
溶連菌製剤OK-432
Published Date
1985-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume97
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
289
End Page
299
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/97/3-4/97_3-4_289/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma