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ID 16147
Eprint ID
16147
FullText URL
Thumnail 97_277.pdf 1.32 MB
Title Alternative
Induction Chemotherapy for Acute Leukemia Part 1. Effects of the streptococcal preparation, OK-432, on autologous CFUs in mice and on hematopoietic disorders induced by anti-leukemic agents
Author
Yorimitsu, Seiichi
Abstract
The streptococcal preparation, OK-432, has been found to be a biological response modifier. The effects of OK-432 on autologous CFUs in mice and hematopoietic disorders induced by anti-leukemic agents (DNR: daunorubicin, ara-C: cytosine arabinoside, NCS: neocarzinostatin) were investigated in order to obtain information as to the possibility of its clinical application in induction chemotherapy for acute leukemia. OK-432 increased autologous CFUs in irradiated mice, suggesting that it acted hematopoietically on multipotent stem cells. In mice treated with DNR, OK-432 reduced neutropenia when it was given before and simultaneously with DNR. In mice pretreated with OK-432, the duration of neutropenia caused by ara-C tended to be prolonged. On the other hand, simultaneous administration of OK-432 with ara-C showed no significant differences as compared to ara-C alone. These results suggested that the simultaneous administration of OK-432 with chemotherapeutic agents might protect normal hematopoiesis during induction chemotherapy for acute leukemia in man.
Keywords
溶連菌製剤OK-432
造血能賦活剤
マウスautologous CFUs
Published Date
1985-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume97
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
277
End Page
287
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/97/3-4/97_3-4_277/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma