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ID 52028
FullText URL
Author
Wakabayashi, Taketoshi
Matsumoto, Kumiko
Kosaka, Jun
Abstract
We investigated whether the use of vascularized peripheral nerve grafts on the optic nerve stump enhances axonal regeneration of retinal ganglion cells compared with isolated nonvascularized grafts. The rat median nerve was microsurgically sutured with its supplying artery and vein to the optic nerve stump. The number of retinal ganglion cells with regenerating axons was evaluated by retrograde labeling into the grafted peripheral nerve, and the myelination of the regenerating axon fibers was examined by electron microscopy. The number of retinal ganglion cells with regenerating axons was significantly higher in the vascularized graft than in the nonvascularized graft. The ratio of myelinated axon fibers was also increased in vascularized grafts. Thus, grafting with their supplying arteries and veins to an injured nerve stump represents a promising strategy to accelerate axonal regeneration from neurons of the central nervous system.
Keywords
graft
microsurgery
optic nerve
retinal ganglion cells
Schwann cells
vascularized nerve
Published Date
2013-07-10
Publication Title
NeuroReport
Volume
volume24
Issue
issue10
Start Page
566
End Page
571
ISSN
0959-4965
Content Type
Journal Article
Official Url
http://dx.doi.org/10.1097/WNR.0b013e3283625b39
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/51959
language
英語
Copyright Holders
(C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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author
Refereed
True
DOI
Web of Sience KeyUT