JaLCDOI 10.18926/AMO/30446
FullText URL fulltext.pdf
Author Tanaka, Michio| Inatsuchi, Shuji| Terasaki, Teiichi| Funaki, Jun| Bandou, Tsuyosi| Shimada, Kazuhiko| Wakabayashi, Hiroyuki| Kubota, Yoshiki| Watanabe, Akiharu|
Abstract <p>Clinical studies show that patients with liver cirrhosis associated with portal hypertension have a high incidence of duodenal ulcer and duodenitis. However, little information is available concerning pathophysiological process of such duodenal diseases in liver cirrhosis. Hemodynamics of the duodenal mucosa was studied in cirrhotics with esophageal varices (68 cases) and in noncirrhotics with non-ulcer dyspepsia (37 cases) as well. In each group, hemoglobin concentration in the peripheral venous blood was measured, and mucosal hemodynamics was examined in 4 regions of the duodenum by endoscopic reflectance spectrophotometer. No significant intergroup difference was noted in the mean age or sex ratio. Hemoglobin concentration in the peripheral venous blood was significantly lower (p less than 0.01) in the cirrhotics. There were no significant intergroup differences in duodenal mucosal blood volume. However, the cirrhotics showed significantly lower oxygen saturation of hemoglobin in all regions of the duodenum (p less than 0.01). These results show that the cirrhotics with esophageal varices had relative increase in blood volume and decrease in oxygen saturation of hemoglobin in the duodenal mucosa. Such microcirculatory disturbances seem to predispose liver cirrhosis patients to duodenal injury.</p>
Keywords liver cirrhosis portal hypertension duodenal mucosa reflectance spectrophotometry duodenoscopy
Amo Type Article
Published Date 1990-10
Publication Title Acta Medica Okayama
Volume volume44
Issue issue5
Publisher Okayama University Medical School
Start Page 273
End Page 277
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 2260499
Web of Sience KeyUT A1990EG00700007