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ID 52015
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Author
Toyota, Teruaki
Nishiyama, Yuichi
Abstract
We previously reported that radon inhalation activates antioxidative functions in the liver and inhibits carbon tetrachloride-induced hepatopathy in mice. In addition, it has been reported that reactive oxygen species contribute to alcohol-induced hepatopathy. In this study, we examined the inhibitory effects of radon inhalation on acute alcohol- induced hepatopathy in mice. C57BL/6J mice were subjected to intraperitoneal injection of 50% alcohol (5 g/kg bodyweight) after inhaling approximately 4000 Bq/m(3) radon for 24 h. Alcohol administration significantly increased the activities of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) in serum, and the levels of triglyceride and lipid peroxide in the liver, suggesting acute alcohol- induced hepatopathy. Radon inhalation activated antioxidative functions in the liver. Furthermore, pretreatment with radon inhibited the depression of hepatic functions and antioxidative functions. These findings suggested that radon inhalation activated antioxidative functions in the liver and inhibited acute alcohol- induced hepatopathy in mice.
Published Date
2012
Publication Title
Mediators of Inflammation
Volume
volume2012
ISSN
0962-9351
Content Type
Journal Article
Official Url
http://dx.doi.org/10.1155/2012/382801
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/51997
language
英語
Copyright Holders
© 2012 Teruaki Toyota et al.
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Refereed
True
DOI