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ID 48716
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Author
Sakoda, Akihiro
Yoshimoto, Masaaki
Nakagawa, Shinya
Toyota, Teruaki
Nishiyama, Yuichi
Yamato, Keiko
Ishimori, Yuu
Abstract
Our previous studies showed the possibility that activation of the antioxidative function alleviates various oxidative damages, which are related to lifestyle diseases. Results showed that, low-dose X-ray irradiation activated superoxide dismutase and inhibits oedema following ischaemia-reperfusion. To alleviate ischaemia-reperfusion injury with transplantation, the changes of the antioxidative function in liver graft using low-dose X-ray irradiation immediately after exenteration were examined. Results showed that liver grafts activate the antioxidative function as a result of irradiation. In addition, radon inhalation enhances the antioxidative function in some organs, and alleviates alcohol-induced oxidative damage of mouse liver. Moreover, in order to determine the most effective condition of radon inhalation, mice inhaled radon before or after carbon tetrachloride (CCl4) administration. Results showed that radon inhalation alleviates CCl4-induced hepatopathy, especially prior inhalation. It is highly possible that adequate activation of antioxidative functions induced by low-dose irradiation can contribute to preventing or reducing oxidative damages, which are related to lifestyle diseases.
Published Date
2011-07
Publication Title
Radiation Protection Dosimetry
Volume
volume146
Issue
issue1-3
Publisher
Oxford University Press
Start Page
360
End Page
363
ISSN
0144-8420
NCID
AA10627673
Content Type
Journal Article
Official Url
http://rpd.oxfordjournals.org/content/146/1-3/360.long
language
英語
Copyright Holders
© The Author 2011. Published by Oxford University Press. All rights reserved.
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Refereed
True
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