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ID 48707
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Author
Sakoda, Akihiro
Ishimori, Yuu
Toyota, Teruaki
Nishiyama, Yuichi
Tanaka, Hiroshi
Abstract
We examined dose–dependent or dose rate–dependent changes of superoxide dismutase (SOD) activity using a new large-scale facility for exposing small animals to radon. Mice were exposed to radon at a concentration of 250, 500, 1000, 2000, or 4000 Bq/m3 for 0.5, 1, 2, 4, or 8 days. When mice were exposed to radon at 2000 day•Bq/m3, activation of SOD activities in plasma, liver, pancreas, heart, thymus, and kidney showed dose–rate effects. Our results also suggested that continuous exposure to radon increased SOD activity, but SOD activity transiently returned to normal levels at around 2 days. Moreover, we classified the organs into four groups (1. plasma, brain, lung; 2. heart, liver, pancreas, small intestine; 3. kidney, thymus; 4. stomach) based on changes in SOD activity. Thymus had the highest responsiveness and stomach had lowest. These data provide useful baseline measurements for future studies on radon effects.
Keywords
Radon
Superoxide dismutase
Dose
Dose rate
Large-scale facility
Published Date
2011-11-22
Publication Title
Journal of Radiation Research
Volume
volume52
Issue
issue6
Publisher
Journal of Radiation Research Editorial Committee
Start Page
775
End Page
781
ISSN
0449-3060
NCID
AA00705792
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/jrr/52/6/52_10072/_article
language
英語
Copyright Holders
Copyright © 2011 by Journal of Radiation Research Editorial Committee
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publisher
Refereed
True
DOI
PubMed ID
Web of Sience KeyUT