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ID 48556
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Author
Yoshimoto, Masaaki
Toyota, Teruaki
Abstract
We examined the inhibitory effects of low-dose X-irradiation on mouse brain tissue with cold-induced injury by comparing tissue samples from three groups of mice: control, sham-irradiated cold-exposed, and X-ray-irradiated (0.5 Gy) cold-exposed mice. The water content in brain increased significantly in the sham-irradiated group following the cold-induced injury relative to the control group. However, water content in brain tissue from the X-ray-irradiated group was significantly lower than that from the sham-irradiated group. Levels of antioxidants, such as superoxide dismutase and glutathione, in brain tissue from the X-ray-irradiated group were higher than those from the sham-irradiated group. Moreover, the cold injury-induced cell death, particularly apoptosis, while low-dose irradiation inhibited cell death, especially among glial cells, but not numeral cells. These findings suggest that prior low-dose X-irradiation activated antioxidant function and inhibited cold-induced brain injury.
Keywords
cold injury
brain edema
0.5 Gy irradiation
antioxidative function
Published Date
2012-02-01
Publication Title
Inflammation
Volume
volume35
Issue
issue1
Publisher
Springer Science+Business Media, LLC
Start Page
89
End Page
97
ISSN
0360-3997
Content Type
Journal Article
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/48543
language
英語
Copyright Holders
© Springer Science+Business Media, LLC 2011
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Unknown
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