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ID 15889
Eprint ID
15889
FullText URL
Thumnail 99_303.pdf 363 KB
Title Alternative
Studies on gastric mucosal lesions in liver damage Part1 : An experimental study using rat models
Author
Sugihara, Toru
Abstract
Gastric mucosal lesions such as gastric ulcers and erosions are frequently observed in patients with liver cirrhosis. Although portal hypertension is suggested to play a role in the development of gastric mucosal lesions, the pathogenesis still remains undisclosed. Gastric mucosal blood flow (BF), potential difference (PD) and prostaglandin E(2)(PGE(2)) were analyzed using both rats with liver injury induced by carbon tetraoxide and rats with portal hypertension induced by incomplete portal occlusion. BF, PD and PGE(2) were lower in the rats with injured liver and with portal hypertension than in control rats. BF and PD were lower in the rats with injured liver than in the rats with portal hypertension. These results support the view that the impairment of the defensive factors of gastric mucosa represented by BF, PD and PGE(2) play an important role in the pathogenesis of gastric mucosal lesions in rats with injured liver. Portal hypertension was considered to be a factor contributing to the impairment of the defensive factors of gastric mucosa.
Keywords
肝障害
胃粘膜障害
胃粘膜血流
potential difference
prostaglandin E(2)
Published Date
1987-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume99
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
303
End Page
309
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/99/3-4/99_3-4_303/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma