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ID 16803
Eprint ID
16803
FullText URL
Thumnail 94_503.pdf 665 KB
Title Alternative
A study of the extramedullary hemopoiesis in adult mouse liver relating to age and sex.
Author
Mori, Masaharu
Kirizuka, Keizi
Nakamoto, Shu
Sadahira, Yoshito
Awai, Michiyasu
Seno, Satimaru
Abstract
Active extramedullary hemopoiesis developed in liver of adult female mice by blood depletion of splenectomized animals. Observations were made on adult C(3)H/He mice, males and females of 6 weeks and 6 months old. The mice were splenectomized and the blood was depleted by 0.6ml/once 20days after splenectomy. The hematocrit value decreased to about 30% at 2days after blood depletion and recovered to near normal level after 10days. No significant differences were observed in the hematocrit value in all the animals observed. Reticulocyte counts increased to 20-28% 4-6days after blood depletion with rapid decrease for the following 4days and then returned to the normal level 25-30days after depletion. The maximum level of reticulocyte counts was highest in aged females(28% ) and lowest in young males(20% ). The number of hemopoietic foci in liver observed on HE stained tissue sections showed a marked difference in each group. Male animals, both young and aged, developed no hemopoietic foci. Females developed many foci in liver, higher values in aged females than young ones. Discussion was made on the reason why aged females developed a large number of foci in liver.
Keywords
肝髄外造血
マウス
週令
Published Date
1982-06-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume94
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
503
End Page
507
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/94/5-6/94_5-6_503/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma