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ID 14639
Eprint ID
14639
FullText URL
Thumnail 078_649.pdf 1010 KB
Author
Nishikaze, Keiko
Abstract
The mitochondria isolated from ascites tumor cells have a specific characteristic different from those isolated from normal liver cells, i. e. they do not react with ferrous ion, GSH with GSSG and ascorbic acid, showing no increase in lipid peroxide formation and no swelling. From the viewpoint that this characteristic of tumor cell mitochondria may be due to the specific liqid. compositions of mitochondrial membrane, the author tried to analyze the components of liqids of tumor cells comparing with those of brain, liver, heart, kidney and spleen from normal animals. The following have been revealed; 1. The tumor cells are very low in peroxide formation in the presence of the reducing agents comparing to those from the normal tissues, though the grade of peroxide formation is different in each tissues and by the agents used, and is rather lower in homogenate than in intact mitochondria. 2. Chemical analysis revealed that the lipids from tumor cells is low in unsaturated fatty acid contents, especially C20-polyene contents than those from normal cells. This will be responsible for the low level in lipid peroxidation of the tumor cells. 3. On the basement of the these results discussions has been made on the lipid peroxidation of mitochondria of tumor cells and related mitochondrial swelling under the consideration of enzymic activities.
Note
学位番号 乙第230号
Published Date
1966-05-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume78
Issue
issue4-5
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
649
End Page
654
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/78/4-5/78_4-5_649/_article/-char/ja/
Related Url
http://eprints.lib.okayama-u.ac.jp/4454/
http://eprints.lib.okayama-u.ac.jp/14636/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma