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ID 18380
Eprint ID
18380
FullText URL
Thumnail 77_1257.pdf 622 KB
Title Alternative
Studies on Treatment of Bronchial Asthma with Chloroquine and it's Pharmacological Actions Part. 3. Studies on Fibroblast-inhibiting Action of Chloroquine
Author
Moritani, Yoshiaki
Abstract
The effects of chloroquine on the growth and oxygen consumption of cultured fibroblasts were investigated. 1) Chloroquine diphosphate inhibited the growth of chick embryo heart fibroblasts in tissue culture medium containing 5γ/dl and also other chloroquine derivatives such as chloroquine diorotate, chloroquine chondroitine sulfate, chloroquine polygalacturonate showed same result in medium containing 2γ/dl of chloroquine too. 2) Furthermore, chloroquine diphosphate inhibited the growth of L strain cell in tissue culture medium containing 2γ/dl of chloroquine. 3) Effects of chloroquine on respiratory functions were observed in L strain cells with using Warburg's apparate, showing a decrease of oxygen consumption of the cells in the concertration of 2γ/dl of chloroquine. 4) Also fibroblast-inhibiting action was observed by administrating several drugs in the cultured chick embryo heart fibroblasts. The growth of the cells was not influenced by ACTH administration but several drugs such as tetrahydroxyquinone, phytonadione or oxophenarsine hydrochloride, arsphenamine sodium as well as prednisolone showed considerably potent fibroblast-inhibiting action. As mentioned above marked inhibition of the growth of fibroblasts was definitely demonstrated by chloroquine administration and this fibroblast-inhibiting action of chloroquine is thought to be important mechanisum of action to the treatment of bronchial asthma with lung fibrosis.
Published Date
1965-09-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume77
Issue
issue8-9
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1257
End Page
1265
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/77/8-9/77_8-9_1257/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma