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ID 18667
Eprint ID
18667
FullText URL
Thumnail 72_1615.pdf 366 KB
Title Alternative
Effect of High Hydrostatic Pressure on Smooth Muscle Part Ⅱ. Effect of some drugs on the longitudinal muscle of frog intestine
Author
Miki, Hukuziro
Abstract
High hydrostatic pressure (50 to 500 kg/㎠) was applied to isolated longitudinal muscle strip (10 to 15 mm long, 2 to 3 mm wide) of frog intestine immersed in Ringer's solution containing some drugs, and from the observation of changes of the tonus and rhythmical movement of the preparation following results were obtained. 1) When a drug acts upon the strip during compression, such as magnesium sulfate, barium chloride, acetylcholine or atropine sulfate, the changes on the strip result in algebraic summation of the pressure- and drug-effects. But the action of adrenaline chloride on the strip is reversed under high hydrostatic pressure. Namely, the movement of the strip inhibited by adrenaline or pressure respectively, but it is augumented when the pressure is applied on the strip immersed in the adrenaline-Ringer's solution. 2) The stimulative effect on the muscle strip under high hydrostatic pressure up to 100 kg/㎠ is of neurogenic nature. But under pressure from 300 to 500 kg/㎠ the first instaneous lengthening of the strip and successive slow shortening are observed and this effect is of myogenic nature. 3) The temporary contraction of the strip immediately after decompression may be considered as an adaptive process in biological phenomenon.
Published Date
1960-10-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume72
Issue
issue8-10
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1615
End Page
1621
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/72/8-10/72_8-10_1615/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma