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ID 56676
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Author
Ghosh, Arjun Division of Parasitology, National Institute of Cholera & Enteric Diseases
Karmakar, Sumallya Division of Parasitology, National Institute of Cholera & Enteric Diseases
Mukherjee, Avik K. Division of Parasitology, National Institute of Cholera & Enteric Diseases
Raj, Dibyendu Division of Parasitology, National Institute of Cholera & Enteric Diseases
Das, Koushik Division of Parasitology, National Institute of Cholera & Enteric Diseases
Sarkar, Srimanti Department of Biochemistry, Bose Institute
Nozaki, T. Department of Parasitology, National Institute of Infectious Diseases, Japan and Graduate School of Life and Environmental Sciences, University of Tsukuba
Ganguly, Sandipan Division of Parasitology, National Institute of Cholera & Enteric Diseases
Abstract
Small nuclear Ribonucleo Protein F (snRNP F) is a spliceosomal protein that binds with U1, U2, U4/U6 and U5 small nuclear RNA (snRNA) to form spliceosomal complexes responsible for pre mRNA processing. This study reports the unusual interaction of giardial snRNP F with small nucleolar RNAs (snoRNA) that are responsible for pre rRNA processing. Electrophoretic Mobility Shift Assay was used to demonstrate the interaction of this protein with U3 and U14 class snoRNA of the early branching eukaryote Giardia lamblia. It was also evident from our study that snRNP F in Giardia is evolutionary distinct from its other eukaryotic orthologues.
Keywords
Giardia lamblia
snRNA
snoRNA
U3
U14
Published Date
2013
Publication Title
Global Journal of Biology, Agriculture & Health Sciences
Volume
volume2
Issue
issue3
Publisher
Longdom Publishing
Start Page
178
End Page
184
ISSN
23195584
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
File Version
publisher
Project
Collaborative Research of Okayama University for Infectious Diseases in India