JaLCDOI 10.18926/AMO/30544
FullText URL fulltext.pdf
Author Takahashi, Isao| Hara, Masamichi| Adachi, Tomiro| Takaoka, Kazuko| Sakano, Makoto| Lai, Miinyuh| Kohi, Fumikazu| Yorimitsu, Seiichi| Tokioka, Masaaki| Kitajima, Koichi| Kimura, Ikuro| Sanada, Hiroshi|
Abstract <p>Twelve patients with refractory acute leukemia (7 patients with acute myelocytic leukemia and 5 patients with acute lymphocytic leukemia) were treated with a new anthracycline antibiotic, aclacinomycin-A (ACM). ACM was administrated by intravenous drip infusion at a dose of 20 mg/day for 7 or 14 days and this was repeated after at least 7 days. Four of 12 patients (33.3%) achieved a complete remission; 3 of 7 acute myelocytic leukemia (42.8%) and 1 of 5 acute lymphocytic leukemia (20.0%). The days required for achieving the complete remission ranged from 23 to 78 days (median: 61) and the total doses of ACM used from 180 to 500 mg (median: 310), and the durations of complete remission from 11 to 28+ weeks (median: 21+). The untoward effects on digestive organs, such as nausea, vomiting and anorexia, and hematological toxicities were frequently seen; however, they were controlled by supportive treatment. Alopecia was not observed. Arrythmia was recognized in one patient at the initiation of ACM infusion with complete remission without withdrawal of ACM. These results suggest that ACM is a potentially effective anthracycline antibiotic in the clinical management of acute leukemia.</p>
Keywords aclacinomycin-A leukemia chemotherapy
Amo Type Brief Note
Published Date 1980-11
Publication Title Acta Medica Okayama
Volume volume34
Issue issue5
Publisher Okayama University Medical School
Start Page 349
End Page 354
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6449134
Web of Sience KeyUT A1980KT96800007
JaLCDOI 10.18926/AMO/30519
FullText URL fulltext.pdf
Author Lai, Miinyuh| Hamasaki, Kazuhide| Tokioka, Masaaki| Tsubota, Teruhiko| Nakata, Yasunari| Kitajima, Koichi| Kimura, Ikuro| Sanada, Hiroshi|
Abstract <p>A 30 year old female patient diagnosed as acute lymphoblastic leukemia (ALL) with hand mirror like configuration of lymphoblastic-lymphocytic cells is reported. Although the leukemia was resistant to conventional chemotherapeutic regimens, the patient always looked well and survived for more than 20 months. Surface marker analysis showed that the cell was non-T, non-B, and not reactive to antiserum against common ALL antigen. A cytogenetic study of all the analyzable metaphases of the direct bone marrow preparation had a normal female karyotype. The clinical and hematological course is described. The immunological significance and the influence of hand mirror cell on chemosensitivity and prognosis are discussed.</p>
Keywords acute lymphoblastic leukemia hand mirror cell leukemia.
Amo Type Brief Note
Published Date 1980-09
Publication Title Acta Medica Okayama
Volume volume34
Issue issue4
Publisher Okayama University Medical School
Start Page 283
End Page 287
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6452031
Web of Sience KeyUT A1980KK16800007