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ID 48282
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Author
Yamamoto, Dai
Ghosh, Souvik
Ganesh, Balasubramanian
Krishnan, Triveni
Chawla-Sarkar, Mamta
Alam, Mohammed Mahbub
Aung, Tin Sabai
Kobayashi, Nobumichi
Abstract
Group B rotavirus (GBR) is a rare enteric pathogen that causes severe diarrhoea, primarily in adults. Nearly full-length sequences of all 11 RNA segments were determined for human GBRs detected recently in India (IDH-084 in 2007, IC-008 in 2008), Bangladesh (Bang117 in 2003) and Myanmar (MMR-B1 in 2007), and analysed phylogenetically with the sequence data of GBRs reported previously. All RNA segments of GBR strains from India, Bangladesh and Myanmar showed >95 % nucleotide sequence identities. Among the 11 RNA segments, the VP6 and NSP2 genes showed the highest identities (>98 %), whilst the lowest identities were observed in the NSP4 gene (96.1 %), NSP5 gene (95.6 %) and VP8*-encoding region of the VP4 gene (95.9 %). Divergent or conserved regions in the deduced amino acid sequences of GBR VP1–VP4 and NSP1–NSP5 were similar to those in group A rotaviruses (GARs), and the functionally important motifs and structural characteristics in viral proteins known for GAR were conserved in all of the human GBRs. These findings suggest that, whilst the degree of genetic evolution may be dependent on each RNA segment, human GBR may have been evolving in a similar manner to GAR, associated with the similar functional roles of individual viral proteins.
Published Date
2010-07
Publication Title
Journal of General Virology
Volume
volume91
Issue
issue7
Start Page
1772
End Page
1781
ISSN
0022-1317
NCID
AA00698722
Content Type
Journal Article
Project
Collaborative Research of Okayama University for Infectious Diseases in India
Official Url
http://vir.sgmjournals.org/content/91/7/1772
language
英語
Copyright Holders
© 2010 SGM
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Refereed
True
DOI
PubMed ID
Web of Sience KeyUT