JaLCDOI 10.18926/AMO/32449
FullText URL fulltext.pdf
Author Kawaguchi, Kenji| Itoshima, Tatsuya| Ukida, Minoru| Ito, Toshio| Kiyotoshi, Shozo| Ogawa, Hiromichi| Hattori, Shuzo| Kitadai, Masahiro| Mizutani, Shigeki| Nagashima, Hideo|
Abstract <p>The incidence of intraperitoneal adhesion after abdominal surgery was studied. Peritoneoscopy was performed in 933 patients with liver diseases over the 6 year 5 month period from March 1974 to July 1980. Of the patients, 352 (37.7%) had undergone an abdominal operation, and intraperitoneal adhesion was detected in 205 (58.2%) of these patients. The liver was not observable in 5 out of 61 patients with adhesions after upper abdominal operations. Whereas, the liver was clearly observable in patients with lower abdominal operations in spite of adhesions. Out of the 581 patients without any abdominal operations, 30 patients (5.2%) had adhesions in the abdominal cavity, and 6 of them had extensive adhesions that partially obscured the observation of liver surface. In all patients, peritoneoscopy was performed without complications by avoiding the surgical scar for puncture sites and ensuring a free air lumen before trocar puncture.</p>
Keywords peritoneoscopy liver adhesion abdominal operation
Amo Type Article
Published Date 1983-02
Publication Title Acta Medica Okayama
Volume volume37
Issue issue1
Publisher Okayama University Medical School
Start Page 67
End Page 72
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6221509
Web of Science KeyUT A1983QD83600008
JaLCDOI 10.18926/AMO/32448
FullText URL fulltext.pdf
Author Ogawa, Hiromichi| Itoshima, Tatsuya| Ito, Toshio| Kiyotoshi, Syozo| Kawaguchi, Kenji| Kitadai, Masahiro| Hattori, Syozo| Mizutani, SHigeki| Ukida, Minoru| Tobe, Kazuo| Nagashima, Hideo| Kobayashi, Toshinari|
Abstract <p>Absence of Kupffer cells in rat liver hyperplastic nodules induced by a chemical carcinogen was demonstrated by intravenous injection of indian ink. Hyperplastic nodules appeared 4 weeks after diethylnitrosamine (DEN) was administered, and the nodules continued growing and became eosinophilic hyperplastic nodules after 5 to 6 weeks. After intravenous injection of indian ink, hyperplastic nodules were observed as carbon-free white nodules, which were macroscopically distinguishable from the black surrounding tissue. As observed by light microscopy, Kupffer cells were absent in hyperplastic nodules in contrast to being present in the surrounding tissue. Scanning electron microscopy confirmed these findings and furthermore revealed that the sinusoidal endothelium of hyperplastic nodules had no fenestrae. Injection of indian ink is a useful method for delineation and enucleation of hyperplastic nodules in the study of morphological and chemical changes of nodules.</p>
Keywords liver hyperplastic nodule kupffer cell chemical carcinogenesis indian ink
Amo Type Article
Published Date 1983-02
Publication Title Acta Medica Okayama
Volume volume37
Issue issue1
Publisher Okayama University Medical School
Start Page 79
End Page 84
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6846054
Web of Science KeyUT A1983QD83600010
JaLCDOI 10.18926/AMO/32444
FullText URL fulltext.pdf
Author Shiota, Tetsuya| Watanabe, Akiharu| Mitani, Ken| Ito, Toshio| Tobe, Kazuo| Nagashima, Hideo|
Abstract <p>A patient with an unresectable hepatocellular carcinoma (HCC) who survived without active treatment 3 years and 8 months after histological diagnosis is described. The size of the liver, which was already quite huge at the time of diagnosis, changed little during the entire clinical observation. However, 2 months before death, his condition deteriorated rapidly following gastrointestinal bleeding due to the direct invasion of the stomach by HCC. A critical reason for the unusually long-term survival of the patient may stem from the facts that a well-differentiated and bile-producing HCC was extent in most encapsulated-tumor tissues and that liver cirrhosis was not present.</p>
Keywords hepatocellular carcinoma long-term survival well-differenciated type hepatobiliary scintigraphy
Amo Type Article
Published Date 1983-02
Publication Title Acta Medica Okayama
Volume volume37
Issue issue1
Publisher Okayama University Medical School
Start Page 73
End Page 78
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6189368
Web of Science KeyUT A1983QD83600009
JaLCDOI 10.18926/AMO/32398
FullText URL fulltext.pdf
Author Ito, Toshio| Yamamoto, Hiroshi| Itoshima, Tatsuya| Ukida, Minoru| Ogawa, Hiromichi| Kitadai, Masahiro| Hattori, Shuzo| Mizutani, Shigeki| Kita, Keiji| Tanaka, Ryoji| Yamauchi, Yasuhiko| Hashimoto, Keiji| Hayashi, Hidehiro| Aono, Kaname| Nagashima, Hideo|
Abstract <p>Computed tomographic arteriography (CTA) was performed in 30 patients with hepatocellular carcinoma (HCC). Detection of HCC by CTA was compared with that of conventional celiac or hepatic arteriography. CT scanning was performed immediately, 30 seconds and 1 min after an injection of 5 to 10 ml of contrast medium into the common or proper hepatic artery. Repeated infusions allowed whole liver sections to be visualized. HCC was localized in 28 of the 30 patients by conventional arteriography, with CTA detecting the masses in 27 of the 28 patients. CTA imaging presented the tumor mass in 1 of the 2 patients missed by arteriography. Conventional arteriography delineated the boundaries of HCC in 15 (50%) of the 30 patients. CTA clearly delineated the masses in 26 (87%) of the 30 patients including 11 patients in which the tumor borders were obscure by conventional arteriography. HCC lesions smaller than 1 cm in diameter were detected only by CTA in 6 (20%) of the patients. It was concluded that CTA is both useful and necessary in the demarcation of small HCC masses.</p>
Keywords computed tomographic arteriography hepatocellular carcinoma hepatic arteriography contrast enhancement
Amo Type Article
Published Date 1983-12
Publication Title Acta Medica Okayama
Volume volume37
Issue issue6
Publisher Okayama University Medical School
Start Page 503
End Page 510
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6320600
Web of Science KeyUT A1983RW62800006
JaLCDOI 10.18926/AMO/31602
FullText URL fulltext.pdf
Author Kakio, Takeshi| Ito, Toshio| Sue, Kunihiko| Sakaguchi, Kosaku| Shiota, Tetsuya| Oka, Takahiko| Kobayashi, Haruhiko| Sakai, Nobubyuki| Omoto, Masaki| Mikami, Masayuki| Nakanishi, Sousuke| Kawamoto, Hirohumi| Omori, Nobuhiko|
Abstract <p>Obliteration for gastric or duodenal variceal hemorrhage was performed via transileocoecal or transhepatic portal catheterization in 8 patients with portal hypertension. The patients were 6 men and 2 women, whose average age was 59 years. All of the patients had cirrhosis of the liver. The obliteration was performed as an emergency procedure in 6 cases, and 2 patients were electively treated. Transileocoecal obliteration (TIO) and transhepatic obliteration (PTO) were selected for 6, and 2 patients, respectively. Variceal bleeding was successfully controlled in all patients after completion of the therapy. One patient died after 3 months when duodenal variceal bleeding recurred. Elective surgical operations were performed on 2 patients after the initial therapy, because the vein feeding toward the varices remained. Six of the patients have survived to date without bleeding. Transient oliguria and jaundice after the therapy were noticed in 2 patients. Histological examination revealed cast formation of polymerized cyanoacrylate in the obliterated gastric varices of 2 patients. TIO and PTO seem to be safe, effective procedures to stop bleeding from ectopic varices, gastric or duodenal. This therapy is useful either to obtain accurate information about the varices or to obliterate the collateral veins in patients with ruptured ectopic varices.</p>
Keywords cardial varices duodenal varices portal hypertension variceal obliteration cyanoacrylate
Amo Type Article
Published Date 1993-02
Publication Title Acta Medica Okayama
Volume volume47
Issue issue1
Publisher Okayama University Medical School
Start Page 39
End Page 43
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8460553
Web of Science KeyUT A1993KP18500007
JaLCDOI 10.18926/AMO/31586
FullText URL fulltext.pdf
Author Kakio, Takeshi| Ito, Toshio| Sue, Kunihiko| Tanimizu, Masahito| Tsuji, Takao|
Abstract <p>A simulation model to predict the survival probability of individual patients with hepatocellular carcinoma (HCC) after therapy was derived from the results of various therapies and follow-up studies of 450 HCC patients. Twenty-two prognostically important variables were analyzed by Cox's proportional hazards model. The 9 significant variables that were extracted were used to build the simulation. In this model, S(t), the expected estimated survival rate for individual patient at time t (month), is calculated by the following equation: S(t) = (exp (-0.03655t) (exp [0.9479 ([portal vein invasion]-0.222) + 0.3846 ([tumor number]-2.00) + 0.2578 ([tumor size]-3.231) + 0.0742 ([loge AFP]-5.647) + 0.8184 ([metastasis]-0.036) + 0.2810 ([Child's class]-1.689)-0.7088 ([transcatheter arterial embolization]-0.578)-0.9746 ([percutaneous ethanol injection]-0.153)-0.5377 ([hepatectomy]-0.109)]) The validity of the model was assessed using a split-sample technique. This paper does not discuss the superiority or inferiority of the therapies, because some selection bias for prognostic factors among the therapies can not be completely excluded. But this model is proposed as a practical model to predict the survival of patients with HCC.</p>
Keywords hepatocellular carcinoma prognosis multrivariate analysis Cox's proportional hazards model simulation model
Amo Type Article
Published Date 1993-10
Publication Title Acta Medica Okayama
Volume volume47
Issue issue5
Publisher Okayama University Medical School
Start Page 339
End Page 346
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8273457
Web of Science KeyUT A1993ME47100008
JaLCDOI 10.18926/AMO/31539
FullText URL fulltext.pdf
Author Kitadai, Masahiro| Itoshima, Tatsuya| Hattori, Shuzo| Ukida, Minoru| Ito, Toshio| Ogawa, Hiromichi| Mizutani, Shigeki| Tanaka, Ryoji| Kita, Keiji| Nagashima, Hideo|
Abstract <p>Sixty-seven cases of alcoholic liver disease were histologically classified into 4 groups: alcoholic liver cirrhosis (ALC), alcoholic hepatitis (AH), alcoholic liver fibrosis (ALF) and alcoholic fatty liver (AFL). They were statistically reclassified by the likelihood method using age, total alcohol intake, hepatomegaly and 12 liver function tests. A score table for likely diagnosis was constructed from the incidences of each range. The cases were re-evaluated using the score table, with an overall correct diagnosis rate of 73%. The best combination of 5 parameters included the indocyanine green plasma disappearance rate, total alcohol intake, cholesterol, choline esterase and glutamic oxaloacetic transaminase/glutamic pyruvic transaminase ratio. A correct diagnosis rate of 75% was attained using these 5 parameters, and 94% of patients were correctly diagnosed by the first or the second likelihood diagnosis. Differential diagnosis of alcoholic liver diseases was easily and confidently obtained with the likelihood score table.</p>
Keywords alcoholic liver diseases multivariate analaysis liver function tests
Amo Type Article
Published Date 1985-02
Publication Title Acta Medica Okayama
Volume volume39
Issue issue1
Publisher Okayama University Medical School
Start Page 11
End Page 18
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 3984778
Web of Science KeyUT A1985ACS5600002
JaLCDOI 10.18926/AMO/31518
FullText URL fulltext.pdf
Author Tanaka, Ryoji| Itoshima, Tatsuya| Ukida, Minoru| Ito, Toshio| Kitadai, Masahiro| Hattori, Shuzo| Mizutani, Shigeki| Kita, Keiji| Nagashima, Hideo|
Abstract <p>Three linear plots by which the liver's maximum removal rate (Rmax) of indocyanine green (ICG) and the Michaelis constant (Km) can be calculated were compared in a microcomputer simulation study. The widely-used Lineweaver-Burk plot (1/V vs. 1/S; V, ICG initial removal rate (mg/kg/min); S, ICG loading dose (mg/kg] presented the greatest bias and variance. There was no remarkable difference in bias between the S/V vs. S plot and the V vs. V/S plot, but the latter possessed a smaller variance. Therefore, the V vs. V/S plot was considered the best for estimating Rmax. The best combination of three ICG loading doses was 0.5, 2, and 5 mg/kg. This combination was selected by comparison of the Rmax estimated from three points with that estimated from six points (0.5, 1, 2, 3, 4 and 5 mg/kg).</p>
Keywords indocyanine green liver's maximum removal rate liver function test simulation study
Amo Type Article
Published Date 1985-04
Publication Title Acta Medica Okayama
Volume volume39
Issue issue2
Publisher Okayama University Medical School
Start Page 119
End Page 124
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 4003111
Web of Science KeyUT A1985AGK4600006
JaLCDOI 10.18926/AMO/31514
FullText URL fulltext.pdf
Author Kitadai, Masahiro| Hattori, Shuzo| Itoshima, Tatsuya| Ukida, Minoru| Ito, Toshio| Ogawa, Hiromichi| Mizutani, Shigeki| Kita, Keiji| Tanaka, Ryoji| Nagashima, Hideo|
Abstract <p>Peritoneoscopic findings of 39 patients with alcoholic liver cirrhosis (ALC) were compared with those of 95 patients with non-alcoholic liver cirrhosis (NALC). They were selected from 245 patients with liver cirrhosis subjected to peritoneoscopy in the 7 year period from 1975 to 1981. Out of the 95 NALC patients, 24 had hepatitis B surface antigen. The ALC patients had nodules which varied in size (61%), large depressions (69%), and a markedly rounded edge of the liver (33%) more often than NALC patients (18, 43 and 3%, respectively). Nodularity differed between the right and left lobes in ALC (41%) more often than in NALC (16%). Interstitial reddish markings and patchy nodules were, however, more frequent in NALC (51 and 28%, respectively) than in ALC (8 and 5%, respectively). Lymphatic vesicles were observed both in ALC (85%) and NALC (78%). In conclusion, the peritoneoscopic features which suggested ALC were the coexistence of nodules of various sizes, large depressions and a markedly dull edge of the liver. Interstitial reddish markings and patchy nodules were more indicative of NALC than ALC.</p>
Keywords peritoneoscopy alcoholic liver cirrhosis non-alcoholic liver cirrhosis
Amo Type Article
Published Date 1985-04
Publication Title Acta Medica Okayama
Volume volume39
Issue issue2
Publisher Okayama University Medical School
Start Page 105
End Page 112
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 3159179
Web of Sience KeyUT A1985AGK4600004
JaLCDOI 10.18926/AMO/30687
FullText URL fulltext.pdf
Author Shimamura, Junnosuke| Taketa, Kazuhisa| Ito, Toshio| Shimada, Yoshihiro| Nagashima, Hideo|
Abstract <p>Urinary excretion of cyclic GMP (cGMP) and the plasma level of cyclic AMP (cAMP) were determined in patients with liver diseases. The urinary excretion of cGMP, expressed on the basis of creatinine excreted per day, was at significantly higher levels not only in primary hepatoma but also in liver cirrhosis, while the plasma level of cAMP was higher only in liver cirrhosis. Thus, the ratio of urinary cGMP excretion to plasma cAMP level in primary hepatoma was significantly higher than that in liver cirrhosis. In cirrhotic patients studied by catheterization, the level of cGMP in the hepatic vein was significantly lower than that in the superior mesenteric or portal vein, indicating the uptake of cGMP by the liver. Since cGMP excretion correlated with KICG both in liver cirrhosis and primary hepatoma, the increased cGMP excretion appeared to be explained by a reduced uptake of cGMP by the liver.</p>
Keywords urinary cGMP plasma cAMP hepatitis liver cirrhosis hepatoma
Amo Type Article
Published Date 1982-10
Publication Title Acta Medica Okayama
Volume volume36
Issue issue5
Publisher Okayama University Medical School
Start Page 331
End Page 340
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6295071
Web of Science KeyUT A1982PN03500002
JaLCDOI 10.18926/AMO/30683
FullText URL fulltext.pdf
Author Ito, Toshio| Itoshima, Tatsuya| Kiyotoshi, Shuzo| Kawaguchi, Kenji| Ogawa, Hiromichi| Kitadai, Masahiro| Hattori, Shuzo| Maruyama, Toshihiro| Tomoda, Jun| Morichika, Shigeru| Munetomo, Fumio| Nagashima, Hideo|
Abstract <p>Percutaneous transhepatic portal catheterization was performed in 68 cases of liver diseases in the 2 year period from 1978 to 1980. The Chiba University method was modified. Portal vein catheterization was successful in 61 cases (90%). Selective splenic vein catheterization was successful in 55 of the 61 cases (90%) and selective superior mesenteric vein catheterization in 59 cases (97%). The liver was punctured an average of 4.6 times in order to successfully insert the catheter into the main portal vein, and the number of punctures was less than 10 in 57 of the 61 cases (93%). The portal vein pressure was 310+/-67 mm H2O in idiopathic portal hypertension (8 cases), 290+/-83 in liver cirrhosis (33 cases), 193+/-71 in chronic hepatitis (7 cases) and 166+/-50 in fatty liver (4 cases). Portal vein pressure rose from 205+/-75 to 380+/-55 mm H2O in 11 cases after forced Valsalva maneuver. No major complications were encountered.</p>
Keywords percutaneous transhepatic portal catheterization(PTP) portal vein pressure portal hypertension forced Valsalva maneuver
Amo Type Article
Published Date 1982-04
Publication Title Acta Medica Okayama
Volume volume36
Issue issue2
Publisher Okayama University Medical School
Start Page 147
End Page 156
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 7136852
Web of Science KeyUT A1982NM45300008
JaLCDOI 10.18926/AMO/30653
FullText URL fulltext.pdf
Author Ito, Toshio| Itoshima, Tatsuya| Ukida, Minoru| Kiyotoshi, Shozo| Kawaguchi, Kenji| Ogawa, Hiromichi| Hattori, Shuzo| Kitadai, Masahiro|
Abstract <p>The portal vein system was clearly visualized in superior mesenteric arterial portography using prostaglandin E1. Angiographic examination was performed in 68 patients with various liver diseases during the 2 year period from 1980 to 1981. Twenty microgram of prostaglandin E1 was injected into the superior mesenteric artery 30 seconds before injection of 60 ml of contrast medium. The main portal vein was visualized in all of 68 cases. A high rate of success for visualization of the intrahepatic portal vein system by prostaglandin E1 was achieved. The first branches of the intrahepatic portal vein were visualized in 100% of the cases, the second branches in 82%, the third branches in 44%, and the fourth branches in 4% in the right portal vein system. In the left portal vein system, the first branches were visualized in 87%, the second branches in 41%, and the third branches in 3% of the cases. The intrahepatic portal vein system was more clearly visualized in females than in males (P less than 0.05). This procedure is simple, safe and useful for clear visualization of the portal vein system.</p>
Keywords superior mesenteric arteriography arterial portography portal vein system prostaglandin E1
Amo Type Article
Published Date 1982-08
Publication Title Acta Medica Okayama
Volume volume36
Issue issue4
Publisher Okayama University Medical School
Start Page 291
End Page 297
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6890302
Web of Science KeyUT A1982PE61100006
JaLCDOI 10.18926/AMO/30416
FullText URL fulltext.pdf
Author Kuwahara, Naoaki| Higashi, Toshihiro| Nouso, Kazuhiro| Ito, Toshio| Tsuji, Takao|
Abstract <p>Tissue PIVKA-II was examined in 32 hepatocellular carcinomas and 2 metastatic liver tumors using indirect immunofluorescence, and the results were compared with the size, histological grading and serum PIVKA-II level. The specificity of this method was confirmed by the disappearance of reactivity in PLC/PRF/5 cells after the addition of vitamin K to the culture medium. Positive PIVKA-II staining was observed as a clustered or a single cell pattern only in the HCC nodules, but not in the surrounding cirrhotic tissue. PIVKA-II staining was observed in all HCC groups regardless of histological grade. There was no relationship between PIVKA-II staining and the size of HCC. PIVKA-II was detected immunohistochemically even in small HCC of patients whose plasma PIVKA-II levels were below the detection limit. These results suggest that PIVKA-II production is a specific phenotype of HCC regardless of its histological grading and demonstrate that this immunofluorescent PIVKA-II staining is more sensitive and useful than plasma PIVKA-II assay for the diagnosis of HCC.</p>
Keywords hepatocellular carcinoma PIVKA-??immunofluorescent staining tumor marker
Amo Type Article
Published Date 1995-02
Publication Title Acta Medica Okayama
Volume volume49
Issue issue1
Publisher Okayama University Medical School
Start Page 19
End Page 24
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 7762405
Web of Science KeyUT A1995QK32500003
JaLCDOI 10.18926/AMO/30369
FullText URL fulltext.pdf
Author Ito, Toshio| Itoshima, Tatsuya| Ukida, Minoru| Tobe, Kazuo| Kiyotoshi, Shozo| Kawaguchi, Keiji| Ogawa, Hiromichi| Yamamoto, Harumi| Hattori, Shuzo| Kitadai, Masahiro| Mizutani, Shigeki| Tsuchiya, Takahiro| Kita, Keiji| Tanaka, Ryoji| Nagasima, Hideo|
Abstract <p>The whole body including extended processes of Ito's fat-storing cells was observed by scanning electron microscopy in rat liver injured with lithocholic acid (LCA). Necrotic foci developed in the midlobular zone 48 h after LCA administration. Demonstration of Ito cell bodies around the foci was probably facilitated by easy detachment of hepatocytes from Ito cells. The body and the processes were located mainly between the sinusoidal endothelium and hepatocytes; sometimes they were between hepatocytes. Ito cells often were proximate to collagen fiber bundles and sometimes were attached to them. The cell body was flatly round or elliptic, 7 to 12 micron in diameter. Its surface was finely undulated with microvillous projections about 0.1 micron in length. Branching patterns of the processes resembled a fern-leaf mantling the sinusoidal endothelium. The trunks of the processes were about 2 micron in diameter and 20-30 micron in length. These processes tapered, branching into thinner processes, with the most peripheral being 0.1 micron in diameter. Ito cells and their branching processes likely strengthen sinusoidal walls and control blood flow in the sinusoids.</p>
Keywords ito cell fat-storing cell lithocholic acied liver cell necrosis scanning electron microscopy
Amo Type Article
Published Date 1984-02
Publication Title Acta Medica Okayama
Volume volume38
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 9
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6702480
Web of Science KeyUT A1984SF03000001
JaLCDOI 10.18926/AMO/30366
FullText URL fulltext.pdf
Author Itoshima, Tatsuya| Ito, Toshio| Ukida, Minoru| Ogawa, Hiromichi| Kitadai, Masahiro| Hattori, Shunzo| Mizutani, Shigeki| Kita, Keiji| Tanaka, Ryoji| Koide, Norio| Nagashima, Hideo|
Abstract <p>Experimental hepatocellular carcinoma (HCC) in rats did not take up intravenously administered indocyanine green (ICG) and trypan blue, while surrounding tissue did. The lack of ICG uptake was also observed by peritoneoscopy in patients with HCC. The contrast between ICG-stained cirrhotic nodules and HCC tumors was intensified with infrared photography. Non-uptake of dyes by HCC cells may enable discrimination between tumors and normal cells.</p>
Keywords indocyanine green hepatocellular carcinoma peritoneoscopy trypan blue
Amo Type Article
Published Date 1984-02
Publication Title Acta Medica Okayama
Volume volume38
Issue issue1
Publisher Okayama University Medical School
Start Page 65
End Page 69
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6322526
Web of Science KeyUT A1984SF03000009
JaLCDOI 10.18926/AMO/30328
FullText URL fulltext.pdf
Author Itoshima, Tatsuya| Kawaguchi, Kenji| Ukida, Minoru| Ito, Toshio| Hattori, Shuzo| Kitadai, Masahiro| Ogawa, Hiromichi| Mizutani, Shigeki| Kita, Keiji| Tanaka, Ryoji| Nagashima, Hideo|
Abstract <p>Sex, age and 21 routine liver function assays were analyzed by stepwise selection and the best-of-all-possible-combinations method to identify a small group of assays valuable in establishing which liver cirrhosis (LC) patients have a high risk of hepatocellular carcinoma (HCC), when alpha-fetoprotein (AFP) is not elevated. Data was obtained from 115 HCC and 122 LC patients on admission. Tumor size correlated with AFP (0.73), alkaline phosphatase (ALP, 0.47), leucine aminopeptidase (LAP, 0.42), lactic dehydrogenase (LDH, 0.42), and the glutamic oxaloacetic transaminase (GOT)/glutamic pyruvic transaminase (GPT) ratio (GOT/GPT, 0.41). The mean of the correct diagnosis rates (CDR) of HCC and LC utilizing AFP as the sole parameter (89%) was markedly higher than those of the other parameters. The best-of-all-possible-combinations method presented a more powerful combination than stepwise selection. The best combination of 7 parameters (LAP, GOT/GPT, choline esterase, one-hour erythrocyte sedimentation rate, age, albumin/globulin ratio, and total bilirubin) presented a mean CDR of 80%, HCC CDR of 77%, and false positive rate of 18%. LC patients statistically diagnosed as having HCC by these 7 parameters are proposed as high risk patients. Fourteen (78%) of 18 HCC patients who were AFP-negative were statistically diagnosed. This analysis can be applied to LC patients to distinguish those that should be followed closely by imaging diagnostic techniques.</p>
Keywords hepatocellular carcinoma liver cirrhosis high risk hepatocellular carcinoma liver function tests differentical diagnosis
Amo Type Article
Published Date 1984-04
Publication Title Acta Medica Okayama
Volume volume38
Issue issue2
Publisher Okayama University Medical School
Start Page 159
End Page 168
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6203337
Web of Science KeyUT A1984SN81800007
JaLCDOI 10.18926/AMO/30323
FullText URL fulltext.pdf
Author Kitadai, Masahiro| Hattori, Shuzo| Itoshima, Tatsuya| Ukida, Minoru| Ito, Toshio| Ogawa, Hiromichi| Mizutani, Shigeki| Kita, Keiji| Tanaka, Ryoji| Nagashima, Hideo|
Abstract <p>Sake or bourbon (8g ethanol/kg body weight) was intragastrically administered to rats for 12 days. An equal dose of ethanol in water or an isocaloric glucose solution was administered to control groups. Food was withheld, but water freely provided. Neither mortality nor liver and body weights were different between the alcohol-treated groups. Glutamic oxaloacetic transaminase and glutamic pyruvic transaminase were more elevated in the sake group than in the other groups. Additionally, liver fibrosis was more pronounced, and vacuole formation or steatosis was less in this group. These results suggest that sake is more fibrogenic. Some components other than ethanol, such as long-alkyl chain alcohols, may have been responsible for the differential histopathology.</p>
Keywords alcoholic liver injury alcoholic beverages alcoholic liver fibrosis longchain alcohols rats
Amo Type Article
Published Date 1984-12
Publication Title Acta Medica Okayama
Volume volume38
Issue issue6
Publisher Okayama University Medical School
Start Page 493
End Page 499
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6524445
Web of Science KeyUT A1984TX98000001