JaLCDOI 10.18926/AMO/52790
FullText URL 68_4_243.pdf
Author Wada, Nozomu| Yasunaka, Tetsuya| Ikeda, Fusao| Nishina, Sohji| Korenaga, Masaaki| Hino, Keisuke| Fujioka, Shin-ichi| Osawa, Toshiya| Itoshima, Tatsuya| Kawanaka, Miwa| Yamada, Gotaro| Kariyama, Kazuya| Takayama, Hiroki| Kubota, Junichi| Morimoto, Yoichi| Mizushima, Takaaki| Yamashita, Haruhiko| Tanioka, Hiroaki| Negoro, Yuji| Toshimori, Junichi| Kobashi, Haruhiko| Hirano, Atsushi| Itano, Yasuo| Takaki, Akinobu| Yamamoto, Kazuhide|
Abstract Hepatitis B virus (HBV) is one of the major viruses causing acute hepatitis. Recently, the incidence of acute hepatitis with genotype A has been increasing in Japan. The aim of this study was to investigate acute hepatitis B (AHB) in Okayama prefecture, with special attention to HBV genotype A. AHB patients who visited one of 12 general hospitals in Okayama prefecture between 2006 and 2010 were retrospectively analyzed. Over the course of the study period, 128 patients were diagnosed with AHB. Sexual transmission was supposed in the majority of patients (78 patients, 61%), including 59 (76%) having sex with heterosexual partners. The genotypes of HBV were assessed in 90 patients (70%), of whom 27 patients were infected with genotype A, 5 with genotype B, and 58 with genotype C. The prevalence of genotype A was significantly higher among male patients (28.7%), aged 20-29 (35.6%, p<0.01), among men who had sex with men (100%, p<0.005), and among patients having sex with unspecified partners (44.8%, p<0.005). Genotype A was not a significant factor associated with delayed HBsAg disappearance. Caution should be exercised with regard to sexually transmissible diseases in order to slow the pandemic spread of AHB due to genotype A.
Keywords acute hepatitis hepatitis B virus
Amo Type Original Article
Published Date 2014-08
Publication Title Acta Medica Okayama
Volume volume68
Issue issue4
Publisher Okayama University Medical School
Start Page 243
End Page 247
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25145410
Web of Science KeyUT 000340687500006
JaLCDOI 10.18926/AMO/32449
FullText URL fulltext.pdf
Author Kawaguchi, Kenji| Itoshima, Tatsuya| Ukida, Minoru| Ito, Toshio| Kiyotoshi, Shozo| Ogawa, Hiromichi| Hattori, Shuzo| Kitadai, Masahiro| Mizutani, Shigeki| Nagashima, Hideo|
Abstract <p>The incidence of intraperitoneal adhesion after abdominal surgery was studied. Peritoneoscopy was performed in 933 patients with liver diseases over the 6 year 5 month period from March 1974 to July 1980. Of the patients, 352 (37.7%) had undergone an abdominal operation, and intraperitoneal adhesion was detected in 205 (58.2%) of these patients. The liver was not observable in 5 out of 61 patients with adhesions after upper abdominal operations. Whereas, the liver was clearly observable in patients with lower abdominal operations in spite of adhesions. Out of the 581 patients without any abdominal operations, 30 patients (5.2%) had adhesions in the abdominal cavity, and 6 of them had extensive adhesions that partially obscured the observation of liver surface. In all patients, peritoneoscopy was performed without complications by avoiding the surgical scar for puncture sites and ensuring a free air lumen before trocar puncture.</p>
Keywords peritoneoscopy liver adhesion abdominal operation
Amo Type Article
Published Date 1983-02
Publication Title Acta Medica Okayama
Volume volume37
Issue issue1
Publisher Okayama University Medical School
Start Page 67
End Page 72
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6221509
Web of Science KeyUT A1983QD83600008
JaLCDOI 10.18926/AMO/32448
FullText URL fulltext.pdf
Author Ogawa, Hiromichi| Itoshima, Tatsuya| Ito, Toshio| Kiyotoshi, Syozo| Kawaguchi, Kenji| Kitadai, Masahiro| Hattori, Syozo| Mizutani, SHigeki| Ukida, Minoru| Tobe, Kazuo| Nagashima, Hideo| Kobayashi, Toshinari|
Abstract <p>Absence of Kupffer cells in rat liver hyperplastic nodules induced by a chemical carcinogen was demonstrated by intravenous injection of indian ink. Hyperplastic nodules appeared 4 weeks after diethylnitrosamine (DEN) was administered, and the nodules continued growing and became eosinophilic hyperplastic nodules after 5 to 6 weeks. After intravenous injection of indian ink, hyperplastic nodules were observed as carbon-free white nodules, which were macroscopically distinguishable from the black surrounding tissue. As observed by light microscopy, Kupffer cells were absent in hyperplastic nodules in contrast to being present in the surrounding tissue. Scanning electron microscopy confirmed these findings and furthermore revealed that the sinusoidal endothelium of hyperplastic nodules had no fenestrae. Injection of indian ink is a useful method for delineation and enucleation of hyperplastic nodules in the study of morphological and chemical changes of nodules.</p>
Keywords liver hyperplastic nodule kupffer cell chemical carcinogenesis indian ink
Amo Type Article
Published Date 1983-02
Publication Title Acta Medica Okayama
Volume volume37
Issue issue1
Publisher Okayama University Medical School
Start Page 79
End Page 84
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6846054
Web of Science KeyUT A1983QD83600010
JaLCDOI 10.18926/AMO/32398
FullText URL fulltext.pdf
Author Ito, Toshio| Yamamoto, Hiroshi| Itoshima, Tatsuya| Ukida, Minoru| Ogawa, Hiromichi| Kitadai, Masahiro| Hattori, Shuzo| Mizutani, Shigeki| Kita, Keiji| Tanaka, Ryoji| Yamauchi, Yasuhiko| Hashimoto, Keiji| Hayashi, Hidehiro| Aono, Kaname| Nagashima, Hideo|
Abstract <p>Computed tomographic arteriography (CTA) was performed in 30 patients with hepatocellular carcinoma (HCC). Detection of HCC by CTA was compared with that of conventional celiac or hepatic arteriography. CT scanning was performed immediately, 30 seconds and 1 min after an injection of 5 to 10 ml of contrast medium into the common or proper hepatic artery. Repeated infusions allowed whole liver sections to be visualized. HCC was localized in 28 of the 30 patients by conventional arteriography, with CTA detecting the masses in 27 of the 28 patients. CTA imaging presented the tumor mass in 1 of the 2 patients missed by arteriography. Conventional arteriography delineated the boundaries of HCC in 15 (50%) of the 30 patients. CTA clearly delineated the masses in 26 (87%) of the 30 patients including 11 patients in which the tumor borders were obscure by conventional arteriography. HCC lesions smaller than 1 cm in diameter were detected only by CTA in 6 (20%) of the patients. It was concluded that CTA is both useful and necessary in the demarcation of small HCC masses.</p>
Keywords computed tomographic arteriography hepatocellular carcinoma hepatic arteriography contrast enhancement
Amo Type Article
Published Date 1983-12
Publication Title Acta Medica Okayama
Volume volume37
Issue issue6
Publisher Okayama University Medical School
Start Page 503
End Page 510
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6320600
Web of Science KeyUT A1983RW62800006
JaLCDOI 10.18926/AMO/31914
FullText URL fulltext.pdf
Author Kitadai, Masahiro| Itoshima, Tatsuya| Nagashima, Hideo|
Abstract <p>The effects of ethanol on rat Kupffer cells were studied functionally and morphologically. Eight g ethanol per kg body weight per day was intragastrically administered to rats for 7 days. An isocaloric glucose solution was administered to control rats. The phagocytic activity of the reticuloendothelial system was measured by the carbon clearance method (57 mg carbon particles per kg body weight) on the 7th day. Kupffer cells having phagocytized carbon particles were counted under the light microscope. Kupffer cells were also observed by scanning electron microscopy. Both the carbon clearance and Kupffer cell number were lower in ethanol-administered rats (32 +/- 8 X 10(-4) mg/ml; 0.6 +/- 0.3/0.01 mm2 liver lobule) as compared to control rats (63 +/- 15; 3.1 +/- 1.0). Microvilli and filopodia of Kupffer cells were fewer in ethanol-administered rats than in control rats. Carbon clearance correlated with Kupffer cell number per 0.01 mm2 liver lobule and liver weight. These results suggest that the decrease in carbon clearance induced by ethanol is due mainly to the decrease in Kupffer cell number and partly to the decrease in Kupffer cell activity as demonstrated by the disappearance of microvilli and filopodia.</p>
Keywords Kupffer cells ethanol carbon clearance scanning electron microscopy rats
Amo Type Article
Published Date 1986-12
Publication Title Acta Medica Okayama
Volume volume40
Issue issue6
Publisher Okayama University Medical School
Start Page 291
End Page 299
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 3825592
Web of Science KeyUT A1986F275800003
JaLCDOI 10.18926/AMO/31539
FullText URL fulltext.pdf
Author Kitadai, Masahiro| Itoshima, Tatsuya| Hattori, Shuzo| Ukida, Minoru| Ito, Toshio| Ogawa, Hiromichi| Mizutani, Shigeki| Tanaka, Ryoji| Kita, Keiji| Nagashima, Hideo|
Abstract <p>Sixty-seven cases of alcoholic liver disease were histologically classified into 4 groups: alcoholic liver cirrhosis (ALC), alcoholic hepatitis (AH), alcoholic liver fibrosis (ALF) and alcoholic fatty liver (AFL). They were statistically reclassified by the likelihood method using age, total alcohol intake, hepatomegaly and 12 liver function tests. A score table for likely diagnosis was constructed from the incidences of each range. The cases were re-evaluated using the score table, with an overall correct diagnosis rate of 73%. The best combination of 5 parameters included the indocyanine green plasma disappearance rate, total alcohol intake, cholesterol, choline esterase and glutamic oxaloacetic transaminase/glutamic pyruvic transaminase ratio. A correct diagnosis rate of 75% was attained using these 5 parameters, and 94% of patients were correctly diagnosed by the first or the second likelihood diagnosis. Differential diagnosis of alcoholic liver diseases was easily and confidently obtained with the likelihood score table.</p>
Keywords alcoholic liver diseases multivariate analaysis liver function tests
Amo Type Article
Published Date 1985-02
Publication Title Acta Medica Okayama
Volume volume39
Issue issue1
Publisher Okayama University Medical School
Start Page 11
End Page 18
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 3984778
Web of Science KeyUT A1985ACS5600002
JaLCDOI 10.18926/AMO/31531
FullText URL fulltext.pdf
Author Yuasa, Shiro| Itoshima, Tatsuya| Ono, Ryosaku| Nagashima, Hideo|
Abstract <p>Problems with infusion therapy for correcting fluid and sodium imbalance in decompensated liver cirrhosis (DLC) were investigated by establishing the safety zone of Talbot et al. for parenteral fluid therapy in 4 DLC patients infused with over 900 ml of fluid each day for at least 9 days. The safety zone was different in each case. The safe infusion volume decreased and the safe electrolyte concentration shifted to a lower osmolality when there was ascites with renal failure than ascites without renal failure. Infusion therapy was performed without deterioration of the water and sodium balance in those patients whose infusion volume and fluid osmolality were in the safety zone. In contrast, ascites retention increased and peripheral edema appeared in patients whose infusion volume and osmolality were out of the safety zone. Therefore, the safety zone should be determined repeatedly during infusion therapy.</p>
Keywords decompensated liver cirrhosis infusion therapy ascites hepatorenal syndrome
Amo Type Article
Published Date 1985-06
Publication Title Acta Medica Okayama
Volume volume39
Issue issue3
Publisher Okayama University Medical School
Start Page 179
End Page 190
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 4024992
Web of Sience KeyUT A1985ALG3300003
JaLCDOI 10.18926/AMO/31518
FullText URL fulltext.pdf
Author Tanaka, Ryoji| Itoshima, Tatsuya| Ukida, Minoru| Ito, Toshio| Kitadai, Masahiro| Hattori, Shuzo| Mizutani, Shigeki| Kita, Keiji| Nagashima, Hideo|
Abstract <p>Three linear plots by which the liver's maximum removal rate (Rmax) of indocyanine green (ICG) and the Michaelis constant (Km) can be calculated were compared in a microcomputer simulation study. The widely-used Lineweaver-Burk plot (1/V vs. 1/S; V, ICG initial removal rate (mg/kg/min); S, ICG loading dose (mg/kg] presented the greatest bias and variance. There was no remarkable difference in bias between the S/V vs. S plot and the V vs. V/S plot, but the latter possessed a smaller variance. Therefore, the V vs. V/S plot was considered the best for estimating Rmax. The best combination of three ICG loading doses was 0.5, 2, and 5 mg/kg. This combination was selected by comparison of the Rmax estimated from three points with that estimated from six points (0.5, 1, 2, 3, 4 and 5 mg/kg).</p>
Keywords indocyanine green liver's maximum removal rate liver function test simulation study
Amo Type Article
Published Date 1985-04
Publication Title Acta Medica Okayama
Volume volume39
Issue issue2
Publisher Okayama University Medical School
Start Page 119
End Page 124
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 4003111
Web of Science KeyUT A1985AGK4600006
JaLCDOI 10.18926/AMO/31514
FullText URL fulltext.pdf
Author Kitadai, Masahiro| Hattori, Shuzo| Itoshima, Tatsuya| Ukida, Minoru| Ito, Toshio| Ogawa, Hiromichi| Mizutani, Shigeki| Kita, Keiji| Tanaka, Ryoji| Nagashima, Hideo|
Abstract <p>Peritoneoscopic findings of 39 patients with alcoholic liver cirrhosis (ALC) were compared with those of 95 patients with non-alcoholic liver cirrhosis (NALC). They were selected from 245 patients with liver cirrhosis subjected to peritoneoscopy in the 7 year period from 1975 to 1981. Out of the 95 NALC patients, 24 had hepatitis B surface antigen. The ALC patients had nodules which varied in size (61%), large depressions (69%), and a markedly rounded edge of the liver (33%) more often than NALC patients (18, 43 and 3%, respectively). Nodularity differed between the right and left lobes in ALC (41%) more often than in NALC (16%). Interstitial reddish markings and patchy nodules were, however, more frequent in NALC (51 and 28%, respectively) than in ALC (8 and 5%, respectively). Lymphatic vesicles were observed both in ALC (85%) and NALC (78%). In conclusion, the peritoneoscopic features which suggested ALC were the coexistence of nodules of various sizes, large depressions and a markedly dull edge of the liver. Interstitial reddish markings and patchy nodules were more indicative of NALC than ALC.</p>
Keywords peritoneoscopy alcoholic liver cirrhosis non-alcoholic liver cirrhosis
Amo Type Article
Published Date 1985-04
Publication Title Acta Medica Okayama
Volume volume39
Issue issue2
Publisher Okayama University Medical School
Start Page 105
End Page 112
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 3159179
Web of Sience KeyUT A1985AGK4600004
JaLCDOI 10.18926/AMO/31264
FullText URL fulltext.pdf
Author Obata, Takahiro| Watanabe, Akiharu| Hayashi, Shosuku| Takei, Nobuyuki| Sakata, Tatsuro| Shiota, Tetsuya| Higashi, Toshihiro| Itoshima, Tatsuya| Nagashima, Hideo|
Abstract <p>Cholestasis with htperbilirubinemia was induced in female, but not male, Sprague-Dawley rats by daily treatment with phalloidin for 7 days. Increases in serum direct bilirubin level and alkaline phosphatase (Al-Pase) activity were observed concomitantpy with diminished bile flow and a decreased output of bile acid and cholesterol. Kidht microscope findings of the liver revealed proliferated bile ductules and enhanced mitosis of hepatocytes.</p>
Keywords phalloidin cholestasis hyperbilirubinemia mitosis bile ductule.
Amo Type Article
Published Date 1981-12
Publication Title Acta Medica Okayama
Volume volume35
Issue issue6
Publisher Okayama University Medical School
Start Page 411
End Page 415
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6459712
Web of Science KeyUT A1981MV25300004
JaLCDOI 10.18926/AMO/31261
FullText URL fulltext.pdf
Author Obata, Takahiro| Watanabe, Akiharu| Hayashi, Shosaku| Takei, Nobuyuki| Sakata, Tatsuro| Shiota, Tetsuya| Higashi, Toshihiro| Itoshima, Tatsuya| Nagashima, Hideo|
Abstract <p>Cholestasis with hyperbilirubinemia was induced in female, but not male, Sprague-Dawley rats by daily treatment with phalloidin for 7 days. Increases in serum direct bilirubin level and alkaline phosphatase (Al-Pase) activity were observed concomitantly with diminished bile flow and a decreased output of bile acid and cholesterol. Light microscope findings of the liver revealed proliferated bile ductules and enhanced mitosis of hepatocytes.</p>
Keywords phalloidin cholestasis hyperbilirubinemia mitosis bile ductule.
Amo Type Article
Published Date 1981-12
Publication Title Acta Medica Okayama
Volume volume35
Issue issue6
Publisher Okayama University Medical School
Start Page 411
End Page 415
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6459712
Web of Sience KeyUT A1981MV25300004
JaLCDOI 10.18926/AMO/30997
FullText URL fulltext.pdf
Author Yamamoto, Kazuhide| Makino, Yasuhiro| Itoshima, Tatsuya| Kobayashi, Toshinari| Tsuji, Takao|
Abstract <p>Phalloidin, a toxin from the plant Amanita phalloides, irreversibly polymerizes actin filaments and causes cholestasis. Three-dimensional structural changes induced by phalloidin in the bile canaliculi and the intra-acinar localization of these changes were studied in the rat liver by scanning and transmission electron microscopy. After 3 days of treatment, canalicular changes appeared mainly in zones 2 and 3 of Rappaport's acinus, but after 7 days of treatment changes occurred in bile canaliculi of the whole acinus. The changes in the bile canaliculi included tortuosity, saccular dilatation, loss of microvilli, bleb formation and elongation of canalicular side branches. Some side branches extended near to Disse's space, leaving only a thin cytoplasmic rim between the canalicular lumen and Disse's space. Kupffer cells were occasionally situated near such extended bile canaliculi and protruded their processes into the hepatic cord. These results suggest that bile canaliculi in zone 3 are more susceptible to phalloidin toxicity than those in zone 1 and that biliary constituents may leak from such altered bile canaliculi.</p>
Keywords phalloidin bile canaliculi choletasis
Amo Type Article
Published Date 1988-08
Publication Title Acta Medica Okayama
Volume volume42
Issue issue4
Publisher Okayama University Medical School
Start Page 207
End Page 213
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 3177006
Web of Science KeyUT A1988P884600004
JaLCDOI 10.18926/AMO/30852
FullText URL fulltext.pdf
Author Itoshima, Tatsuya| Fedail, Sulieman S.| Suliman, Ikhlas| Ali, Abbas K.| Higashi, Toshihiro| Tsuji, Takao|
Abstract <p>Markers of hepatitis A and B virus were tested in 88 adult Sudanese subjects in Khartoum, Sudan. The subjects consisted of 25 control hospitalized patients, 21 volunteer blood donors, 23 patients with hepatosplenic schistosomiasis, 13 patients with liver cirrhosis and 6 patients with hepatocellular carcinoma (HCC). Antibody to hepatitis A virus was detected in 96% of the total. Hepatitis B surface antigen (HBsAg) was positive in 4, 24, 22, 31, and 67% of the subject groups, respectively. Antibody against hepatitis B core antigen (HBcAb) of undiluted serum was positive in 60, 57, 65, 77 and 83%, and there was no difference in incidence among the groups. It was positive in 200X diluted serum in 4, 24, 17, 23 and 60%. HBsAg and HBcAb (200X) were detected more often in HCC patients than in the control subjects (p less than 0.01). Hepatitis B virus is an important factor in the etiology of HCC in the Sudan.</p>
Keywords hepatitis B virus markers liver cirrhosis hepatocellular carcinoma schistosomiasis Sudan
Amo Type Article
Published Date 1989-08
Publication Title Acta Medica Okayama
Volume volume43
Issue issue4
Publisher Okayama University Medical School
Start Page 241
End Page 244
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 2552752
Web of Science KeyUT A1989AP79100006
JaLCDOI 10.18926/AMO/30683
FullText URL fulltext.pdf
Author Ito, Toshio| Itoshima, Tatsuya| Kiyotoshi, Shuzo| Kawaguchi, Kenji| Ogawa, Hiromichi| Kitadai, Masahiro| Hattori, Shuzo| Maruyama, Toshihiro| Tomoda, Jun| Morichika, Shigeru| Munetomo, Fumio| Nagashima, Hideo|
Abstract <p>Percutaneous transhepatic portal catheterization was performed in 68 cases of liver diseases in the 2 year period from 1978 to 1980. The Chiba University method was modified. Portal vein catheterization was successful in 61 cases (90%). Selective splenic vein catheterization was successful in 55 of the 61 cases (90%) and selective superior mesenteric vein catheterization in 59 cases (97%). The liver was punctured an average of 4.6 times in order to successfully insert the catheter into the main portal vein, and the number of punctures was less than 10 in 57 of the 61 cases (93%). The portal vein pressure was 310+/-67 mm H2O in idiopathic portal hypertension (8 cases), 290+/-83 in liver cirrhosis (33 cases), 193+/-71 in chronic hepatitis (7 cases) and 166+/-50 in fatty liver (4 cases). Portal vein pressure rose from 205+/-75 to 380+/-55 mm H2O in 11 cases after forced Valsalva maneuver. No major complications were encountered.</p>
Keywords percutaneous transhepatic portal catheterization(PTP) portal vein pressure portal hypertension forced Valsalva maneuver
Amo Type Article
Published Date 1982-04
Publication Title Acta Medica Okayama
Volume volume36
Issue issue2
Publisher Okayama University Medical School
Start Page 147
End Page 156
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 7136852
Web of Science KeyUT A1982NM45300008
JaLCDOI 10.18926/AMO/30653
FullText URL fulltext.pdf
Author Ito, Toshio| Itoshima, Tatsuya| Ukida, Minoru| Kiyotoshi, Shozo| Kawaguchi, Kenji| Ogawa, Hiromichi| Hattori, Shuzo| Kitadai, Masahiro|
Abstract <p>The portal vein system was clearly visualized in superior mesenteric arterial portography using prostaglandin E1. Angiographic examination was performed in 68 patients with various liver diseases during the 2 year period from 1980 to 1981. Twenty microgram of prostaglandin E1 was injected into the superior mesenteric artery 30 seconds before injection of 60 ml of contrast medium. The main portal vein was visualized in all of 68 cases. A high rate of success for visualization of the intrahepatic portal vein system by prostaglandin E1 was achieved. The first branches of the intrahepatic portal vein were visualized in 100% of the cases, the second branches in 82%, the third branches in 44%, and the fourth branches in 4% in the right portal vein system. In the left portal vein system, the first branches were visualized in 87%, the second branches in 41%, and the third branches in 3% of the cases. The intrahepatic portal vein system was more clearly visualized in females than in males (P less than 0.05). This procedure is simple, safe and useful for clear visualization of the portal vein system.</p>
Keywords superior mesenteric arteriography arterial portography portal vein system prostaglandin E1
Amo Type Article
Published Date 1982-08
Publication Title Acta Medica Okayama
Volume volume36
Issue issue4
Publisher Okayama University Medical School
Start Page 291
End Page 297
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6890302
Web of Science KeyUT A1982PE61100006
JaLCDOI 10.18926/AMO/30369
FullText URL fulltext.pdf
Author Ito, Toshio| Itoshima, Tatsuya| Ukida, Minoru| Tobe, Kazuo| Kiyotoshi, Shozo| Kawaguchi, Keiji| Ogawa, Hiromichi| Yamamoto, Harumi| Hattori, Shuzo| Kitadai, Masahiro| Mizutani, Shigeki| Tsuchiya, Takahiro| Kita, Keiji| Tanaka, Ryoji| Nagasima, Hideo|
Abstract <p>The whole body including extended processes of Ito's fat-storing cells was observed by scanning electron microscopy in rat liver injured with lithocholic acid (LCA). Necrotic foci developed in the midlobular zone 48 h after LCA administration. Demonstration of Ito cell bodies around the foci was probably facilitated by easy detachment of hepatocytes from Ito cells. The body and the processes were located mainly between the sinusoidal endothelium and hepatocytes; sometimes they were between hepatocytes. Ito cells often were proximate to collagen fiber bundles and sometimes were attached to them. The cell body was flatly round or elliptic, 7 to 12 micron in diameter. Its surface was finely undulated with microvillous projections about 0.1 micron in length. Branching patterns of the processes resembled a fern-leaf mantling the sinusoidal endothelium. The trunks of the processes were about 2 micron in diameter and 20-30 micron in length. These processes tapered, branching into thinner processes, with the most peripheral being 0.1 micron in diameter. Ito cells and their branching processes likely strengthen sinusoidal walls and control blood flow in the sinusoids.</p>
Keywords ito cell fat-storing cell lithocholic acied liver cell necrosis scanning electron microscopy
Amo Type Article
Published Date 1984-02
Publication Title Acta Medica Okayama
Volume volume38
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 9
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6702480
Web of Science KeyUT A1984SF03000001
JaLCDOI 10.18926/AMO/30366
FullText URL fulltext.pdf
Author Itoshima, Tatsuya| Ito, Toshio| Ukida, Minoru| Ogawa, Hiromichi| Kitadai, Masahiro| Hattori, Shunzo| Mizutani, Shigeki| Kita, Keiji| Tanaka, Ryoji| Koide, Norio| Nagashima, Hideo|
Abstract <p>Experimental hepatocellular carcinoma (HCC) in rats did not take up intravenously administered indocyanine green (ICG) and trypan blue, while surrounding tissue did. The lack of ICG uptake was also observed by peritoneoscopy in patients with HCC. The contrast between ICG-stained cirrhotic nodules and HCC tumors was intensified with infrared photography. Non-uptake of dyes by HCC cells may enable discrimination between tumors and normal cells.</p>
Keywords indocyanine green hepatocellular carcinoma peritoneoscopy trypan blue
Amo Type Article
Published Date 1984-02
Publication Title Acta Medica Okayama
Volume volume38
Issue issue1
Publisher Okayama University Medical School
Start Page 65
End Page 69
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6322526
Web of Science KeyUT A1984SF03000009
JaLCDOI 10.18926/AMO/30358
FullText URL fulltext.pdf
Author Yuasa, Shiro| Itoshima, Tatsuya| Nagashima, Hideo|
Abstract <p>A comparison was made of the clinical findings of 59 patients with liver cirrhosis (LC) accompanied with hepatocellular carcinoma (HCC) (of which 35 had ascites and 24 did not at the time of admission) and 164 patients with LC, but without HCC (of which 39 had ascites and 125 did not). HCC patients were older and more often had hepatomegaly, vascular spider and pleural effusion than LC patients. Ascites was more frequently observed in HCC than in LC patients when the serum albumin level and the indocyanine green disappearance rate were relatively well maintained and when peripheral edema was absent. There was no difference in the ascitic protein concentration between LC and HCC patients. Malignant cells were detected in ascites only in 14% of the HCC patients. These facts indicate the presence of ascites-inducing factors in HCC patients which have no direct relation to serum colloid osmotic pressure and effective hepatic blood flow. Almost all of the HCC patients with ascites (96%) died with ascites, whereas 54% of the LC patients with ascites recovered from the ascitic condition.</p>
Keywords liver cirrhosis hepatocellular carcinoma ascites
Amo Type Article
Published Date 1984-06
Publication Title Acta Medica Okayama
Volume volume38
Issue issue3
Publisher Okayama University Medical School
Start Page 291
End Page 299
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6087621
Web of Science KeyUT A1984SY25800010
JaLCDOI 10.18926/AMO/30353
FullText URL fulltext.pdf
Author Yuasa, Shiro| Itoshima, Tatsuya| Nagashima, Hideo|
Abstract <p>Resistant ascites was studied in 34 patients with liver cirrhosis and ascites. The patients were initially divided into 3 groups on the basis of the weekly cumulative ascites retention curve: patients relieved of ascites within 3 weeks of admission, patients relieved between 4 and 12 weeks and patients with ascites persisting beyond 13 weeks. &#34;Resistant ascites&#34; was defined as &#34;ascites persisting for more than 13 weeks after admission to the hospital&#34;. The patients were then reclassified into 3 groups : Group A being those patients relieved of ascites within 12 weeks, Group B being those with resistant ascites and group C being those who died within 12 weeks of admission. There were no differences in age and sex distribution, etiology of liver cirrhosis, past medical history or physical findings among the 3 groups. However, Group B had higher levels of serum creatinine and blood urea nitrogen than Group A on admission. Serum bilirubin was higher and serum albumin was lower in Group C than in Group B, which indicates that Group C had greater liver cell failure.</p>
Keywords liver cirrhosis hepatic ascites resistant ascites
Amo Type Article
Published Date 1984-06
Publication Title Acta Medica Okayama
Volume volume38
Issue issue3
Publisher Okayama University Medical School
Start Page 281
End Page 290
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6464804
Web of Science KeyUT A1984SY25800009
JaLCDOI 10.18926/AMO/30328
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Author Itoshima, Tatsuya| Kawaguchi, Kenji| Ukida, Minoru| Ito, Toshio| Hattori, Shuzo| Kitadai, Masahiro| Ogawa, Hiromichi| Mizutani, Shigeki| Kita, Keiji| Tanaka, Ryoji| Nagashima, Hideo|
Abstract <p>Sex, age and 21 routine liver function assays were analyzed by stepwise selection and the best-of-all-possible-combinations method to identify a small group of assays valuable in establishing which liver cirrhosis (LC) patients have a high risk of hepatocellular carcinoma (HCC), when alpha-fetoprotein (AFP) is not elevated. Data was obtained from 115 HCC and 122 LC patients on admission. Tumor size correlated with AFP (0.73), alkaline phosphatase (ALP, 0.47), leucine aminopeptidase (LAP, 0.42), lactic dehydrogenase (LDH, 0.42), and the glutamic oxaloacetic transaminase (GOT)/glutamic pyruvic transaminase (GPT) ratio (GOT/GPT, 0.41). The mean of the correct diagnosis rates (CDR) of HCC and LC utilizing AFP as the sole parameter (89%) was markedly higher than those of the other parameters. The best-of-all-possible-combinations method presented a more powerful combination than stepwise selection. The best combination of 7 parameters (LAP, GOT/GPT, choline esterase, one-hour erythrocyte sedimentation rate, age, albumin/globulin ratio, and total bilirubin) presented a mean CDR of 80%, HCC CDR of 77%, and false positive rate of 18%. LC patients statistically diagnosed as having HCC by these 7 parameters are proposed as high risk patients. Fourteen (78%) of 18 HCC patients who were AFP-negative were statistically diagnosed. This analysis can be applied to LC patients to distinguish those that should be followed closely by imaging diagnostic techniques.</p>
Keywords hepatocellular carcinoma liver cirrhosis high risk hepatocellular carcinoma liver function tests differentical diagnosis
Amo Type Article
Published Date 1984-04
Publication Title Acta Medica Okayama
Volume volume38
Issue issue2
Publisher Okayama University Medical School
Start Page 159
End Page 168
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6203337
Web of Science KeyUT A1984SN81800007