JaLCDOI 10.18926/AMO/32819
FullText URL fulltext.pdf
Author Okamoto, Osamu| Yamamoto, Yuji| Inagaki, Sachiyo| Yoshitome, Kei| ishikawa, Takaki| Imabayashi, Kiyomi| Miyaishi, Satoru| Ishizu, Hideo|
Abstract <p>Allele and genotype frequencies for 15 short tandem repeat (STR) polymorphisms--D3S1358, TH01, D21S11, D18S51, Penta E, D5S818, D13S317, D7S820, D16S539, CSF1PO, Penta D, vWA, D8S1179, TPOX and FGA--in a Japanese population were estimated. No deviations of the observed allele frequency from Hardy-Weinberg equilibrium expectations were found for any of the systems studied. Between 2 new pentanucleotide STR loci, Penta E and Penta D, for which there is only limited data regarding the allelic distribution in Japanese, the Penta E locus was found to be highly polymorphic and exhibited a tri- or tetra-modal distribution pattern having allelic peaks with 5, 11, 15 and 20 repeats. The distribution was significantly different from that of the other ethnic groups. Statistical parameters of forensic importance, the power of discrimination (PD), observed and expected heterozygosity values (H), polymorphism information content (PIC), power of discrimination (PD), matching probability (pM), power of exclusion (PE), and typical paternity index (PI), were calculated for the loci. These parameters indicated the usefulness of the loci in forensic personal identification and paternity testing among Japanese. The systems Penta E, FGA, D18S51 and D8S1179 were the most informative. This method was successfully applied to forensic personal identification and paternity testing among Japanese, thereby confirming its efficacy for forensic practice.</p>
Keywords population data DNA typing short tandem repests personal identification paternity testing
Amo Type Article
Published Date 2003-04
Publication Title Acta Medica Okayama
Volume volume57
Issue issue2
Publisher Okayama University Medical School
Start Page 59
End Page 71
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 12866745
Web of Science KeyUT 000182520400003