JaLCDOI 10.18926/AMO/32399
FullText URL fulltext.pdf
Author Ikeda, Shigemasa| Schwelss, John F|
Abstract <p>Using the ventriculo-cisternal perfusion method, the effects of droperidol and ketamine hydrochloride on cerebrospinal fluid (CSF) production were studied in dogs. Neither droperidol (0.25 mg/kg, IV) nor ketamine (3 mg/kg, IV) caused a statistically significant change in CSF production rate. Positive correlation between CSF production and corresponding cerebral perfusion pressure (CPP) was observed in the ketamine study, whose unfavorable effect on neurosurgical anaesthesia would be obvious. On the other hand droperidol (0.25 mg/kg, IV) tended to decrease CSF production. Droperidol alone or in combination with other analgesics such as fentanyl as currently used in neurosurgical anaesthesia appears to be an appropriate choice in patients with increased intracranial pressure.</p>
Keywords cerebrospinal fluid production ketamine droperidol
Amo Type Article
Published Date 1983-12
Publication Title Acta Medica Okayama
Volume volume37
Issue issue6
Publisher Okayama University Medical School
Start Page 511
End Page 517
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6666678
Web of Science KeyUT A1983RW62800007