Author Miyake, Tomoko| Iwatsuki, Keiji| Hirai, Yoji| Yamamoto, Takenobu| Hamada, Toshihisa| Fujii, Kazuyasu| mamura, Hideaki| Morizane, Shin|
Keywords Epstein-Barr Virus DNA load hydroa vaccniforme hypersensitivity to mosquito bite hemophagocytic lymphohistiocytosis
Note This fulltext is available in Apr. 2021.|
Published Date 2020-04-07
Publication Title Journal of Medical Virology
Publisher Wiley
ISSN 01466615
NCID AA00702400
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 32255500
DOI 10.1002/jmv.25811
Web of Science KeyUT 000528227700001
Related Url isVersionOf https://doi.org/10.1002/jmv.25811
JaLCDOI 10.18926/AMO/56073
FullText URL 72_3_275.pdf
Author Morizane, Shin| Ouchida, Mamoru| Sunagawa, Ko| Sugimoto, Saeko| Kobashi, Mina| Sugihara, Satoru| Nomura, Hayato| Tsuji, Kazuhide| Sato, Atsushi| Miura, Yoshihiro| Hattori, Hiroaki| Tada, Kotaro| Huh, Wook-Kang| Seno, Akemi| Iwatsuki, Keiji|
Abstract Lympho-epithelial Kazal-type-related inhibitor (LEKTI) is a large multidomain serine protease inhibitor that is expressed in epidermal keratinocytes. Nonsense mutations of the SPINK5 gene, which codes for LEKTI, cause Netherton syndrome, which is characterized by hair abnormality, ichthyosis, and atopy. A single nucleotide polymorphism (SNP) of SPINK5, p.K420E, is reported to be associated with the pathogenesis of atopic dermatitis (AD). We studied all 34 exons of the SPINK5 gene in Japanese 57 AD patients and 50 normal healthy controls. We detected nine nonsynonymous variants, including p.K420E; these variants had already been registered in the SNP database. Among them, p.R654H (n=1) was found as a heterozygous mutation in the AD patients, but not in the control. No new mutation was detected. We next compared the data of the AD patients with data from the Human Genetic Variation Database provided by Kyoto University; a significant difference was found in the frequency of the p.S368N genotype distribution. PolyPhen-2 and SIFT, two algorithms for predicting the functional effects of amino acid substitutions, showed significant scores for p.R654H. Therefore, R654H might be a risk factor for epidermal barrier dysfunction in some Japanese AD patients.
Keywords atopic dermatitis SPINK5 LEKTI serine protease inhibitor epidermal barrier dysfunction
Amo Type Original Article
Published Date 2018-06
Publication Title Acta Medica Okayama
Volume volume72
Issue issue3
Publisher Okayama University Medical School
Start Page 275
End Page 282
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2018 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 29926005
JaLCDOI 10.18926/AMO/55860
FullText URL 72_2_185.pdf
Author Morizane, Shin| Sugimoto, Saeko| Motoki, Takayuki| Katayama, Norihisa| Omori, Masako| Iwatsuki, Keiji|
Abstract Psoriasis is a common chronic inflammatory skin disorder that is characterized by scaly, erythematous, sharply demarcated plaques. The treatment for psoriasis has dramatically changed over the last 10 years with the introduction of biologics. However, the risk of cancer induced by biologics for psoriasis has not been fully analyzed, since these agents have such a short history of use. Here we report the case of a 74-year-old woman with psoriasis vulgaris and psoriatic arthritis complicated by breast cancer after systemic treatments including etretinate, cyclosporine, methotrexate, adalimumab, and ustekinumab.
Keywords psoriasis systemic therapy biologics malignancy
Amo Type Case Report
Published Date 2018-04
Publication Title Acta Medica Okayama
Volume volume72
Issue issue2
Publisher Okayama University Medical School
Start Page 185
End Page 187
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2018 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 29674768
FullText URL manuscript.pdf Figure.pdf Table.pdf
Author Umemura, Hiroshi| Yamasaki, Osamu| Kaji, Tatsuya| Hamada, Toshihisa| Otsuka, Masaki| Asagoe, Kenji| Iwatsuki, Keiji|
Keywords angiosarcoma maximum standardized uptake value positron emission tomography positron emission tomography/computed tomography prognostic factor
Note This is an Accepted Manuscript of an article published by Wiley-Blackwell|
Published Date 2017-09
Publication Title Journal of Dermatology
Volume volume44
Issue issue9
Publisher Wiley-Blackwell
Start Page 1046
End Page 1049
ISSN 0385-2407
NCID AA00696658
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
PubMed ID 28370268
DOI 10.1111/1346-8138.13839
Web of Science KeyUT 000409187000022
Related Url isVersionOf https://doi.org/10.1111/1346-8138.13839
FullText URL K0005298_other1.pdf
Author Sakaguchi, Masakiyo| Murata, Hitoshi| Aoyama, Yumi| Hibino, Toshihiko| Widya Putranto, Endy| Winarsa Ruma, I. Made| Inoue, Yusuke| Sakaguchi, Yoshihiko| Yamamoto, Ken-ichi| Kinoshita, Rie| Futami, Junichiro| Kataoka, Ken| Iwatsuki, Keiji| Huh, Nam-ho|
Keywords Cancer Cell Biology Keratinocyte Psoriasis Receptor for Advanced Glycation End Products (RAGE)
Note 学位審査副論文|
Published Date 2014-08
Publication Title Journal of Biological Chemistry
Volume volume289
Issue issue34
Publisher American Society for Biochemistry and Molecular
Start Page 23389
End Page 23402
ISSN 0021-9258
NCID AA00251083
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version publisher
PubMed ID 25002577
DOI 10.1074/jbc.M114.573071
Web of Science KeyUT 000341505000014
Related Url https://doi.org/10.1074/jbc.M114.573071 http://ousar.lib.okayama-u.ac.jp/54281